Mass Spectrometry
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Special Issue: International BMS Symposium 2016
Showing 1-7 articles out of 7 articles from the selected issue
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Preface
Review
  • Lee Chuin Chen, Kentaro Yoshimura, Satoshi Ninomiya, Sen Takeda, Kenzo ...
    Volume 6 (2017) Issue 3 Pages S0070
    Released: August 23, 2017
    JOURNALS FREE ACCESS FULL-TEXT HTML

    In this paper, we briefly review the remote mass spectrometric techniques that are viable to perform “endoscopic mass spectrometry,” i.e., in-situ and in-vivo MS analysis inside the cavity of human or animal body. We also report our experience with a moving string sampling probe for the remote sample collection and the transportation of adhered sample to an ion source near the mass spectrometer. With a miniaturization of the probe, the method described here has the potential to be fit directly into a medical endoscope.

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  • Akira Motoyama, Keishi Kihara
    Volume 6 (2017) Issue 3 Pages S0071
    Released: September 22, 2017
    JOURNALS FREE ACCESS FULL-TEXT HTML

    To provide safe and effective products to customers in the cosmetic industry, mass spectrometry (MS) is an indispensable analytical tool. In addition to its outstanding sensitivity and specificity, the method is applicable to a wide variety of compounds, which makes it irreplaceable for the development of cosmetics, which requires the analysis of complex systems. Because most cosmetic products are applied directly to the skin and function as they are designed, monitoring the molecular compositions of endogenous or exogenous compounds in or on the skin is crucial to ensure the safety and efficacy of a cosmetic product. Recent advancements in MS and ionization techniques, such as MS imaging and ambient ionization, now provide access to richer and deeper molecular information with less time and effort. This brief review discusses advanced ionization techniques that are currently used in the field of cosmetic science using two examples, namely, the use of desorption electrospray ionization and zero-volt paperspray ionization to detect trace molecules in or on human skin.

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  • Yin-Hung Lai, Yi-Sheng Wang
    Volume 6 (2017) Issue 3 Pages S0072
    Released: September 22, 2017
    JOURNALS FREE ACCESS FULL-TEXT HTML

    Although matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is one of the most widely used soft ionization methods for biomolecules, the lack of detailed understanding of ionization mechanisms restricts its application in the analysis of carbohydrates. Structural identification of carbohydrates achieved by MALDI mass spectrometry helps us to gain insights into biological functions and pathogenesis of disease. In this review, we highlight mechanistic details of MALDI, including both ionization and desorption. Strategies to improve the ion yield of carbohydrates are also reviewed. Furthermore, commonly used fragmentation methods to identify the structure are discussed.

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