巻号一覧
58 巻, 1 号
選択された号の論文の4件中1～4を表示しています
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一般論文
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Minoru UCHIYAMA, Minoru OGUCHI, Naotoshi YAMAMURA, Hiroko KODA, Thomas ...2010 年 58 巻 1 号 p. 1-11
発行日: 2010/02/01
公開日: 2010/02/15
ジャーナル フリーThe in vitro metabolism of rosiglitazone (RGZ) was studied in freshly isolated human, rat, and monkey hepatocytes. The metabolites of [14C]RGZ produced by incubation with hepatocytes were detected by radioactivity detection high-performance liquid chromatography. Seven metabolites (M1-M7) of RGZ were detected in human hepatocytes. The structures of the metabolites were elucidated by liquid chromatography/tandem mass spectrometry using electrospray ionization. The structural analysis demonstrated that M1, M2, and M4 were novel metabolites of RGZ. M1 was identified as a 2,4-thiazolidinedione (TZD) ring-opened N-glucuronide. M2 was identified as a TZD ring N-glucuronide. M4 was proposed to be a TZD ring-opened methylmercapto amide. Similarly, these metabolites were also detected in rat and monkey hepatocytes. To our knowledge, this is the first report on N-glucuronidation of TZD rings. Based on the structures of the metabolites, we propose the following novel in vitro metabolic pathways for RGZ: 1) N-glucuronidation of the TZD ring of RGZ to form M2 followed by hydrolysis to the TZD ring-opened N-glucuronide M1; and 2) methylation of the mercapto group of the TZD ring-opened mercapto amide to form M4.抄録全体を表示PDF形式でダウンロード (520K)
解説
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第4回 光イオン化法の特徴田中 健一郎, 小谷野 猪之助2010 年 58 巻 1 号 p. 13-16
発行日: 2010/02/01
公開日: 2010/02/15
ジャーナル フリーFundamental aspects of molecular photoionization are described in comparison with electron ionization, emphasizing the difference in the threshold behavior.抄録全体を表示PDF形式でダウンロード (532K)
総説
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第5回 内殻励起反応和田 真一, 田中 健一郎2010 年 58 巻 1 号 p. 17-27
発行日: 2010/02/01
公開日: 2010/02/15
ジャーナル フリーCore electron excitation possesses an attractive potential of inducing selective chemical bond breaking. Compared to valence excitation, core excitation takes place within a small area because of its spatial localization and atomic selectivity. Therefore, a specific atom in a molecule can be excited selectively. The core-excited state is quite unstable with an extremely high energy, so consecutive decay processes—Auger decay and ionic dissociation—can occur in the vicinity of the excited atom. From this concept, site-selective ionic fragmentation has been widely and successfully investigated in various core-excited molecular systems. This paper briefly describes the characteristics of core excitation and experimental methods, and then reviews representative recent studies about site-selective chemical bond breaking induced by core excitation.抄録全体を表示PDF形式でダウンロード (1682K)
Letter from the Editor
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～“MS”, simple is correct.～吉野 健一2010 年 58 巻 1 号 p. 29-34
発行日: 2010/02/01
公開日: 2010/02/15
ジャーナル フリー“MS” is an abbreviation for “mass spectrometry.” “Bunseki” and “Kaiseki” in Japanese are equivalent for “analysis” in English. A Japanese word “Sokutei” is for the English word “measurement.” Thus, the Japanese words “MS-Bunseki,” “MS-Kaiseki” and “MS-Sokutei” are redundant expressions.抄録全体を表示PDF形式でダウンロード (699K)
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