JOURNAL OF THE KYORIN MEDICAL SOCIETY
Online ISSN : 1349-886X
Print ISSN : 0368-5829
ISSN-L : 0368-5829
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Review-Article
  • Aki Obara
    2021 Volume 52 Issue 3 Pages 115-120
    Published: September 29, 2021
    Released: September 29, 2021
    JOURNAL FREE ACCESS

    Equol is formed during the biotransformation of the naturally occurring isoflavone daidzein by intestinal bacteria. It has a stronger estrogenic effect than isoflavone. Therefore, equol is expected to affect the prevention of several hormone-dependent diseases such as prostate cancer, breast cancer, and menopause symptoms. However, the exact structure of the equol conjugates, for example, the position of conjugation sites, that circulate in vivo has not been determined. We synthesized equol metabolites and identified equol-G-’S in human plasma using LC-MS/MS by standard addition method. This paper describes equol metabolites analysis of the main metabolite in human plasma, and considers associated issues and prospects, with the focus on equol therapeutic potential.

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