We observed and discussed the effects of Free Electron Laser (FEL) irradiation to cholesterol accumulated in the regions of arteriosclerosis in the human carotid artery, by an Infrared micro spectroscopy (FT-IR). As a result of this study, we found that we could selectively remove cholesterol only without effects to normal parts of the human body, in irradiating 5.75 μm-FEL that come from a ester bond of cholesterol ester, under the condition that average power is 5 mW, power density is ∼16 W/cm
2 and irradiation time is 30∼180 sec.
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