It is strange that “senile pigment freckle” has attracted little attention to the Japanese, European and American dermatologists although this skin disorder is frequently seen on the exposed areas of almost all aged persons. We examined biopsy specimens of these “senile pigment freckle” and observed that they showed characteristic morphorogical changes of three types. 1) Hyperpigmentation type: The main histological finding is the hyperpigmentation of the basal layer in the epidermis. 2) Lentigo type: The most characteristic features are that small clup-shaped project of epidermal cells into the dermis and many melanocytes and melanin pigments in the basal layer of epidermal club-like projection are seen. 3) Pigment incontinentia type: In this type It is noticed that little pigments in the epidermis and many macrophages in the upper part of dermis are observed. This pigment incontinentia type of “senile pigment freckle” is tne histological form that we newly found. Cliniealy, these lesions must be diffrentiated from ephehdes, junctional nevi, seborrheic keratosis, and Dubreuilh’s precancerous melanosis. It is considered that chronic actinic exposure may play a leading role in the pathogenesis of “senile pigment freckle”.
1) After being taken orally, a causal agent (hapten) is combined with the mucous membrane to form anti-hapten-mucosa antibody. 2) This antibody has chemotaxis to the orifice regions through its carrier specificity. 3) When a sensitized subject takes a causal drug orally, a new fixed drug eruption would develop on a region inflamed and congested for some time by insect bite, fungal or bacterial infection etc., because the concentration of antigen and antibody rises there. 4) The keratinocytes and dermal macrophages take the antigen-antibody complexes and give the antigenic information to the lymphocytes through the macrophages of a regional lymphnode, where the epidermis affinity antibody is much more produced.
A case of pemphigus foliaceus is presented which has had typical bullous lesions clinically and showed the presence of anti-epidermal antibody, LE cells and antinuclear antibody in the serum. The association these unusual serological phenomena in this patient suggest a basic disturbance of immunity in the pemphigus.
The first purpose of the presented paper was to provide the clinical and pathological findings of 25-years old woman suffered from SLE. The symptom was manifested during the pregnancy and the disease was exaggerated by the delivery. The second one was to discuss the relationships to the pregnancy and delivery, and the attack and exaggeration of SLE.
In order to study facilitating factors in percutaneous absorption, the influence on percutaneous absorption of an agent prepared with salicylic acid as the tracer and hydrophilic ointment and white petrolatum as the base for local cleansing with an organic solvent, bathing (using soap), heating with infrared irradiation and hot packs, frequent massage, inflammation, and skin imbitition (closed bandage) were studied.
Significance of glucoprotein can be summarized in 1) as acute phase protein in case of inflammatory diseases, 2) relation with the connect tissue in diseases, particularly AMPS, and NMPS, 3) alteration in tumors, and 4) as antigenic substance. CRP has been conventionally employed in diagnosis of inflammatory diseases, course and prognosis of disease. The experimental results obtained by the author are considered to support the significance of Om, Hp in diagnosis as acute phase reactants. Dm and Hp were found in parallel correlation with CRP while Tr peculiarly decreased in quantity in case of aggrevation of the diseases, such as collagen diseases, etc. Especially, alteration of Tf. in acute erythematodes is presumed to be related with complements or C’3 inactivator. In pathological change of the connective tissues especially in the collagen diseases, both Om and Hp increased in quantity. Among the factors for causing increase in amount of GP particularly participation of the liver reticuloendothelial system, breakdown of the skin connective tissues and depolimerisation also can not be neglected because the author observed increase in amount of Om and Hp in bullous solution of various diseases. In cases of neoplasms, Om and Hp, particularly Om increased in amount, of which significance is entirely unknown. However, higher amount was observed in cases of metastasis from visceral glandular cancers than in cases squamous cell carcinomas. It is related with kinds of carcinomatous cells and metabolism besides degree of extent of the cancer.