Quoting the theories of Hisayuki Omodaka, Karl Jaspers, Schin-ichi Hisamatsu, Henri Bergson, Andre Breton, the author explains in this article the importance and the necessity of Mediophilosopy putting its basis on oriental studies, especially traditional Chinese Medicine.
Anti-tumor effect of extracts (Bamfolin) from bamboo grass on patient diagnosed cancer was at first found clinically. At the fundamental studies on this, many investigators have been presented evidence which suggests that antitumor effect might due to indirect effect of the polysaccharide against cancer through the host. We, recently, found that the extracts contained the other components affected the tumor cells directly. Crude Bamfolin was fractionated in the order of molecular weight by dialysis against distilled water and gelfiltration on Sephadex G-25 and G-50. Each fractions were tested by means of CAP-method, contact test and experimental therapeutic test using Ehrlich carcinoma and Sarcoma-180. From these tests, we found that the sugar fraction (mol. wt. >10, 000) showed the inhibition of the growth of Ehrlich ascites carcinoma by i.p. injection in mice and the sugar fraction (mol. wt. <10, 000) had only slight anti-tumor effect. The first injection of the test samples was started at 6 hr after tumor implantation and the following injections were done twice a day for three days from next day. Then, in 1mg/mouse×7 doses, the sugar fraction (mol. wt. >10, 000) saved all mice. But the sugar fraction (mol. wt. <10, 000) saved only about 20-40 per cent of mice. From these data, it is suggested that the action may be directly cytocidal. The details of differences between this effective sugar fraction and former polysaccharide, which is so-called host mediator, are under investigation.
This report deals with 3 autopsy cases of 4 years girl, 18 years male and 14 years boy, succumbed to alveolar rhabdomyosarcoma, originating in the nasal cavity, paranasal ninus and right forearm respectively. On section, wide spread metastasis were found in the lungs, pancreas, liver, spleen, kidneys, heart, adrenal glands, ovaries, fronto-parietal region, ribbs, vertebrae and lymphnodes. Biopsy specimens were removed repeatedly from original and metastatic tumors. Original diagnosis were nonepithelial malignant tumor (case 1), epithelial malignant tumor (case 2) and small cell sarcoma (case 3) respectively. Although the diagnosis was done in the case 2 and 3 histologically during their lives, the case 1 was diagnosed with fifficulty after the autopsy. Histologically characteristic pseudo-alveolar pattern was predominant in all cases. In the cases 2 and 3, the typical longitudinal and cross striations were obviously demonstrated in racket and tadpole cells.
Recently, for the benefit of nonblaze and nonexplosion, the inhalations anesthetics which have chemical constructions of C, Cl and F have been used generally. But, it is reported that by using these anesthetics in the room which is not well ventilated and when there are blazes, the mucous membrances of eyes and nose are irritated with light headaches. So, it may be assumed that the cause of these symptoms might occur from the poisonous gases which are derived by the decomposition of the anesthetic gases coming in contact with the blaze in the room. For the investigation of the above question, the authors checked the outbreak of the poisonous gases from the inhalations anesthetic gas using Fluothane ([chemical formula] : Takeda Pharmacy Company). Phosgene 0.002-0.02ppm. and hydrogen-chloride gas 300ug. per 10ml. of Fluothane vapor which passed through high temperature were recognized. The authors also felt the irritation of the noses and eyes, which may come from the hydrogen-chloride gas. Two young rats were laid in the glass bottle which were filled by Fluothane vapor according to the above mentioned condition for histological examination, but no reactions showed in their lungs, tracheas and bronchi by phosgene, chloride and hydrogenchloride gases.
Renal biopsy was made in a patient with SLE, 17 years old, when the patient showed the symptoms of acute exacerbation (fever, erythema, psychosis, marked proteinuria, elevation of ANF titers, and anti-DNA antibody). The immunofluorescence staining revealed diffuse fine granular deposits of γG- and beta-1-C globulin in the glomerular basement membrane as well as in the muscle layers of arterioles and interlobular arteries. This immunofluorescence finding seems to be very important for the elucidation of renal involvement of SLE.
Four cases of the intermediate coronary syndrome were described, all of which were difficult to differentiate from the myocardial infarction. In this syndrome, the cases showing a series of changes have been seen between the angina pectoris and the myocardial infarction. Although the intermediate coronary syndrome includes all of these cases together at the present, some of them are intimately related to the myocardial infarction while the others are close to the classical form of the angina pectoris. Post-mortem examination has revealed high incidence of the myocardial infarction in the patients who had been diagnosed as intermediate coronay syndrome during their lives. Considering from this fact, the author emphasizes that clinician should be prudent not to abuse the term of an intermidate type merely in virtue of its convenience, since the myocardial infarction or undifferential case is not belonging to this syndrome.
In the summer of 1970, an outbeak of Hand, Foot, and Mouth Disease was observed in Tokyo. The 35 children (17 males and 18 females) were ranged in age from 7 months to 7 years. The clinical aspects of this disease have been outlined and compared with similar outbreaks reported since 1958.
Nonepithelial tumors of the urinary bladder are rare and among these benign tumors are far more rare. A case of leiomyoma of the urinary bladder is reported. A male patient, aged 59 years, was admitted to our hospital with complaints of dysuria and marked hematuria. Cystoscopic examination revealed a ball shaped tumor, pigeon egg in size, with normal mucosal covering, located on the right side of the bladder neck. Urethrocystography revealed a filling defect by the tumor. This was diagnosed preoperatively as a benign mesenchymal tumor, and was removed by cystotomy. The tumor was yellowgreyish macroscopically, weighed 20gm., measured 3.8×3.5×3.0cm, and was diagnosed pathohistologically as a leiomyoma. This is the 36th reported case in Japanese literature.