The neurological and psychiatric manifestations of collagen diseases, especially of SLE and periarteritis nodosa were described. One case of SLE associated with the psychiatric manifestations and choreiform movements was presented. The reports of neurological complications in the patients with SLE in Japan throughout the past 20 years were reviewed, compared with those of other countries. The incidence of neurological and psychiatric manifestations of SLE as high as that of other countries. One case of periarteritis nodosa, whose initial symptom was polyneuritis and multineuritis was also presented, and the neurological and psychiatric manifestations of periarteritis nodosa was discussed.

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Tuberculosis subcutanea fistulosa (nodular-infiltrative form) which developed on the left sub-axillary region of a 73 year-old female has been reported. Minocycline was given orally without other antituberculosis drugs for 4 months, and almost complete recovery resulted.

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Recently we have experienced a case of external dental fistula. Statistical observations have been made on 16 cases of external dental fistula seen at the Clinic of Dent-Oral Surgery, Kumamoto University Hospital for the previous 9 years. The results are as follows,
1) The male and female ratio was 1.5:1 and this condition was most frequently seen in the teens.
2) In 80% of the cases, the etiologic factor was tooth caries, especially that of the first molar. Among cases in which etiologic factors became apparent, there were more treated teeth than untreated teeth.
3) The fistula is frequently situated in the cheek along the mandibule near the affected tooth.
4) Clinically three types of external dental fistula are classified; the granulomatous type, the abscess type and fistula type.
5) Bacteriological examinations of pus from the fistula ware performed in 7 cases, revealing Staphylococcus epidermidis in 4 cases, all of which were untreated teeth. All of the 3 nagative cases had treated teeth.
6) It took several weeks or even several years in difficult cases to establish correct diagnosis.

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Two cases of tinea barbae were reported. Case 1-the patient was a 33 year-old man having been suffering from folliculitis on the mental region for 2 months. The eruption became worse after topical steroid therapy. The fungi were demonstrated culturally and microscopically in the pus, scales and hairs. Though the culture showed the growth of Candida tropicalis at first, Trichophyton rubrum was identified on 7th week following the treatment with BAY-b 5097. It was suggested that C. tropicalis was pathogenic fungus rather than saprophytic concomitant in this patient. Case 2-the patient was a 55 year-old man having been suffering from sycosis parasitaria caused by T. rubrum. On the day following the beginning of traetment with griseofulvin disseminated papulo-vesicular lesions were seen on the trunk and extremities. The trichophytin reaction was strongly positive. Lymphocytic blastogenesis and MIF with trichophytin were not shown in these two patients.

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The capability of guinea pig epidermis to hydrolyze DNA (RNA) has been studied. The extracts were able to degrade DNA (RNA) completely to nucleosides or further metabolites. Enzyme system which could be considered to be involved were at least endonuclease, exonuclease and phosphatase (nucleotidase). The final digestive product which could not be identified had UV absorbance around 265 nm in 0.1 N HCl. The relationship between the nuclear disappearance in stratum corneum under normal keratinization and DNA catabolism was discussed.

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A simple and rapid technique for the identification of dermatophytes is described. The procedure is composed of the followings: (1) a piece of cellophane adhesive tape (“Cellotape” made by the Nichiban Co.) is stuck on slant cultures or plate cultures, (2) pull out from the cultures, (3) stuck fast on a slide glass which a drop of staining solution is previously put on, and (4) examined under microscopy. Satisfactory results are obtained even one year after the preparation, just as in the slide culture, although it was said that the foregoing adhesive tape method was available only to a temporary observation.

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Finger tips of the keratodermia tylodes palmaris progressiva patients and the healthy women were hygrophotographically compared. The number of active sweat glands was smaller in the suffered fingers than in the normal, and the more severe the symptom, the fewer are the active glands. There was no difference between right and left hands, nor between the summer and the winter in the number of active sweat glands in the normal individuals. “Raipon F” solution (neutral detergent) showed suppression of palm sweating in immersion test. Perspiration disturbance found in this disease is supposed to be a secondary symptom.

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Sebum of the surface on forehead skin of 7 normal female adults and 12 melanosis faciei femini patents was obtained by cup method one hour after washing the face with soap at 25°C temperature and 70% moisture. Lipid from sebum were extracted by ether-methanol mixture (2:1). Total lipid in sebum was measured by potassium dichromate solution and lipoperoxide was denoted as T.B.A. (thiobarbituric acid) value. Lipoperoxide and lipoperoxide/total lipid in sebum of melanosis faciei femini were exceedingly increased and at convalesce both of them were fallen into the normal level. So we presumed the lipoperoxide in sebum of melanosis faciei femini played the part of its genesis.

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Using 41 patients with chronic urticaria, allergic constitution indexing, allergic intracutaneous test, examination on complication of other allergic disorder, blood, urine and stool examinations, glucose tolerance and gastric acidity tests, ICG, liver function, renal function, adrenocortical function and thyroid function tests, seroimmuological and immunoglobulin examinations, investigation on provoking causes of urticaria and inquiry about food habit were carried out, associated with hyposensitization therapy. The results obtained are as follows:
1) Allergic disposition or constitution was the most important factor in chronic urticaria.
2) The allergic intracutaneous test showed specific reagins in 6 cases (3 of provocative urticaria and 3 of positive P-K reaction).
3) Effects of specific hyposensitization therapy on patients having specific reagins were much satisfactory, while generally, hyposensitization therapy upon cases of chronic urticaria worked relatively.

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This report deals with laboratory studies on 33 subjects respectively undergoing PSP and other renal function tests, ICG and other liver function tests and cardiac function tests. As to cardiac function, all cases showed normal results. Among 17 subjects that in the PSP test (PSP₁₂₀) were characterized by over 85 % excretion in 120 min, 10 (59 %) revealed low excretion rates in the ICG test. Selected from these 10, 4 cases were subjected to the C_PAH test and they all manifested low RPFs. Judging from these facts, part of PSP to excrete from the liver seeems to have excreted compensatively from the kidney. The phenomenon of over 85 % excretion of PSP₁₂₀ substantiates this view. The level of excreted PSP₁₂₀ is considered to have reflected lowered excretion ability of the liver.

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Five patients with psoriasis vulgaris were treated for 7 consecutive days by ODT with 0.025% 17α-desoxymethasone ointment, 20 g. daily (5 mg. 17α-desoxymethasone), and the serum 11-OHCS and urinary 17-OHCS levels were estimated every day. Eosinophil counts and blood glucose levels were also estimated. The serum 11-OHCS and urinary 17-OHCS levels were apparently lowered in all cases from the day after the beginning of treatment on, and remained so lowered throughout the period of ODT. The phenomenon of inhibition of adrenocortical function, is transient in nature, reversing rapidly after discontinuance of ODT. Decreasing tendency of eosinophil counts and increasing of blood glucose levels were observed in some cases. The results described above indicate that the use of 0.025 % 17α-desoxymethasone ointment, 20 g. daily (5 mg. 17α-desoxymethasone), by ODT results in percutaneous absorption of 17α-desoxymethasone in an amount adequate to cause inhibition of adrenocortical function in patients with psoriasis vulgaris, etc., who have skin lesions which are suggestive of a damaged barrier zone. ODT with 0.025 % 17α-desoxymethasone ointment proved to be well clinical usefulness.

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Few reports have been published on fungicidal effects of chlorhexidine which is well recognized of its strong antiseptic activity of broad spectrum. The authors experimentally proved antifungal activity of chlorhexidine gluconate in vitro. Oronine H ointment with the principal stuff of chlorhexidine gluconate was found to be effective in 77.2 per cent of the subjects with trichophytia pompholyciformis after its therapeutic effects discussed clinically. No side effect was observed in any case of the subjects.

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