巻号一覧
13 巻 (1988)
- 6 号 p. 308-
- 5 号 p. 248-
- 4 号 p. 188-
- 3 号 p. 124-
- 2 号 p. 62-
- 1 号 p. 2-
13 巻, 6 号
選択された号の論文の5件中1～5を表示しています
- |<
- <
- 1
- >
- >|
-
乾 賢一1988 年 13 巻 6 号 p. 308-320
発行日: 1988/11/01
公開日: 2011/03/04
ジャーナル フリーThis article deals with the analysis of drug transport systems in the plasma membranes of the intestinal and renal epithelial cells. Aminocephalosporins such as cephradine and cephalexin, possessing an α-amino group and a carboxyl group, can be transported via common carrier system with dipeptides in the intestinal and renal brush border membranes, and that this process is driven by an inward H+ gradient (H+ cotransport system). The tubular secretion involves transport across basolateral membranes, and accumulation in the epithelial cells followed by efflux from the cells across brush border membranes into the urine. Tetraethylammonium (TEA), a prototype cation, is transported across basolateral membranes via carrier-mediated system, which is stimulated by an inside-negative membrane potential. TEA transport across brush border membranes is driven by an H+ gradient via electroneutral H+/ TEA antiport system. In contrast, p-aminohippurate is transported by an anion exchange mechanism in basolateral membranes. Thus, the vesicle studies have provided a great deal of information about the coupled transport of drugs in the intestine and renal tubule.抄録全体を表示PDF形式でダウンロード (1549K) -
大谷 敏郎, 渡辺 敦夫, 木村 尚史1988 年 13 巻 6 号 p. 321-334
発行日: 1988/11/01
公開日: 2011/03/04
ジャーナル フリーDynamic membrane can be formed by filtering a feed solution containing a membrane forming material through a porous support. The principle of this membrane was first reported in 1966 with hydrous Th (IV) as a membrane forming additive. Since then, in making of RO or UF membranes, most of the research and development studies on dynamic membranes has been concentrated on searching membrane forming additives and on determining optimum formation processes. We classify dynamic membranes into two types, a pre-coat type and a self-rejecting type. The pre-coat type is a normal dynamic membrane for RO or UF membrane previously descried. In the self-rejecting type, the depositl ayer, composed of macromolecular solute such as synthetic polyelectrolyts or protein, has a ultra-filtration, ability for the solute. The development and current research of these dynamic membranes is to be reviewed.
Although many studies of the dynamic membranes were conducted with ceramics, stainless steel and carbon tubes as porous supports, pore sizes of supports were widely distributed. But, along with the advancement in materials development, the pore size and its distribution have become small and narrow, respectively. Today, the porous support, especially made of ceramics and glass, can be used as inorganic MF or UF membrane. These inorganic membranes will also be reviewed briefly.抄録全体を表示PDF形式でダウンロード (1947K) -
中嶋 直敏1988 年 13 巻 6 号 p. 335-346
発行日: 1988/11/01
公開日: 2011/03/04
ジャーナル フリーOur approaches to the developments of bilayer transduction devices are described. First approach is the combination of host-guest chemistry and synthetic bilayer membrane chemistry. Mixed bilayer membranes of chiral aromatic amphiphiples and crown ethers can descriminate ionic signals with high selectively throgh transduction to spectroscopic information (Spectrochemical transducer).
Secondly, excitation phenomena of synthetic bilayers are described. Electric measurements were made for Millipore membranes impregnated with polyion complexes of bilayer membranes. Self-osillation of the membrane electric potential was observed at temperatures near phase transitions. Here, bilayers act as electrochemical transducer from d. c. informations to a. c. informations. Finally, a potential of molecular bilayer assemblies as a transducer of chemical information is further emphasized with a. c. impedance characteristics of bilayer-modified electrodes.抄録全体を表示PDF形式でダウンロード (1179K) -
Masakazu Yoshikawa, Masahiro Kishida, Masataka Tanigaki, Wataru Eguchi1988 年 13 巻 6 号 p. 347-349
発行日: 1988/11/01
公開日: 2011/03/04
ジャーナル フリーPDF形式でダウンロード (269K) -
Toshinori Tsuru, Fumie Yamaguchi, Shin-ichi Nakao, Shoji Kimura1988 年 13 巻 6 号 p. 350-358
発行日: 1988/11/01
公開日: 2011/03/04
ジャーナル フリーSeparation of protein mixtures and amino acid mixtures by electrically enhanced ultrafiltration (EUF) and microfiltration (EMF) was studied. EUF and EMF are new membrane separation processes combined with electrophoresis.
Membranes used without an electric field had no rejection ability of the solutes. When the electric field was applied, the permeate was concentrated or diluted according to the charge of the solute and the electric potential gradient. The effects of the operating conditions, such as applied pressure, feed flow rate and applied electric field strength, on rejection were experimentally studied in single-solute and mixed-solute solutions.
The experimental results showed that EUF and EMF were effective for the separation of charged solutes such as amino acids and proteins in both single-solute and mixed-solute solations.抄録全体を表示PDF形式でダウンロード (832K)
- |<
- <
- 1
- >
- >|