MEMBRANE
Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
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Showing 1-11 articles out of 11 articles from the selected issue
Special Topic : Reviews based on the Special Lectures in the 43rd Annual Meeting
Special Topic : Membranes and Interfaces - Understanding of Phenomena by Thermodynamic Approaches -
  • Yosuke Imai
    2021 Volume 46 Issue 5 Pages 254-260
    Published: 2021
    Released: October 05, 2021
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    Headgroup–counterion interaction was investigated in terms of counterion hydration for the adsorbed films of dodecyltrimethylammonium salts with various counterions such as DTACl, DTABr, DTABF4, and DTA2SO4. Our experimental data supported that the interaction between TA heads and divalent SO4 ions was controlled by the balance between Coulomb force and steric hydration effect. In contrast, that between TA heads and monovalent ones (Cl–, Br – and BF4–) was well explained by the capability of headgroup-counterion contact pair formation accompanied by partial dehydration.
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  • Masumi Villeneuve
    2021 Volume 46 Issue 5 Pages 261-267
    Published: 2021
    Released: October 05, 2021
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    A variety of metal ions and complex ions exist in living organisms and are involved in various biological processes. In addition to physiological and molecular biological methods, quantitative research from the viewpoint of material science is important to understand the mechanism of their uptake from the exterior environment and their function in the body. We focused on the contribution of diffusion to the mechanism of iron uptake via the iron scavenger mugineic acid in grasses: studied the interfacial properties of polyprotic iron complexes, the effect of coexisting ions, and the pH dependence of the interaction between iron complexes and membranes using model–independent interfacial thermodynamics.
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  • Norihiro Ikeda
    2021 Volume 46 Issue 5 Pages 268-274
    Published: 2021
    Released: October 05, 2021
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    Thin liquid film has been investigated by measuring the film tension as a function of independent experimental variables and analyzing the results with thermodynamic equations derived by introducing four dividing planes to define the thermodynamic quantities of bilayer as excess quantities. The film tension has been measured for the foam film of aqueous tetradecyltrimethylammonium bromide (C14TAB) and sodium bromide solution as a function of the solute concentrations. The results suggest the micro condensation of counter ions in the bilayer film of surfactant ions at the transition of common black film (CBF) to Newton black film (NBF). In addition, the film tension has been measured as a function of temperature. The excess entropy of the bilayer formation has been evaluated and confirmed to be decreased discontinuously due to the transition of CBF to NBF. This result also supports the micro condensation. Furthermore, it is demonstrated that the measurements of film tension as a function of disjoining pressure and total pressure will give us important information about the bilayer structures in thin liquid films.
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  • Hiroki Matsubara
    2021 Volume 46 Issue 5 Pages 275-281
    Published: 2021
    Released: October 05, 2021
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    Stability and thickness of the common black films (CBFs) observed in a series of ionic–nonionic mixed surfactant systems were studied based on the phase diagram of adsorbed film deduced thermodynamically from surface-tension data. It was demonstrated that the synergetic attraction between ionic and nonionic surfactants maintained the surface density of ionic surfactant high enough to stabilize CBF even when the bulk ionic surfactant concentration was considerably low. In the absence of the synergetic adsorption, the foam film thickness was determined solely by the electrolyte concentration in the bulk solution, c, which is equal to the ionic surfactant concentration, m1, in the absence of an additional inorganic electrolyte. Exceptionally, the specific interaction between ionic surfactant head groups and their counterions reduced the surface charge density greatly in the Stern layer, leading to a foam film much thinner than the one expected from m1.
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Special Topic : New DDS systems using molecular assemblies and novel materials
  • Tatsuo Maruyama
    2021 Volume 46 Issue 5 Pages 282-286
    Published: 2021
    Released: October 05, 2021
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    The great progress of supramolecular chemistry since the end of last century includes the development of supramolecular gels. In particular, spatiotemporal self–assemblies of synthetic small gelator molecules have attracted large attention because they can achieve functional properties at a designated space and time. Peptide amphiphiles, which are designed to have hydrophobic/hydrophilic balances, are typical examples of a supramolecular gelator (low–molecular–weight gelator, LMWG). An appropriate molecular design enables the self–assembly programmed to form nanofibers/nanosheets in response to a broad range of stimuli or to microenvironments. In the last decade, several groups including our group reported that LMWGs self–assembled to form nanostructures inside living cells, which induced the cell death. This article outlines our approach for the designs of LMWGs that form the self–assembly inside living cells, which controls the cell fates. The self–assembly of synthetic molecules inside living cells would lead to a novel therapeutic approach or a novel cell–selection tool.
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  • Akihiro Kishimura
    2021 Volume 46 Issue 5 Pages 287-293
    Published: 2021
    Released: October 05, 2021
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    Biomacromolecules, such as proteins and oligonucleotides have gathered much attention as next generation’s pharmaceutics. However, for further utilization of such biomacromolecules, novel formulation technologies must be more deeply developed. Considering that many of biomacromolecules are charged polymers, polyion complex vesicles, PICsomes, can be an effective tool for the development of advanced formulation for such biomacromolecules. In the present article, a novel strategy for the fabrication of protein–enriched core inside of PICsomes was reported, together with a stepwise crosslinking method for enhancement of the encapsulation efficiency. Furthermore, novel oligonucleotide–based PICsomes and other type of PICsome–based new formulation, such as incorporation of mesoporous silica nanoparticles and bilamellarized PICsomes, were also discussed.
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  • Xu Wei, Makoto Sasaki, Takuro Niidome
    2021 Volume 46 Issue 5 Pages 294-299
    Published: 2021
    Released: October 05, 2021
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    Magnesium (Mg) alloy as a bioresorbable stent in the next generation has been studied. In general, Mg alloy quickly degrades in physiological environment, therefore the control of the corrosion is essential for its clinical application. In order to improve the anticorrosive property of Mg alloy, surface treatment and modification have been widely reported. Here, we introduce hydrofluoric acid treatment of Mg alloy, biodegradable polymers, and natural polymer coatings for the drug release and the corrosion resistance of the Mg alloy stents.
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  • Yoshiro Tahara, Masahiro Goto
    2021 Volume 46 Issue 5 Pages 300-305
    Published: 2021
    Released: October 05, 2021
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    Ionic liquids (ILs) have been used in the research field of transdermal drug delivery systems. In the early research stage, ILs were reported as the solvent of the sparingly soluble drugs or the skin penetration enhancers. Subsequently, the priority was given to the biological compatibility of ILs, and ILs consisting of nature–derived molecules attracted much attention. Choline cation is the most studied candidate of biocompatible ILs, and the transdermal delivery of sparingly soluble small molecular drugs, and proteins was succeeded. Recently, a hydrophilic antigen peptide was dissolved in an oil–based skin penetration enhancer by the assist with choline–oleate IL and produced antigen–specific immune responses by transdermal vaccination in vivo. These findings suggested that the transdermal drug delivery using biocompatible ILs is the promising research field.
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Special Topic : Membrane Award for Young Scientists (2021)
  • Tatsuya Fukuta
    2021 Volume 46 Issue 5 Pages 306-311
    Published: 2021
    Released: October 05, 2021
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    The usefulness of delivery of neuroprotective agents with nano–sized liposomes has been demonstrated for treating ischemic stroke. The strategy was based on permeability increase in the blood–brain barrier (BBB) after the onset of stroke, whereas liposomal entry was still limited. As leukocytes and certain exosomes were reported to be able to pass through the BBB, we hypothesized that liposomes with similar properties to those cells/vesicles can overcome the BBB, which allows for efficient delivery of therapeutic molecules into the brain parenchyma. This review will introduce our recent findings on ischemic stroke therapy using liposomal DDS and about approaches to develop biomembrane–mimetic nanoparticles to overcome brain endothelial cell layer.
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Products Spotlight
  • Yuji Yamashiro, Kentaro Kobayashi
    2021 Volume 46 Issue 5 Pages 312-315
    Published: 2021
    Released: October 05, 2021
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    ZLD (Zero Liquid Discharge) system is adopted where waste water guidelines are very strict. And Reverse Osmosis (RO) membrane is one of the key technology to minimize operation energy. Nitto Denko launched some RO/NF products and is developing new product for this application. Nitto Denko also does application development as well and focuses on IPA and TMAH recovery from waste water in electronics industry. From some field testing, developing product, currently named UHP–RO could concentrate IPA up to 12% with under 10 MPa operation. Also according to the simulation results, RO process can reduce operation energy down to 1/4 to 1/3 comparing to conventional distillation process.
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