Species distribution and antifungal susceptibility of
Candida isolates at one institution were evaluated. Detection rates of fungi were examined for 5 years between 2007 and 2011. Sensitivities of fungi to amphotericin B, flucytosine, fluconazole, micafungin, itraconazole, and voriconazole were evaluated in blood culture-positive patients. A total of 3,832 fungal isolates were detected, including
Candida albicans 66.5%,
Candida glabrata 20.3%,
Candida parapsilosis 6.2%,
Candida tropicalis 5.5%, and others 1.5%. Candidemia was diagnosed in 131 patients, and
C. albicans,
C. parapsilosis,
C. glabrata,
C. tropicalis, and others were present in 42.0%, 27.5%, 16.0%, 8.4%, and 6.1% of these patients, respectively. Voriconazole had the lowest MIC
90s against
C. albicans and
C. parapsilosis (0.015 and 0.25). Micafungin had a low MIC
90 against
C. glabrata and
C. tropicalis.
C. albicans was the most common fungus in patients with candidemia. Voriconazole and micafungin were effective against
C. albicans. Amphotericin B was effective for
C. parapsilosis, and micafungin showed good efficacy against
C. glabrata and
C. tropicalis.
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