Medical Imaging Technology
Online ISSN : 2185-3193
Print ISSN : 0288-450X
ISSN-L : 0288-450X
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Volume 32, Issue 5
Displaying 1-11 of 11 articles from this issue
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Selected Papers from the JAMIT 2014 Annual Meeting ‹Papers›
  • Alzheimer's Disease Diagnosis Using Amyloid-PET with CT-based Partial Volume Correction Using SPM8
    Kei SASAKI, Norihide MAIKUSA, Etsuko IMABAYASHI, Tetsuya YUASA, Hirosh ...
    2014 Volume 32 Issue 5 Pages 323-331
    Published: 2014
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.11409/mit.32.323
    JOURNAL FREE ACCESS
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    Analysis of amyloid amount deposited to the cerebral cortex, which can be estimated from an amyloid PET image, is effective for early diagnosis of Alzheimer's disease (AD). Nevertheless, its quantifiable measure is hampered by the partial volume effect due to the low spatial resolution, because the amount of amyloid deposition is thereby underestimated. In this work, we proposed a method using SPM8 (statistical parametric mapping 8) to correct a partial volume effect of PET image and to improve its quantifiable measure of amyloid deposition amount based on high-resolution morphological information of CT image, which is simultaneously acquired by a PET/CT scanner. The procedure was applied to clinical data of nine AD patients and eleven normal volunteers, and then emphasized the difference between the normal and AD groups in SUVR (standardized uptake value ratio) values in the eight volumes of interest effective for AD diagnosis. In addition, we demonstrated the effectiveness by comparing the AUC (area under ROC curve) between the results with and without the partial volume correction.
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  • Domain Extraction of the Pleural Mesothelioma from Chest CT Image
    Kazuya ABE, Hideya TAKEO, Yoshifumi DONOMAE, Yoshifumi KUROKI, Yuuichi ...
    2014 Volume 32 Issue 5 Pages 332-337
    Published: 2014
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.11409/mit.32.332
    JOURNAL FREE ACCESS
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    Pleural mesothelioma is a pathological condition in which carcinoma cells are observed in the pleura. A tumor infiltrates a chest wall and the surface of the lungs and metastasizes. This is a factor in causing pleural effusion caused by penetration of the pleura and the dyspnea that accompanies pleural effusion. It permeates pericardium than mediastinal pleura and forms a tumors on the pericardium, heart failure caused by dystelectasis results, indicating the need for early treatment. It is difficult to discover mesothelioma through diagnosis using conventional plain X-ray images. This is partly because mesothelioma itself exhibits few initial symptoms. In this study, a method was developed for measuring individually the volumes of pleural mesothelioma regions extracted from chest CT images. Such quantification makes it possible to assess numerically the progress of symptoms and course of treatment. Verification using patient data suggests the feasibility of assisted diagnosis that uses the identification and quantitative measurement of mesothelioma regions provided by this method.
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Selected Papers from the JAMIT 2014 Annual Meeting ‹Work-in-Progress›
  • Fine Inner Imaging of Rat's Spleen by Phase-contrast X-ray CT
    Shogo ESASHI, Akio YONEYAMA, Thet-Thet- LWIN, Masaya TAGUCHI, Hiroko M ...
    2014 Volume 32 Issue 5 Pages 338-341
    Published: 2014
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.11409/mit.32.338
    JOURNAL FREE ACCESS
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    After X-ray discovery, the X-ray imaging has been used in various fields including a medical diagnosis, and detects the difference of the linear attenuation coefficient in the object. In low atomic number elements constituting the soft tissue, the difference of the linear attenuation coefficient is very low. So it is difficult to depict clear image of soft tissue using conventional X-ray imaging. Recently, phase-contrast X-ray CT with an X-ray interferometer is being developed. This imaging system detects X-ray phase shift, is approximately 1000 times higher sensitivity than conventional X-rays imaging. Thus, various internal structures of biological specimens can be visualized without usage of any contrast agents. In this study, the visualization of rat's spleen was examined by phase-contrast X-ray CT. Phase-contrast X-ray CT clearly depicted the internal structure of rat's spleen such as white pulp, red pulp and blood vessels resembling to histological image.
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  • Automated Measurement of Mandibular Cortical Width on Dental Panoramic Radiographs for Early Detection of Osteoporosis: Extraction of Linear Structures
    Kazuki HORIBA, Chisako MURAMATSU, Tatsuro HAYASHI, Tatsumasa FUKUI, Ta ...
    2014 Volume 32 Issue 5 Pages 342-346
    Published: 2014
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.11409/mit.32.342
    JOURNAL FREE ACCESS
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    Mandibular cortical width (MCW) on dental panoramic radiograph (DPR) is considered as a guideline for screening osteoporosis. We have previously developed the automated scheme for measuring MCW based on the profile of cortical bone. However, in cases of the presence of linear structures in cortex, the MCW may not be accurately measured. In this study, we propose a computerized scheme that identifies the risk of osteoporosis by measuring the dense part of cortical bones on the basis of the extracted linear structure. Our proposed scheme was evaluated by two sets of DPR obtained at Asahi University Hospital and dental clinics. Asahi cases are composed of 100 DPR including 26 osteoporotic cases based on dual energy X-ray absorptiometry (DXA). Clinic cases are composed of 458 DPR from multiple dental clinics, including 21 suspected osteoporotic cases based on the image findings by dental radiologists. Experimental results on the Asahi cases showed that the sensitivity and specificity for identifying osteoporotic patients were 80.8% and 94.6%, respectively, whereas those on the clinic cases were 90.5% and 79.2%, respectively. The automated MCW measurement technique using extraction of linear structures on DPR has a potential to identify asymptomatic osteoporotic patients and generalizability in different imaging environments.
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  • No Fixed Renal Imaging at Low Temperature Obtained by Phase-contrast X-ray CT with Cryo-chamber
    Masaya TAGUCHI, Satoshi TAKEYA, Akio YONEYAMA, Thet-Thet- LWIN, Shogo ...
    2014 Volume 32 Issue 5 Pages 347-350
    Published: 2014
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.11409/mit.32.347
    JOURNAL FREE ACCESS
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    In comparison with absorption-contrast X-ray imaging, phase-contrast X-ray imaging has approximately 1000 times higher sensitivity for detecting light elements. Using the characteristic, the phase-contrast X-ray CT have visualized biological organ fixed by formalin or ethanol without contrast agent. In the present study, using a specially developed cryo-chamber, the morphologic changes in animal model of transplanted organ were examined by phase-contrast X-ray CT. Since the renal transplant is familiar in clinical practice, rat's kidney was selected for the transplant model. Rarely, frozen of kidney occurred, so freeze-thaw kidneys were observed by phase-contrast X-ray CT, comparing to non-frozen kidney. Rats were performed anesthesia, and perfused by a transplant protection solution (Euro-Collins solution). After perfusion, kidney was removed surgically and stored within Euro-Collins solution. Phase-contrast X-ray CT image of the freeze-thaw kidneys revealed low density in cortex and outer-medulla. Pathological image of the freeze-thaw kidneys also showed the destruction of renal tubule in these regions. Thus, phase-contrast X-ray CT with a cryo-chamber enables to visualize the histological condition of transplanted kidney without contrast agents.
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