巻号一覧
8 巻, 1 号
選択された号の論文の6件中1～6を表示しています
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中島 元夫, 入村 達郎, Garth L. Nicolson1983 年 8 巻 1 号 p. 2-14
発行日: 1983/01/01
公開日: 2011/03/04
ジャーナル フリーMucopolysaccharides (i.e., glycosaminoglycans) have recently been implicated with various aspects of tumor cell-host interactions. First, the presence of tumor cell-associated mucopolysaccharides may be related to the regulation of cellular growth and invasiveness of tumors. Particular mucopolysaccharides seem to play specific roles at the tumor cell periphery. For example, the mucopolysaccharide heparan sulfate (HS) has been shown to be structurally heterogeneous mainly due to the differences in 6-O-sulfation and N-sulfation of glucosamine, and the variations in HS sulfation have been found to be tissue specific and related to the malignant potentials of tumor cells. Qualitative and quantitative changes in HS may affect the microenvironment of cells and modify cellular interactions, growth and differentiation. Secondly, glycosaminoglycans such as HS constitute a major fraction of the endothelial cell basement membrane which acts as a barrier against the invasion of blood-borne tumor cells. We have found that metastatic tumor cells with high lung colonization potentials possess specific abilities to degrade both HS proteoglycans in the basal lamina-like matrix of cultured endothelial cells and purified, soluble lung HS. This observation may explain how metastatic tumor cells migrate through the vascular wall and develop metastatic lesions in distant, often specific, organ sites. In this review we discuss the roles of tumor cell-associated mucopolysaccharides and mucopolysaccharide degrading enzymes in tumor cell-host interactions which lead to metastasis.抄録全体を表示PDF形式でダウンロード (2593K) -
辻田 義治1983 年 8 巻 1 号 p. 15-23
発行日: 1983/01/01
公開日: 2011/03/04
ジャーナル フリーGas permeabilities of polypeptide membranes, poly-γ-benzyl-L-glutamate with some solid state modifications, poly-β-benzyl-L-aspartate of α and ω helices, and poly-γ-benzyl glutamate of racemic form, are discussed. The steady state permeability coefficients and diffusion coefficients change discontinuously on a first order transition which is caused by either breakdown or formation of regular side-chain structures of polypeptides. The regular side-chain structures such as stacking between benzene rings observed in the form A of poly-γ-benzyl-L-glutamate, the ω helix form of poly-β-benzyl-L-aspartate, and the racemic form of poly-γ-benzyl glutamate reduce the steady state permeability coefficients, diffusion coefficients, and solubility coefficients.抄録全体を表示PDF形式でダウンロード (1175K) -
松浦 剛1983 年 8 巻 1 号 p. 24
発行日: 1983/01/01
公開日: 2011/03/04
ジャーナル フリーPDF形式でダウンロード (159K) -
山下 亀次郎1983 年 8 巻 1 号 p. 25-30
発行日: 1983/01/01
公開日: 2011/03/04
ジャーナル フリーIt is now widely accepted that thyroid-stimulating antibodies are found in the blood in most, if not all, patients with Graves' disease. Long-acting thyroid stimulator (LATS) was the first such activity to be described. Subsequently, long-acting thyroid stimulator protector (LATS-P) was discovered : this activity was demonstrated in most patients with Graves' disease.
In vitro, increased cyclic AMP production in human thyroid tissues after incubation with the patient's serum indicates that a thyroid adenylate cyclase stimulator is present in the serum. Recently, the radioreceptor assay measures the inhibition of 125I-TSH binding to thyroid cell membranes by the sera of Graves' disease. On the other hand, high levels of basal adenylate cyclase activity in the thyroid tissue from the patients especially with possitive thyroid stimulators were reported.
These lines of observation suggest that Graves' thyroid tissue may be stimulated by abnormal thyroid stimulators. From these points of view, I discussed in this article on the etiology of Graves' disease.抄録全体を表示PDF形式でダウンロード (951K) -
Hisako Tagaya, Akira Watanabe1983 年 8 巻 1 号 p. 31-38
発行日: 1983/01/01
公開日: 2011/03/04
ジャーナル フリーThe Interfacial isoelectric point (IEP) of lipids was obtained by using electrocapillary phenomena at oil/water interfaces. The value of IEP was found to be influenced by the presence of inorganic electrolyte or antibiotics in the aqueous phase. These changes were explained by the competition counterion binding or by the change in the interfacial pH. These effects were influenced by the penetration of cholesterol into the adsorbed lipid layer. The interfacial isoelectric point of bovine serum albumin (BSA) was found to be 5.279 ± 0.003 by the same method. The counterion binding also took place in the case of BSA.抄録全体を表示PDF形式でダウンロード (800K) -
栗秋 政光, 原田 達夫1983 年 8 巻 1 号 p. 39-45
発行日: 1983/01/01
公開日: 2011/03/04
ジャーナル フリーThe temperature dependence of physical properties was investigated for two different types of cross-linked hydrogel membranes, prepared from 2-hydroxyethyl methacrylate (HEMA) /methyl methacylate (MMA) copolymer system and from N-vinyl pyrrolidone (N-VP) /MMA copolymer system. The water content for the N-VP/MMA copolymer decreased in a temperature range from 0°C to 90°C, but for the HEMA/MMA copolymer it first decreased to approximately 55°C and then increased at higher temperatures. The change in oxygen permeability with rising temperature showed the same behavior as water content of hydrogels, because of permeation being due to water transport through swollen hydrogels. The retractive force of the N-VP/MMA copolymer on small strain below Λ=1.50 increased with rising temperature, on larger strain a retractive force minimum was found at approximately 70°C, where Λ=L/Lo; with L being the stretched gel strip length and Lo being the unstretched length. Under conditions of osmotic equilibrium, Warren and Prins observed a tensile load maximum at 55°C for a specimen held at constant length on HEMA gels. The results obtained in this study were contrary to their observation : a plot of the retractive force against temperature was found to show a minimum at approximately 55°C.
Hydrogels of varying water content were prepared to investigate the relationships between water content and oxygen permeability, between water content and tensile load and between water content and refractive index. Poly (HEMA), HEMA/MMA copolymer and N-VP/MMA copolymer were formulated to give hydrogels with water content from approxi-mately 23% to 82%.抄録全体を表示PDF形式でダウンロード (781K)
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