Journal of the Mass Spectrometry Society of Japan

報文

磁場型高性能質量分析計のイオン光学

松田久

1995 年 43 巻 4 号 p. 165-176
発行日: 1995年
公開日: 2007/07/20

DOIhttps://doi.org/10.5702/massspec.43.165

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Ion optical investigation on high performance mass spectrometer is described. The field arrangement QQQOHQCQ (Q: Quadrupole, O: Octapole, H: Homogeneous magnetic sector, C: Cylindrical electric sector) is suitable for the design of mass spectrometers with ultra high resolution (AF=926,000) and with very large mass dispersion (C/AM=4). A zoom mass spectrometer is proposed by adjusting only the applied electric potentials to three quadrupoles without changing geometrical configuration. The image magnification can be changed from 0.046 to 0.187 continuously keeping small image aberrations. Very small size and high performance mass spectrometer is available by using double sector magnet. The correction of image aberrations by hexapole is discussed.

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Collision-Induced Dissociation of the Alkali-Metal Adduct Ions [M + c]⁺ and [M + 2c - H]⁺ (c=Na and K): Trolox and a Phospholipid

Mitsuo TAKAYAMA

1995 年 43 巻 4 号 p. 177-188
発行日: 1995年
公開日: 2007/07/20

DOIhttps://doi.org/10.5702/massspec.43.177

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Collision-induced dissociation (CID) spectra of sodium adduct [M + Na]⁺ and [M + 2Na - H]⁺ ions of Trolox and a phospholipid L-α-phosphatidyl-N-monomethylethanolamine, produced under fastatom bombardment conditions, have been compared with the corresponding CID spectra of potassium adduct [M + K]⁺ and [M + 2K - H]⁺ ions, in order to examine the influence of cation size on the CID patterns. While the CID spectra of mono-metal adduct ions [M + c]⁺ (c=Na and K) agreed with each other in pattern, the CID spectrum of dipotassium-adduct [M + 2K - H]⁺ ion of the phospholipid showed a definite pattern of chargeremote fragmentation and it was different from that of di-sodium adduct [M + 2Na - H]⁺ ion in fragment intensity. The CID spectra of di-metal adduct ions [M + 2c - H]⁺ (c=Na and K) gave a number of di-metal containing fragments. On the basis of the results obtained, the structures of alkali metal adduct [M + c]⁺ and [M + 2c - H]⁺ ions have been discussed.

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Rapid Profiling of Urinary Organic Acids Due to Inherited Metabolic Disorders by Liquid Ionization Mass Spectrometry

Yukio YOKOYAMA, Naoyuki OHMORI, Masahiko TSUCHIYA

1995 年 43 巻 4 号 p. 189-201
発行日: 1995年
公開日: 2007/07/20

DOIhttps://doi.org/10.5702/massspec.43.189

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An application of liquid ionization (LI) mass spectrometry to the profiling of urinary organic acids due to several inherited metabolic disorders is described. A solid-phase extraction technique using DOWEX 50W-X8 was developed to remove urea and cationic species from urine matrix. This preliminary sample treatment was quite effective to detect urinary organic acids for LI mass spectrometry. LI mass spectra for dicarboxylic acidurias clearly exhibited the peaks of adipic (m/z 147), suberic (m/z 175), and sebacic (m/z 203) acids due to the disease. Those for lactic and methylmalonic acidurias exhibited the intense peaks of lactic (m/z 91) and methylmalonic (m/z 119) acids, respectively. For phenylketonuria, the peaks corresponding to phenylacetic (m/z 137) and phenyllactic (m/z 167) acids, which are diagnostic metabolites, were intensely observed. All mass spectra for the urine samples of the patients were quite indicative of the individual metabolic diseases. Furthermore, a principal component analysis was examined to classify the spectral patterns using 40 peaks selected. The mass spectra of patients with five kinds of metabolic diseases were differentiated from those of healthy newborns by the principal component plots.

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