Mass Spectrometry
Online ISSN : 2186-5116
Print ISSN : 2187-137X
ISSN-L : 2186-5116
Volume 6 , Issue 3
Special Issue: International BMS Symposium 2016
Showing 1-8 articles out of 8 articles from the selected issue
  • Lee Chuin Chen, Kentaro Yoshimura, Satoshi Ninomiya, Sen Takeda, Kenzo ...
    2017 Volume 6 Issue 3 Pages S0070
    Published: August 25, 2017
    Released: August 23, 2017

    In this paper, we briefly review the remote mass spectrometric techniques that are viable to perform “endoscopic mass spectrometry,” i.e., in-situ and in-vivo MS analysis inside the cavity of human or animal body. We also report our experience with a moving string sampling probe for the remote sample collection and the transportation of adhered sample to an ion source near the mass spectrometer. With a miniaturization of the probe, the method described here has the potential to be fit directly into a medical endoscope.

  • Akira Motoyama, Keishi Kihara
    2017 Volume 6 Issue 3 Pages S0071
    Published: September 26, 2017
    Released: September 22, 2017

    To provide safe and effective products to customers in the cosmetic industry, mass spectrometry (MS) is an indispensable analytical tool. In addition to its outstanding sensitivity and specificity, the method is applicable to a wide variety of compounds, which makes it irreplaceable for the development of cosmetics, which requires the analysis of complex systems. Because most cosmetic products are applied directly to the skin and function as they are designed, monitoring the molecular compositions of endogenous or exogenous compounds in or on the skin is crucial to ensure the safety and efficacy of a cosmetic product. Recent advancements in MS and ionization techniques, such as MS imaging and ambient ionization, now provide access to richer and deeper molecular information with less time and effort. This brief review discusses advanced ionization techniques that are currently used in the field of cosmetic science using two examples, namely, the use of desorption electrospray ionization and zero-volt paperspray ionization to detect trace molecules in or on human skin.

  • Yin-Hung Lai, Yi-Sheng Wang
    2017 Volume 6 Issue 3 Pages S0072
    Published: September 19, 2017
    Released: September 22, 2017

    Although matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is one of the most widely used soft ionization methods for biomolecules, the lack of detailed understanding of ionization mechanisms restricts its application in the analysis of carbohydrates. Structural identification of carbohydrates achieved by MALDI mass spectrometry helps us to gain insights into biological functions and pathogenesis of disease. In this review, we highlight mechanistic details of MALDI, including both ionization and desorption. Strategies to improve the ion yield of carbohydrates are also reviewed. Furthermore, commonly used fragmentation methods to identify the structure are discussed.

  • Toshiki Sugai
    2017 Volume 6 Issue 3 Pages S0074
    Published: December 22, 2017
    Released: December 26, 2017

    The relationship between mass and charge has been a crucial topic in mass spectrometry (MS) because the mass itself is typically evaluated based on the m/z ratio. Despite the fact that this measurement is indirect, a precise mass can be obtained from the m/z value with a high m/z resolution up to 105 for samples in the low mass and low charge region under 10,000 Da and 20 e, respectively. However, the target of MS has recently been expanded to the very heavy region of Mega or Giga Da, which includes large particles and biocomplexes, with very large and widely distributed charge from kilo to Mega range. In this region, it is necessary to evaluate charge and mass simultaneously. Recent studies for simultaneous mass and charge observation and related phenomena are discussed in this review.

Original Article