α-ラクトアルブミン（α-LA），ラクトフェリンおよびリゾチームの薬理作用をマウスやフェレットを用いて検討し，統合失調症治療薬のハロペリドール（Hal）の効果と比較した。マウスにおいて，Hal は，アポモルヒネ誘発立ち上がり行動を減弱させた。α-LA，ラクトフェリン，リゾチームのいずれを投与しても，アポモルヒネ誘発立ち上がり行動は，アポモルヒネ投与40分後あるいは50分後に有意に減弱した。また，α-LA あるいは，ラクトフェリンを単独投与では，顕著な影響を及ぼさない用量の Hal と併用投与するとアポモルヒネ誘発立ち上がり行動の総数は，有意に減少した。マウスに Hal を投与すると，カタレプシーを惹起した。しかし，α-LA，ラクトフェリン，リゾチームのいずれを投与しても，カタレプシーは，観察されなかった。α-LA，ラクトフェリン，リゾチームのいずれを投与しても，低用量 Hal のカタレプシー誘発作用を増強しなかった。さらに，フェレットに α-LA を反復投与するとシスプラチンにより誘発された遅延性嘔吐を減弱させる傾向が認められた。これらの結果から，α-LA 等は，弱いながら，Hal 様作用を有すると思われる。しかし，Hal の代表的副作用として知られているカタレプシーを生じさせず，また，Hal によるカタレプシーを悪化させることも無いと思われる。
Sphingomyelin (SPM) is a major lipid of bovine milk fat globules and has been attractive in its biological functions. In the epidermis, SPM is a precursor of the biosynthesis of ceramides that play a crucial role in the retention of water and permeability barrier. However, the effect of orally administrated SPM on epidermal function is poorly understood. We investigated the effect of SPM concentrate prepared from bovine milk on the water retaining function in the epidermis by the animal study and the clinical test. Thirteen week-old hairless mice were fed SPM concentrate diets for six weeks. The results showed that 504 mg/day intake of SPM concentrate improved epidermal hydration, transepidermal water loss and ceramides content. We found that 17 mg/day intake of SPM concentrate was enough to prevent water loss and retain water in the epidermis of hairless mice. A placebo-controlled randomized double-blind clinical study of the oral intake was investigated on 25 individuals. The soft capsules containing 330 mg/day of SPM concentrate were administrated to subjects for six weeks. The placebo was prepared with the same amount of phospholipids from soy beans. SPM concentrate group showed significantly higher epidermal hydration than the placebo group. The sebum amount on the skin surface tended to be higher than that of the placebo group. Subjective symptom also revealed that reflectance and elasticity were improved in SPM concentrate group. These results indicate that dietary SPM concentrate improves the water retaining function in the epidermis, and is useful for maintaining the integrity of healthy skin.
The authors received an award from the Japanese minister of Agriculture, Forestry and Fisheries. We were recognized as public sector contributors to Agriculture, Forestry and Fisheries research and development in 2010 due to the development of a new cream production method (the Ajiwai-Kodawari process). We have challenged and succeeded in developing a novel fresh cream, something which had been generally assumed to be impossible by most in the dairy sector. The new process is the combination of nano-membrane concentration and de-oxygenation of raw milk followed by skim milk separation and UHT pasteurization under low-oxygen conditions. The deoxydized separation and pasteurization process was developed based on Meiji's proprietary milk production method (known as the ‘Natural Taste Method’ for our premium ‘Meiji Oishii Gunyu’ milk.). The Ajiwai-Kodawari process provides a novel value-added cream with a strong milk taste, but without the unpleasant aftertaste arising from ordinary UHT processes. The Meiji Fresh Cream Ajiwai series, made through this process, have been extremely well received by customers and have become a favorite among confectioners and cooks including celebrity chefs. Sales have been increased consistently since its launch in May 2008. The improved flavor has been very well received, even by consumers who had avoided UHT cream previously. Meiji Fresh Cream Ajiwai has been a success by attracting new customers.