Trichophyton rubrum-infected nails were observed with scanning electoron microscope. The nail had various shaped and sized lacunae in each part of it. Fungus elements were localized between lamellens of ventral nail and between keratin cells of hyponychium. Lacunae seemed to be formed not by invasion of fungus elements but by pressure from outside and accumulation of keratin cells in the nail bed.
Pemphigus vegetans is considered to be a variant of pemphigus vulgaris. According to Lever there are two types of pemphigus vegetans: the type of Neumann (malignant) and Hallopeau (benign). The auther has experienced a case diagnosed to be Hallopeau type. The patient is a 83 year old woman. She had first noticed erosion and pustule on left lower leg occured after burn, this area enlarged, and similar lesions had developed on inguinal region and lower abdomen. A biopsy of skin lesion was performed and a histopathologic diagnosis of pemphigus vegetans was made. She was treated with paramesone (paramethasone acetate), and cleared.
The prickle cells, which show intracellular and intercellular edema as the result of early nonspecific inflammatory changes seemed to receive viral infection. The infected cells disclosed the swelling of the nuclei and the irregular clumping of chromatin. In the cytoplasm, the retraction of the tonofilaments, enlargement of endoplasmic reticulum, decreased number of ribosome and mitochondrial swelling were noted. Acantholysis was also observed in these ballooning cells. As the infection advances, the degenration and destruction of the prickle cells appeared together with dyskeratotic cells which had clear zone between the condensed tonofialments and shrunken nuclei.
Several kinds of benign skin tumors were experimentally treated with 0.01-0.5% Bleomycin vaseline. The skin lesions disappeared successfully after the treatments in 8 of 15 cases with verruca vulgaris (53.3%), in 15 of 31 cases with verrucae planae juveniles (48.4%), in 2 of 5 cases with molluscum contagiosum and in a case of condyloma acuminatum. It is considered the above is one of the favourable treatments for these benign skin tumors.
Glutathione and vitamin C were conducted in a series of patients with verrucae planae juveniles and verruca vulgaris for 2-4 weeks. The results indicated clinical usefulness of glutathione to verrucae planae juveniles and of vitamin C to verruca vulgaris.