In the last 3 years nine patients with perioral dermatitis and sixteen patients with rosacea-like dermatitis have been seen at the Dermatological Clinic of Kyushu University Hospital. All patients were females with ages ranging from 18 to 61 (mean 45) and had used fluorinated steroids cream for 3 months to 10 years (mean 3 years). Perioral dermatitis seems to be a distinct entity and not a variant of rosacea-like dermatitis (steroid rosacea). All but 3 patients were greatly improved by the withdrawal of topical fluorinated steroid cream and by the tetracycline therapy for 2-3 months, although redness and atrophy lasted for 6 months to one year afterwards.
Following results were obtained by clinical and statistical analyses of the patients of contact dermatitis observed at the dermatological department of Yamaguchi University Hospital for 10 years from 1964 to 1973. 1) The outpatients observed in this period were 29, 440 in number and comprised 2, 394 cases of contact dermatitis (8.1%); 2) The incidence rate of contact dermatitis at the age decade increased in number rapidly in the second decade and remained on nearly the same level till the sixth decade. Then followed a trend of gradual decrease with increasing of age after the seventh decade. 3) Suspected contactants for the contact dermatitis of 648 patients were found to be cosmetics, drugs, plants and insects, rubber, clothes and ornaments, and soaps and cleansers. 4) by patch testing, 67.1% of 82 cases suspected of contact dermatitis due to cosmetics were proved positive for cosmetics, and basic cosmetics were found positive more frequently than makeup cosmetics; 5) of drug suspected of the contactant, topical drugs for the eczema, sterilization chemicals and disinfectants, antimycotics, and eyewashes were found to become the causative agent for contact dermatitis frequently in the order of decreasing frequency.