巻号一覧
24 巻, 1 号
選択された号の論文の10件中1～10を表示しています
- |<
- <
- 1
- >
- >|
-
藤本 豊士, 野村 隆士, 青木 武生, 向後 寛1999 年 24 巻 1 号 p. 2-8
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーCaveolae and rafts are two different domains of the plasma membrane. Caveolae are small invaginations and characterized by the presence of unique membrane proteins named caveolins. Caveolins bind cholesterol, form oligomers, interact with various signaling molecules, and induce caveolae formation. On the other hand, rafts are highly dynamic structure and do not take any characteristic shape; but both caveolae and rafts are enriched with sphingolipids and cholesterol and appear to contain many molecules in common. Some of the functions which have been ascribed to caveolae, such as signal transduction, may be mediated by both caveolae and rafts. Caveolins are thought to be involved in the intracellular cholesterol transport, and an increase or decrease of cholesterol content appears to affect caveolae and rafts. Mutation of caveolin genes or quantitational change of caveolae and caveolins has been reported to occur in several diseases. Further studies should elucidate the physiological roles as well as pathological changes of these functional domains in the plasma membrane.抄録全体を表示PDF形式でダウンロード (1296K) -
飯野 正光1999 年 24 巻 1 号 p. 9-14
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーFor the intricate regulation of spatio-temporal patterns of Ca2+ signalling, intracellular Ca2+ stores play extremely important roles. Ca2+ stores are equipped with two classes of related Ca2+ release channels, the ryanodine receptor (RyR) and the inositol 1, 4, 5-trisphosphate receptor (IP3R). The RyR functions as a Ca2+ signal amplifier by receiving information form the L-type Ca2+ channels on the surface membrane and inducting the release of Ca2+ from the striated muscle sarcoplasmic reticulum. The IP3R is often involved in the generation of Ca2+ wave, which seems to be the results of regenerative Ca2+ release due to Ca2+ dependence of the IP3R activity. The activation of the IP3R often results in the generation of Ca2+ oscillation, which is implicated in the regulation of efficacy and specificity of Ca2+ signalling. With the advent of Ca2+ imaging technique and the employment of various molecular biological strategies, the mystery of Ca2+ signalling is now being unraveled.抄録全体を表示PDF形式でダウンロード (853K) -
矢田 俊彦1999 年 24 巻 1 号 p. 15-22
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーIn pancreatic β-cells, the role of endoplasmic reticulum (ER) in the regulation of cytosolic Ca2+ concentration ([Ca2+] c) is not thoroughly understood. Moreover, the dynamics and functional role of mitochondrial Ca2+ ([Ca2+] m) as well as the interactions between ER, mitochondrial and cytosolic Ca2+ have largely been unknown. We developed a method of measuring [Ca2+] m in the insulin-secreting MIN6 cells using recombinant aequorin targeted to mitochondria, while monitoring [Ca2+] c by fura-2. In rat β-cells, glucose induced an initial decrease in [Ca2+] c, followed by an increase in [Ca2+] c due to inhibition of KATP channels and Ca2+ influx. The decrease in [Ca2+] c was due to activation of the thapsigargin-sensitive ER Ca2+-pump and Ca2+ sequestration by ER. The glucose-accelerated Ca2+ sequestration was coupled to an enhanced Ca2+ release from ER by ACh. cAMP-PKA pathway, when [Ca2+] c was elevated, also stimulated Ca2+ sequestration due to activation of ER Ca2+-pumps. In aequorin-expressing MIN6 cells, ATP induced transient increases in [Ca2+] c and [Ca2+] m. KCl (22 mM) induced a sustained increase in [Ca2+] c but a transient increase in [Ca 2+] m. The peak [Ca 2+] m response reached 1-3 μM, while that of the averaged [Ca2+] c was 300-800 nM. Therefore, microdomains with very high Ca2+ may exist in cytosol and be responsible for the transport of Ca2+ into mitochondria. Glucose induced oscillations of [Ca2+] c and, concomitantly, oscillatory and/or sustained increases in [Ca2+] m most likely result in the continuous activation of TCA cycle enzymes and ATP production, thereby leading to sustained secretion of insulin.抄録全体を表示PDF形式でダウンロード (917K) -
川野 誠子1999 年 24 巻 1 号 p. 23-30
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーCa2+ signals in the nucleus play important roles in various functions, such as gene transcription, protein transport, appoptosis, and diseased states. It has long been accepted that Ca2+ freely flows by diffusion through nuclear pore complex (NPC) between cytosol and nucleus. Recently, however, there are several evidences to support the existence of the independent regulation of nuclear Ca2+. The presence of Ca2+ signaling molecules in nuclear envelope (NE), Ca-ATPase Ca2+ pump, IP3 receptor, IP4 receptor and ryanodine receptor, and the existence of nucleo-cytoplasmic Ca2+ gradients are identified. It is indicated that nuclear envelope may serve as a barrier to cytosolic Ca2+ changes and function as the Ca2+ store to sustain the propagation of Ca2+ signals through the nucleoplasm. In this paper, I would like to introduce the recent studies about Ca2+ transporting systems of the NE, cross-talk between cytosolic and nuclear Ca2+ pools, and the regulation of NPC.抄録全体を表示PDF形式でダウンロード (1266K) -
中尾 真一1999 年 24 巻 1 号 p. 31
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーPDF形式でダウンロード (174K) -
諸岡 成治, 中尾 真一, 浅枝 正司1999 年 24 巻 1 号 p. 44-45
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーPDF形式でダウンロード (233K) -
上宮 成之, 草壁 克己, 中尾 真一, 山口 猛央, 原谷 賢治, 都留 稔了, 浅枝 正司, 喜多 英敏, 諸岡 成治, 増田 隆夫, ...1999 年 24 巻 1 号 p. 46-61
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーPDF形式でダウンロード (2394K) -
松方 正彦1999 年 24 巻 1 号 p. 62-63
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーPDF形式でダウンロード (299K) -
森田 啓之1999 年 24 巻 1 号 p. 64-71
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーThe mammalian liver is not only a metabolic, storage, or clearance organ but also contains many receptors, now shown to include osmoreceptors, baroreceptors, ionic receptors, and glucose receptors.In this paper I review physiological and pathophysiological roles of hepatoportal Na-sensitive mechanism. Na consumed orally is absorbed from the intestine into the blood and circulates in the hepatic vasculature first, then go into the systemic circulation. The hepatoportal Na-sensitive mechanism is triggered by the increase in portal venous Na concentration in advance of changes in systemic blood Na concentration and reflexively control Na appetite, Na absorption, and Na excretion. Furthermore, the hepatic blood flow is -25% of the systemic blood flow. Thus the hepatoportal Na-sensitive mechanism can detect amplified Na changes, whereas once absorbed Na enters into the systemic circulation, it is diluted by five times. Therefore, the hepatoportal Na-sensitive mechanism may predict changes in systemic blood Na concentration on the basis of amplified changes in portal Na concentration, then control body fluid Na homeostasis in a prospective manner.抄録全体を表示PDF形式でダウンロード (988K) -
廣瀬 雅彦1999 年 24 巻 1 号 p. 72-75
発行日: 1999/01/01
公開日: 2011/03/04
ジャーナル フリーThe ultra-low pressure NF membrane module “LES90” has a high productivity under an operating pressure of 0.5 MPa. The NaCl rejection of “LES90” is 95% and permeate flow is 28m3/day at 0.5MPa. “LES90” is a crosslinked fully aromatic polyamide composite membrane, so it has a high resistance to chemical washing materials. “LES90” can be economically used in the desalination of brackish water and in the concentration of relevant materials from contaminated liquids at food processing plants.抄録全体を表示PDF形式でダウンロード (475K)
- |<
- <
- 1
- >
- >|