巻号一覧
52 巻 (2005)
- 4 号 p. 117-
- 3 号 p. 67-
- 1+2 号 p. 1-
52 巻, 4 号
選択された号の論文の7件中1～7を表示しています
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Original Contribution
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ERIKO ODA, YASUHIRO NAKAMURA, MUNEHIKO YAMAMOTO, MASAMICHI KOJIRO2005 年 52 巻 4 号 p. 117-125
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーTubulin is the major constituent protein of microtubules. In mammals, there are seven beta-tubulins and six alpha-tubulins. Each beta-tubulin isotype has a unique tissue distribution. The purpose of this study was to describe the distribution of tubulin beta II in normal and neoplastic human tissues with immunohistochemical techniques. We obtained normal tissues from 33 cases (8 fetuses, 17 neonates, 3 children and 5 adults) and 121 samples of neoplastic tissue from surgical specimens or at autopsy. Immunohistochemical staining for tubulin beta II was performed using a monoclonal antibody, KNY379 developed in our laboratory. Tubulin beta II was detected in various normal tissues, particularly in fetal and neonatal tissues, such as the nervous system, pulmonary alveoli, bronchioles and bronchi, colon, pancreatic ducts and acini, renal convoluted tubuli, skin epidermis, body cavity mesothelial cells, smooth muscle and thymus. In the adult, broad expression was also observed; however, the immunoreactivity was weaker and the extent of its distribution decreased with age. In neoplastic tissues, tubulin beta II immunoreactivity was detected in various nervous system neoplasms and other neoplasms such as pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma. We conclude that our monoclonal antibody, KNY379, may be useful as a marker of nervous system neoplasm, pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.抄録全体を表示PDF形式でダウンロード (4512K) -
TAKASHI SOEJIMA, HIDETAKA MURAKAMI, TAKASHI INOUE, TOMONOSHIN KANAZAWA ...2005 年 52 巻 4 号 p. 127-131
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーTo investigate the direct effect to the cartilage caused by the meniscal repair, we examined patients who underwent an isolated meniscal repair without any other abnormalities by arthroscopic examination. A total of 17 patients were examined by second-look arthroscopy after an average interval of 9 months from the meniscal repair, and have been evaluated the status of the repaired meniscus and of the relative femoral condylar cartilage. Changes in the severity of the cartilage lesion between at the time of meniscal repair and the time of the second-look arthroscopy were considered based on the status of the repaired meniscus. Regardless of the healing status of the repair site, it was possible to prevent degeneration in the cartilage in 9 of the 10 patients who demonstrated no degeneration in the meniscal body. Of the 7 patients who demonstrated degeneration in the meniscal body, progression in cartilage degeneration was noted as 1 grade in 2 patients and 2 grades in another 3 patients. Even in those in which stable fusion of the repair site was achieved, the condition of the inner meniscal body was not necessarily maintained favorably in all cases, indicating that degeneration in the meniscal body was a risk factor for cartilage degeneration. It was concluded that recovery could not be expected even at 9 months after the repair if the lesion had already demonstrated degeneration in the meniscal body at the time of repair.抄録全体を表示PDF形式でダウンロード (668K) -
ITARU UTSUNOMIYA2005 年 52 巻 4 号 p. 133-138
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーRecently, it has been suggested that many of hepatocellular carcinoma (HCC) are of multicentric origin based on the clinicopathologic studies on small HCCs of the early stage and clinical follow-up studies after successful treatments of small HCCs. The author studied the multicentric occurrence of HCC from the point of view of pathomorphology in 168 HCCs less than 3 cm in diameter consecutively resected from 1999 to 2004 and 8 autopsy of liver cirrhosis of micronodular type from 1990 to 2004 at Kurume University Hospital from 1999 to 2004. The association of well-differentiated HCC ranging from 9 mm to 1.2 cm in diameter was found in the non-cancerous tissue of 9 cases (9.5%) among 94 cirrhotic livers. Adenomatous hyperplasia (AH) was found in 7 cases (7.4%). Accordingly, prevalence of synchronous and metachronous multicentric hepatocarcinogenesis was highly suggested in 9.5% and 7.4%, respectively. In 4 (50%) of the 8 autopsy cases of micronodular cirrhosis, however, the coexistence of 2 well-differentiated HCCs around 1.5 cm were found in the different segment. The prevalence of multicentric occurrence in the resected cases is the lowest estimation and true prevalence should be much more higher because HCC cases with multiple nodules are not sent to surgery and the observation is limited in a small area of the subsegmentectomized liver. Indeed, the result of autopsy cases reflects a true prevalence (50%) of synchronous occurrence of HCC.抄録全体を表示PDF形式でダウンロード (1191K) -
DEREK R. SMITH, NING WEI, TATSUYA ISHITAKE, RUI-SHENG WANG2005 年 52 巻 4 号 p. 139-146
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーWe investigated the prevalence and distribution of Musculoskeletal Disorders (MSD) among Chinese medical students, by means of a questionnaire survey. A total of 207 questionnaires were successfully returned, giving a high response rate of 92.4%. The MSD period-prevalence at any body site was 67.6% in the previous year and 46.9% in the previous week. Almost one-third of them (31.9%), reported an ongoing MSD. By individual body site, the most commonly affected region was the lower back (40.1% in the last year), followed by the neck (33.8%) and shoulders (21.7%). The 7 day period-prevalence also followed a similar descending pattern, being reported by 20.8% at the lower back and 12.1% at both the neck and knees. MSD affected the daily life of students for an average period of 53.8 days, with an average of 6.6 sick days taken from school. Students reporting high mental pressure were 2.9 times more likely to suffer low back pain in the previous 12 months (OR 2.9, 95%CI 1.4-5.9, P=0.0030). Overall, our study suggests that Chinese medical students are at reasonable MSD risk, although it is probably lower than for working physicians. Further investigations are now recommended to elucidate the MSD mechanisms and contributory factors among medical students in China, as elsewhere. A longitudinal study of MSD among a complete group of medical students would be very useful in this regard.抄録全体を表示PDF形式でダウンロード (1029K) -
DEREK R. SMITH, PETER A. LEGGAT2005 年 52 巻 4 号 p. 147-151
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーThe purpose of this study was to investigate the epidemiology of tobacco smoking among dentists in Queensland, Australia. We utilized an anonymous, self-reporting questionnaire which was posted to 400 dentists during 2004. The overall response rate was 72.1%, among whom the prevalence of current smoking was estimated to be 3.9% (95%CI: 2.2-6.9), with a further 11.0% being ex-smokers (95%CI: 7.9-15.2). Smoking rates varied by age, with 6.1% of dentists aged younger than 30 years who were smokers. The lowest smoking prevalence was seen among dentists aged between 30 and 40 years (1.4%), and the highest among those aged over 60 years (7.1%). Regarding weekly work hours, the highest smoking prevalence was seen among dentists who worked between 25 and 35 hrs per week (6.8%). Ex-smokers were more likely to work less than 25 hrs per week (21.7%). Smoking rates also varied by career length, with the lowest prevalence among dentists who had worked 10 to 20 years (1.3%) and the highest rate among those who had worked over 40 years (6.7%). A similar trend was revealed for ex-smokers, with prevalence rates of 1.7% and 33.3%, respectively. Overall, our study suggests that the prevalence of smoking is rather low among Queensland dentists. As the distribution of smoking was not uniform however, future preventive measures will need to consider the individual situation of dentists who smoke, particularly those in the older age groups.抄録全体を表示PDF形式でダウンロード (551K) -
YASUNORI MISHIMA, HIDEKI HARADA, KAZUHIDE SUGIYAMA, YOSHIKADO MIYAGAWA ...2005 年 52 巻 4 号 p. 153-160
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーWe have examined ischemic tolerance induced by electroconvulsive shock before exposure to forebrain ischemia. Subjects were 40 rats, which were randomly allocated to control, single ECS (sECS), repeated ECS (rECS) or sham group. sECS group and rECS group received ECS only once 2 days before the subsequent 8-min forebrain ischemia and once a day for 9 consecutive days until 2 days before the exposure to ischemia, respectively. Forebrain ischemia was produced by modified bilateral carotid artery occlusion technique. Control group underwent brain ischemia without ECS pretreatment. Sham group received ECS without following exposure to ischemia. Pyramidal cell injury of the hippocampal CA1 sector was microscopically examined on the 7th day after the ischemic exposure or the sham operation. Damage of the pyramidal cells was assessed by the injury ratio, which was ratio of non-viable pyramidal cells to the whole pyramidal cells. The injury ratios of CA1 pyramidal cells in sECS, rECS and control groups were 30.5±10.8 (n=10), 42.3±18.4% (n=10) and 90.4±2.9% (n=9), respectively. The injury ratios in sECS and rECS groups were lower than the ratio in control group (p<0.01), while the ratios of sECS and rECS groups were not different. The pyramidal cells in sham group were intact. Our results indicate that both preconditionings of sECS and rECS have a potency to induce delayed tolerance against temporary forebrain ischemia, though the potency was not different between sECS and rECS. Electroconvulsive shock may be added to the list of preconditioning stimuli to protect brain against ischemic neuronal damage.抄録全体を表示PDF形式でダウンロード (1323K)
Case Report
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HIDEYA SUGA, OSAMU TSURUTA, YOSHINOBU OKABE, FUMIHIKO SAITOH, TETSUROU ...2005 年 52 巻 4 号 p. 161-164
発行日: 2005年
公開日: 2006/08/04
ジャーナル フリーA 57-year-old man with a 3-year history of chronic pancreatitis was admitted to our hospital with upper abdominal pain. Based on examination findings, the patient was diagnosed as having pseudocysts in the pancreatic body and the mediastinum that were associated with acute aggravation of chronic pancreatitis. Because of the patient refused an operation, he was submitted to conservative management including intramuscular injection with somatostatin analogue of 100 μg/day. On the 14th day of the treatment, pleural effusion and pseudocyst in the pancreatic head were additionally diagnosed based on the findings of computed tomography, magnetic resonance imaging and other examinations, and the dose of somatostatin analogue was increased to 200 μg/day. As a result, on the 28th day of the treatment, pancreatitis was inactivated, and the pseudocysts in the mediastinum and the pancreas disappeared. The patient has been followed up for 15 months, and there has been no recurrence.抄録全体を表示PDF形式でダウンロード (837K)
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