MEMBRANE
Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
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Volume 39, Issue 5
Displaying 1-12 of 12 articles from this issue
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Special Topic:Plenary Lecture in 36 Annual Meeting
Review Article
Special Topic : Symposium on biomembranes “Development of nanoparticles consisting ofunique biomembranes for DDS”
Review Article
  • Development of DDS Using the Interaction of TumorMicroenvironment–responsive Device with Lipid Membrane
    Susumu Hama, Kentaro Kogure
    2014 Volume 39 Issue 5 Pages 277-282
    Published: 2014
    Released on J-STAGE: May 14, 2015
    DOIhttps://doi.org/10.5360/membrane.39.277
    JOURNAL OPEN ACCESS
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    Ideal cancer therapy without side effects would be achieved by drug carriers, which can deliver anticancer drugsspecifically to cancer cells in tumor tissue. Thus, it is necessary to control both the biodistribution and cellularuptake of drug carriers. For this, physicochemical properties, especially surface charge of drug carriers, are impor-tant. Negative charge of carriers is favorable to avoid interaction with biogenic substances, which results in effectivebiodistribution. In contrast, positive charge is required for effective cellular uptake. Therefore, conversion of the car-rier surface charge from negative to positive in response to tumor microenvironment is expected to cause effectivedelivery of drugs to target cells. In this article, we introduce novel charge–invertible nanoparticles responding tumormicroenvironment.
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  • The Bio–nanocapsule: Versatile Liposome Armed with Virus–derived Functional Domain
    Shun’ichi Kuroda
    2014 Volume 39 Issue 5 Pages 283-289
    Published: 2014
    Released on J-STAGE: May 14, 2015
    DOIhttps://doi.org/10.5360/membrane.39.283
    JOURNAL OPEN ACCESS
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    Some viruses that have nanoscale particle structures and infect humans can evade the recognition by the reticu-loendothelial system, circulate in blood stream, adsorb onto specific target cells, and finally enter into the cells. Theconsecutive actions strongly suggested that these viruses are naturally occurring nanomachines possessing the fol-lowing properties concurrently, stealth activity, targeting activity, and cell–penetrating activity. Since these proper-ties are caused by their envelope proteins, they can be applied for the design of efficient nanocarriers by incorporat-ing functional domains of their envelope proteins. In this review, we describe the development and utility of bio-nanocapsules, hybrids of human liver–specific hepatitis B virus envelope proteins and liposomes, as a drug deliverysystem. By modifying the surface of bio–nanocapsules with a variety of recognition molecules (e.g., antibodies,sugar chains, homing peptides), the technology can be used for targeting other organs.
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  • Application of Surface–modified Liposomes with Succinic Acid for Drug Delivery System Targeting Bone Marrow
    Keitaro Sou
    2014 Volume 39 Issue 5 Pages 290-295
    Published: 2014
    Released on J-STAGE: May 14, 2015
    DOIhttps://doi.org/10.5360/membrane.39.290
    JOURNAL OPEN ACCESS
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    The capsular structure of liposomes is attractive for encapsulation of pharmaceuticals to develop nanoparticle-based drug delivery systems. Here unique liposomes which are modified with succinic acid on their surface arereviewed at a point of view of drug delivery carriers. The negatively charged carboxyl group of the succinic acid onthe surface of the liposomes contributes to facilitate the formation of the unilamellar liposomes which have superiorability to efficiently encapsulate the pharmaceuticals. Interestingly, we found that the liposomes modified with suc-cinic acid are highly distributed in the bone marrow through the intravenous injection. These characteristics of thesurface–modified liposomes with succinic acid would be applicable for the drug delivery system targeting bone mar-row.
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  • Development and Biomedical Applications of Polymeric HollowCapsules “PICsomes”Possessing Semipermeable Polyion Complex Membrane
    Akihiro Kishimura
    2014 Volume 39 Issue 5 Pages 296-301
    Published: 2014
    Released on J-STAGE: May 14, 2015
    DOIhttps://doi.org/10.5360/membrane.39.296
    JOURNAL OPEN ACCESS
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    In this article, recent progress of polyion complex vesicles, PICsomes, were reviewed, particularly focusing ontheir design strategy, preparation and material–loading methods, characteristic properties, and biomedical applica-tions.
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Special Topic : Frontiers of Membrane Structure Analysis: From Biomembranes,
Review Article
Review Article
Channel-Membrane Interactions: An Insider Report by the KcsA Potassium Channel
Special Topic : Membrane Award for Young Scientists (2014)
The Transporter-mediated Regulation of Prostaglandin Signaling
Original Contribution
Mercury (II) Ion Transport Across Polyallylamine Membrane fixed with Thymine
  • 【Original Contribution】 Mercury(II)Ion Transport Across Polyallylamine Membrane fixed with Thymine
    Tatsuo Kurokawa, Itaru Okamoto
    2014 Volume 39 Issue 5 Pages 337-343
    Published: 2014
    Released on J-STAGE: May 14, 2015
    DOIhttps://doi.org/10.5360/membrane.39.337
    JOURNAL FREE ACCESS
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    Polyallylamine (PAA)membrane fixed with thymine, one of a nucleic acid base which binds to a mercury (II)ionselectively was made by dehydration condensation of the thymine 1–acetic acid to PAA. The flux of a mercury (II)ion and a transport selectivity of a mercury (II)ion over a copper (II)ion were estimated by the transport experimentacross the polyallylamine (PAA)membrane fixed with thymine. As compared with the membrane which does nothave thymine, the flux of the mercury (II)ion became 1.8 times larger by the PAA membrane fixed with thymine.The transport selectivity over the copper (II)ion of a mercury (II)ion became 1.8 times by reduction treatment of thePAA membrane fixed with thymine. By the reduction of the membrane, since the complexing site of a mercury (II)ion increased, the selectivity of a mercury (II)ion increased. Since the concentration in the membrane of the mercu-ry (II)ion was 3.3 times that of the copper (II)ion, the mercury (II)ion forms the complex more stable than the cop-per ion in the PAA membrane.
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Products Spotlight
  • Large Diameter UF Membrane “FILTUBE”
    Toshihiro Tamai
    2014 Volume 39 Issue 5 Pages 344-347
    Published: 2014
    Released on J-STAGE: May 14, 2015
    DOIhttps://doi.org/10.5360/membrane.39.344
    JOURNAL RESTRICTED ACCESS
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    A new tube-like UF membrane “FILTUBE”was developed. Since it has 4mm of inner-diameter, larger than con-ventional hollow fiber membranes, “FILTUBE”achieves both in-to-out filtration of high turbidity wastewater andeasy maintenance of membrane by automated back-washing. And “FILTUBE” water-treatment system, its standsoutside of raw water tank, can be easily installed into existing water-treatment plant, compare with conventional sub-merged type membrane water treatment system.
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