巻号一覧
35 巻, 8 号
選択された号の論文の9件中1～9を表示しています
- |<
- <
- 1
- >
- >|
-
會沢 勝夫, 中村 厚2007 年 35 巻 8 号 p. 481-485
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーTalaporfin is a photosensitizer of the molecular weight 799.73. We can check the lesion by observing fluorescence using the endoscopes image and fluorescence spectrum equipment. We introduce angioscope fluorescent image analysis equipment into an abdominal aorta with a hyperlipidemia rabbit, and are accumulated Talaporfin on the inner arteriosclerosis was observed. The arteriosclerosis part of the coronary arteries and its tip arteriole excited Talaporfin by 405 nm, and has observed it as a fluorescent image from the surface outside the heart. By the infrared spectrum, we observed the process to which arteriosclerosis is expanded. As a result, absorption peaks of arteriosclerosis at the ester and fatty acid increased and the ratio of the peak was 0.30. The (C=O) absorption peak of the cholesterol ester of arteriosclerosis was decreasing by the photodynamic therapy. The photodynamic therapy of the arteriosclerosis enabled target to observe spectra of ester. It seems that this observation can advance one big step towards the 21st century抄録全体を表示PDF形式でダウンロード (5290K) -
平野 達2007 年 35 巻 8 号 p. 486-492
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーPDT is based on the generation of singlet oxygen (1O2) in a photochemical reaction among a tumor-accumulated photosensitizer, irradiation light, and oxygen in a tumor, and the detection of 1O2 is very important for understanding the mechanism of PDT. We used a near-infrared detection system to detect a 1270nm emission that was derived from the 1O2. Utilizing this system, we detected the generation of 1O2 from Photofrin dissolved in water or injected in a HeLa tumor-bearing mouse. We showed the irradiation power dependence of the generation of 1O2 in 5-ALA-mediated PDT with 9L cells and 9L tumor-bearing rats. High-power irradiation reduced the generation of 1O2 more than that with low power, and an MTT assay revealed that more 9L cells were killed by low-powered irradiation. In tumors, low-powered irradiation resulted in efficient tumor necrosis. Generations of 1O2 in ICG and TiO2 irradiation are also described.抄録全体を表示PDF形式でダウンロード (14001K) -
金田 明, 峰久 次郎2007 年 35 巻 8 号 p. 493-497
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーPhotodynamic therapy (PDT) is a treatment applied by a laser system in combination with a photosensitive drug (photosensitizer) that is excited by laser light. Accumulation of the photosensitizer at the disease site and local excitation by laser irradiation make it possible to selectively treat the diseased region, preserving the functionality and appearance of the treated area. Photodynamic Diagnosis (PDD) enables the identification of a specific disease site through the capturing of fluorescence generated by the photosensitizer. It is expected PDD will prove useful in identifying the disease site for Glioblastoma, amalignant brain tumor for which clear boundaries cannot be easily detected.抄録全体を表示PDF形式でダウンロード (16407K) -
PDT反応の動的挙動と細胞内薬剤動態川内 聡子, 佐藤 俊一, 菊地 眞2007 年 35 巻 8 号 p. 498-502
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーPhotodynamic therapy with pulsed light excitation has interesting characteristics; however, its photosensitization mechanism has not been fully elucidated. We investigated the correlation between oxygen consumption and photobleaching during photodynamic treatment with nanosecond pulsed light excitation and a secondgeneration, lysosomal sensitizer in vitro, and obtained “fluorescence-oxygen diagram” at different pulse frequencies. The diagrams showed that initial oxygen-dependent photobleaching was switched to an oxygenindependent photobleaching, which was re-switched to an oxygen-dependent reaction at the higher frequencies of 10 and 30 Hz; such changes were not observed at 5 Hz. The complex behaviors revealed by the diagrams at 10 and 30 Hz were shown to be associated with the intracellular kinetics of the sensitizer, i.e., initial localization in lysosomes and redistributionto the cytosol during the treatment. The pulse frequencydependent intracellular kinetics of the sensitizer also explained the higher cytotoxicity at 5 Hz than at 10 and 30 Hz.抄録全体を表示PDF形式でダウンロード (8900K) -
澤田 修, 大路 正人2007 年 35 巻 8 号 p. 503-508
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーAge-related macular degeneration (AMD) is the leading cause of legal blindness in developed countries. No effective treatments had existed until Photodynamic therapy using Verteporfin was approved following clinical trials. Treatment of Age-related Macular Degeneration With Photodynamic therapy investigation (TAP investigation) was carried out in United States and Europe and the Japanese Age-related Macular Degeneration Trial (JAT) was in Japan. TAP investigation showed a reduction of moderate and severe vision loss compared with placebo treatment although mean visual acuity decreased even in the PDT group. On the other hands, mean visual acuity was maintained or slightly improved in JAT study. More recently, anti-VEGF drugs, including antibody or aptamer have been shown to be effective for AMD and achieved improvement of mean visual acuity. A combination therapy of PDT and anti-VEGF drugs might achieve further improvement of vision and could become the first choice for AMD treatments抄録全体を表示PDF形式でダウンロード (23103K) -
臼田 実男, 一ノ瀬 修二, 石角 太一郎, 平田 剛史, 井上 達哉, 大谷 圭志, 今井 健太郎, 久保田 光博, 角田 佳彦, 筒井 ...2007 年 35 巻 8 号 p. 509-513
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーPhotodynamic therapy (PDT), one of the treatment modalities for cancer, uses a photosensitizer and laser irradiation to induce the production of reactive oxygen species in cancers cells. In Japan, the United States, and many other countries, PDT is widely used as a treatment option for solid cancers. In the therapeutic guidelines for lung cancer established in 2002 by the Japanese Ministry of Health, Labor and Welfare based on the principle of evidence-based medicine, PDT is the recommended treatment modality for centrally located early stage lung cancer. It has been reported that PDT rapidly induce apoptosis, inflammatory reaction, tumor specific and/or nonspecific immune reaction and damages the microvasculature of the tumor bed. The mechanism of action of PDT is unique and is not well known. In this paper, we discuss the mechanism of the induction of apoptosis or necrosis following PDT.抄録全体を表示PDF形式でダウンロード (2964K) -
橋本 直哉, 加藤 天美, 泉本 修一, 吉峰 俊樹2007 年 35 巻 8 号 p. 514-518
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーThe authors described the recent advancement of photodynamic diagnosis (PDD) and therapy (PDT) in neurosurgical field. Intra-operative PDD using 5-aminolevlulinic acid (5-ALA) and violet blue excitation light is now recognized as one of the multidisciplinary treatment modalities for malignant gliomas. The results of PDD in a series of 38 patients who treated in Osaka University Hospital between 2004 and 2006 were presented thoroughly, as well as the review of clinical trial studies in the world.Although the methodology of photodynamic therapy (PDT) for malignant brain tumors is not establishedyet, various PDT clinical trials showed promising results of PDT, as well as the needs for some improvements on photosensitizers and development of simpler and more efficient light delivery systems for neurosurgery.抄録全体を表示PDF形式でダウンロード (5236K) -
坂本 隆, 石井 克典, 櫛引 俊宏, 粟津 邦男2007 年 35 巻 8 号 p. 519-522
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーPhotodynamic Diagnoses (PDD) are commonly applied in clinical and basic research areas. A conventional PDD with the maximal absorption wavelength of a photo sensitizer accumulated in the tumor tissue reveals its location. In this study, we evaluated the tissue transmittance of the lasers of two different wavelengths, 405 and 664 nm. These are the maximal absorption wavelengths of Talaporfin Sodium and appeared at different penetration depths in the tumor tissue. When these two wavelength lasers were irradiated to the tissue, different fluorescent intensities were obtained. From these different intensities and the different penetration depths of the lasers, the depth of the tumor's location is clarified.抄録全体を表示PDF形式でダウンロード (4723K) -
伊藤 基巳紀, 小田 勝志, 川田 通広, 木村 正廣2007 年 35 巻 8 号 p. 523-526
発行日: 2007/08/15
公開日: 2014/03/26
ジャーナル フリーWe have developed a compact inexpensive system for observing lymphatic vessels through the skin tissue. This method utilizes the high transmittance of near-infrared light through skin tissue and water; it is free from the dangers of radiation. Indocyanine green is used as the contrast dye, and it absorbs and emits near-infrared radiation. A few hours after injecting the dye solution subcutaneously, the lymphatic vessels are clearly observed using an infrared camera.抄録全体を表示PDF形式でダウンロード (5058K)
- |<
- <
- 1
- >
- >|