Japanese Journal of Cognitive Neuroscience
Online ISSN : 1884-510X
Print ISSN : 1344-4298
Volume 19 , Issue 2
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  • Masakazu Morinaga, Takumi Shimizu, Masatoshi Yamashita, Takanobu Yamam ...
    2017 Volume 19 Issue 2 Pages 95-101
    Published: 2017
    Released: February 14, 2018
    JOURNALS FREE ACCESS

    There is a method to focus on urinary metabolites dynamics to estimate the brain monoamine nervous system activity of a human. In Homovanillic acid of Dopamine final metabolite and 3-Methoxy-4-hydroxyphenylglycol of Noradrenaline final metabolite, excretion mechanism by transporter expressed on the blood-brain barrier has been revealed, and brain-urine correlation has also been reported. On the other hand, in the 5-HT nervous system, the excretion mechanism of brain-peripheral is shown, but the association of the brain-urine of the 5-HT metabolism are not yet clarified. In the present study, we investigated the correlations between urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion levels and the brain 5-HT content. By using 5,7-dihydroxytryptamine (5,7-DHT) that is a neurotoxin, the brain 5-HT can destroy specifically. Our intention was to clarify brain-urine correlations. The results showed that after a bilateral intraventricular microinjections of 5,7-DHT, hippocampal 5-HT and 5-HIAA content (p<0.001) as well as urinary 5-HIAA excretion were decreased (p<0.001) in comparison to the vehicle-administered group. Furthermore, a strong positive correlation was observed between urinary 5-HIAA and hippocampal 5-HT and 5-HIAA content (p<0.001). In conclusion, it was revealed that the brain 5-HIAA content reflects a 5-HT content in the brain. Furthermore, urinary 5-HIAA excretion dynamics became the noninvasive biomarker of the 5-HT nervous system activity in the brain.

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