Hematological examination (hemoglobin, wbc count and wbc differential) of the A-bomb survivors within 2000m from the bomb centre in Nagasaki were performed from February to March 1956. The number of survivors examined were 3234 and the number of the controls who were simultaneously examined were 1607. They were classified in 18 groups by sex, age and acute radiation symptoms (A-with major radiation symptoms, B-without major radiation symptoms, C-controls). Within each age group, individuals were distributed according to deviations from normal values, the respective ranges being defined for each type of blood cells as indicated in the accompanying tables. One series of chi square was computed to test the differences in deviations from normal values between A, B, and C in 1956 and another series of the same tests was made for the differences between 1953 and 1956 in A, B, and C respectively. 1) The recovery from anemia and the decrease in eosinophilia are remarkable in A and B groups in 1956 comparing with 1953, subsquently there are no significant differences between the exposed and the controls in 1956. 2) Differences between A, B, and C in 1956 are also not significant for wbc count, monocytes and lymphocytes. 3) So it may be concluded that the hematopoietic injuries by the A-bomb radiation is restored to an almost normal condition in 1956, so far as concerning the peripheral blood pictures.
The present author examined the mechanism of body temperature regulation from the aspect of metabolism, measuring with Warburg's manometer the tissue respiration in the liver and brain of rabbit and rat when their body temperature was being changed under various conditions, and checked the mode of action of various substances whether direct or indirect to the tissue. (1) During the fevering by T.T.G. (polysaccharide fraction of a non-pathogenic bacterium Pseudomonas fluorescens) or typhoid vaccine, the oxygen consumption in the brain was increased directly, whereas in the liver indirectly. (2) At lowered body temperature induced by aminopyrine or chlorpromazine, as well as in the cold room, the oxygen consumption in the liver showed indirect increase, which seemed to be compensatory for heat loss, and especially chlopromazine decreased directly the oxygen consumption in the brain. (3) When body temperature was raised in the hot room, the oxygen consumption in the brain and liver decreased. (4) Though aminopyrine or chlorpromazine could inhibit the fevering by typhoid vaccine, it could not inhibit the increase of oxygen consumption in the liver which had been induced by the pyrogen. (5) For the fevering by typhoid vaccine, and its accompanying increase of oxygen consumption in the liver, and for the lowered body temperature in the cold room and its compensatory increase of oxygen consumption in the liver, the cauterization or extirpation of the adrenals showed stronger inhibitory action than extirpation of the thyroid and cutting of the abdominal sympathetic nerves (or blocking with chlorpromazine). (6) Among the above stated chemoregulating actions of the adrenals, that of cortical hormones, especially of glucocorticoid was strongest and medullary hormones showed moderate action.
As a part of the series of the studies on the influence of the artificial pneumoperitoneum on the function of autonomic nervous system, the author measured the diameter of the pupils of 520 pulmonary tuberculous patienats. The following results were obtained. 1) There were 59 (11.3%) patients with anisocoria out of all cases. 2) There were 48 (10.2%) patients with anisocoria out of 471 cases without surgical collaps therapy. 3) The patients with anisocoria were dominant in the cases with minimal lesion. In the cases with minimal and moderately advanced lesions, the diameters of pupils on the side of which the lung was affected, were larger than the opposite side. On the contrary, the pupils of far advanced cases were smaller in the affected side. 4) There were 15 (9.3%) patients with anisocoria out of 162 cases with no collaps therapy and 8 (12.5%) cases out of 64 artificial pneumothorax cases and 25 (10.2%) patients with anisocoria out of 245 cases treated with artificial pneumoperitoneum. 5) Out of 15 patients performed cavity drainage, 2 (13.3%) cases were found suffering from anisocoria and out of 31 patients performed thoracoplasty, 9 (29.1%) cases had anisocoria. The diameter of pupils on the side undergone surgical collaps therapy were smaller than the opposite side. 6) There were 18 (7.3%) cases with anisocoria out of 224 cases with pleural thickness by roentgenological examinations. There is no close relationship between anisocoria and the side of pleural thickness. 7) The anisocoria is unstable.
In 11 patients of chronic schistosomiasis and 5 rabbits of experimentally induced acute schistosomiasis, the paper-electrophoretical patterns of serum proteins were investigated. The remarkable decrease of albumin and notable increase of gamma globulin were observed in 8 patients of chronic schistosomiasis with liver cirrhosis, the diagnosis having been precisely determined on the basis of histological findings of liver biopsy, liver function tests and so on. In 3 patients with no significant histo-pathological finding, no change was observed in the pattern of serum proteins. The pattern of rabbits at 5 or 6 weeks after the percutaneous infection of cercaria, appeared to show the gradual decreased of albumin, and increases of alpha, beta and then globulin in the successive order.