Movements of ions such as H
+, Cl
-, Na
+, K
+, Ca
2+, and HCO
3- in parietal cells are summarized. (Na
+, K
+) -ATPase (Na
+/K
+ antiport), an exchange diffusion system (Cl
-/HCO
3- antiport) and a NaCl symport system exist in the serosal (basolateral) membrane of the parietal cell, whereas (H
+, K
+) -ATPase (H
+/K
+ antiport) and K
+-recycling system exist in the secretory (apical) membrane. The role and inter-connection of these ion transporting systems to produce gastric acid is elucidated from various levels of studies on gastric mucosa in vitro, gastric gland, parietal cell, gastric vesicles and artificial planar bilayer. Furthermore, hormonal regulation of acid secretion by histamine, acetylcholine, gastrin, and c-AMP in regard to ion transport is also summarized.
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