The diffuse elastic tissue disease called dermatochalasis, although very rare, are reported ten cases in Japan. One of these case, a 35 year old house wife, in this disease died and came to autopsy. Extensive histologic studies on skin and other organs demonstrated a defect of elastic fibers throughout the body. Histologic examination of the involved skin reveals swollen and irregulaly clumped of elastic fibers and calcium imbibition. The change of aortic wall, pulmonary emphysema and prolapse uteri were present.
Two cases of metastatic tumors on the scalp originated from lung developing in 60 and 61 year old Japanese women were presented. These tumors were typical adenocarcinoma histologically. On the chest X-ray film, many faint round markings were scattered in the right lower lung field of the first case, and in the second case a great nodular lesion located in the right middle lung-field. All the previous reports of the cutaneous metastasis originated from lung in Japan were reviewed.
Twenty-four cases of chlorobiphenyls poisoning had been investigated in the department of dermatology of Kurume University hospital from the 19th to 22nd Oct. 1968. Ocular symptoms of which most of patients (75%) were conscious were hypersecretion of palpebral sebum, lacrimation, swelling of the lids, reddness of the conjunctivas, poor vision, and also paresis, neuralgia in 17% and gastroenteric disorders such as poor appetite, vomiting, nausea, diarrhea in 50% of cases. The clinical skin manifestations of acneform eruptions resembled to “chloracne” and pigmentation of the skin, nails, conjunctivas and gingivae were seen in most of cases. The skin lesions were histologically characterized by hyperkeratosis, cystic dilatation of hair follicles and increasing of melanin at the basal cell layer. Sticky hypersecretion of the meibomian glands and pigmentation in mucosal membrane and nails would be more important as initial signs of peroral chlorobiphenyls poisoning. The chemical investigation of serum in the patients revealed normal liver function, but indication of hypertriglyceridemia, slight elevation of α2-globulin and decreasing of serum iron in some cases. An electron microscopic observations of chlorobiphenyls poisoned liver indicated the increasing of smooth surfaced endoplasmic reticulums and lipofuscin granules in number. A newborn of whom chlorobiphenyls poisoned woman was delivered was also examined. Hypersecretion of meibomian glands, swelling of the lids, reddness of conjunctivas and pigmentation over the whole body were found, but no disorders of liver function. It had been noted that the chlorobiphenyls poisoned baby had been released from clinical symptoms of the disease by two years after follow-up studies.
In order to investigate a genetic aspect of congenital organic anomalies of the skin, chromosome analysis of cells cultured from the leucocyte component of the bloods obtained from one case of congenital skin atrophy, nine of nevus pigmentosus, one of nevus sebaceus, nine of hemangioma, two of Pringle’s disease, two of Peutz-Jeghers’ disease, seven of Klippel-Weber’s syndrome, six of nevus Ota, three of pseudoxanthoma elasticum, were performed, revealing following results. 1) One case of nevus sebaceus showed long Y chromosome. 2) In one case of Klippel-Weber’s syndrome, the rates of appearance of hyperdiploid cells were significantly higher than control (p<0.05).
There were demonstrated Treponema-like organisms by direct fluorescein antibody technique in the popliteal lymphnodes from 4 cases of treated early experimental syphilis with long lasting reactive VDRL slide test and in the human inguinal lymphnodes from 5 of late syphilis, 3 of congenital and one of secondary (probably reinfektion) syphilis after treatment. This Treponema-like organisms were identified with Treponema pallidum from morphological and immunofluorescein technical findings. Moreover, these persistence and long durated reagin levels after treatment were seemed to indicate their vital maintenance. Persistence of these organisms in the lymphnodes or other organ were attributed to the continued persistence of antibodies on the treatment-resistant syphilis. These material lymphnodes were inoculated into normal rabbits intratestically, in order to study the virulence of those organisms, neverthless, there were not found the syphilitic orchitis and the clear increasing of anitbodies.
Biopsy specimens were taken from the pigmented lesion in 13 patients with nevus spilus and in 13 patients with Becker’s nevus. Control specimens were taken from the apparently normal skin either adjacent to the lesion or on areas elsewhere in 11 patients out of the 26 patients. The specimens were fixed in formal saline, cut at seven micra in thickness, and sections were stained with toluidine blue. Measurements were made on four sections of the dermis in each specimen, avoiding the follicular areas deliberately. The counting of mast cells in each section was made on a 2,000μ width of dermis and on a 500μ depth of dermis just below the epidermis. The average value was described, thus, as the number of mast cells per square mm of the dermis. The logarithmic expression of the number of mast cells was found to approximate the normal distribution in eash group. Changing the logarithmic expression, the sample mean was 34.8/mm2 in the control, 100.4/mm2 in nevus spilus, and 71.7/mm2 in Becker’s nevus. The unbiased estimate of population variance ranged from 0.0202 to 0.0282. The number of mast cells was estimated to increase significantly in patients with nevus spilus and with Becker’s nevus (α=0.01). The historical background of the two diseases was also discussed.
The effect of Furozin solution containing 5% MTB was examined to 36 patients of alopecia areata. Of these 36 patients, 16 were progressively effective; 4 were effective; 2 were slightly effective. The rate of availability was 61.1%. It took 2.6 weeks on an average to develop lanugo and bristle, and 3 months to complete improvement. The duration from appearance of first symptom to beginning of treatment has an influence upon the effect of therapeutics. On 17 cases treated within 2 weeks, the rate of availability was high value of 82.4%, but on the cases of old type, it was inferior and 4 patients, treated after more than four months, failed to respond to treatment. The effect also depended upon the numbers of focus. On 19 cases of mono-type, the rate of availability wes high value of 73.7% and many patients in this group completely recovered but on 6 cases of poly-type of more than several foci, it fell to low rate of 16.7%. When we used this solution as topica, no cases of side effect were showed. We considered that this solution was useful to treat alopecia areata.
Following results were obtained by our clinical study on Fusidin ointment using a double-blind method. The efficiency rate was 89.3% in the 28 cases treated with Fusidin ointment, 44.7% in the 38 cases with Penicillin G ointment and 29.6% in the 27 cases with placebo, respectively. From these results, it is evident that Fusidin ointment is effective and useful in the treatment of impetigo which is most popular cutaneous infection in children. No remarkable side effects were found.