The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 44, Issue 2
Displaying 1-20 of 20 articles from this issue
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Color Atlas
Clinical Case Reports
  • B-Cell Lymphoma in Which Skin Lesions were Suspected to be Primary
    Yoshio TAKEUCHI, Tadahiro ONISHI, Noriaki KAMEDA
    1982 Volume 44 Issue 2 Pages 153-158
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.153
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    The patient: A 69 year old Japanese man. In June 1980, a purplish-brown pigeon egg-sized elastic hard tumor appeared on the proximal part of the extensor aspect of the left upper arm. Small hard papules on the surface of the tumor were also evident. After that, a fingertip-sized subcutaneous tumor on the right axilla and multiple fingernail-sized erythema with infiltration on the back occurred. He visited our clinic on the 8th of July. Lymph node swelling was observed on both sides on the neck, left axilla and both inguinal regions. Subpopulation of peripheral lymphocytes was T-cell 72% and B-cell 13%. Histology of the tumor on the left forearm revealed an infiltration of tumor cells mainly composed of large non-cleaved cells in the dermis and subcutaneous tissue 41% of the infitrated cells showed immunoglobulin on the cell membrane. The presence of intracytoplasmic monoclonal immunoglobulin (IgM, kappa type) in some tumor cells was demonstrated by the immunoglobulin enzyme bridging method. From these results a diagnosis of large non-cleaved cell type B-cell lymphoma was made. Eight weeks after the initiation of VEMP therapy, the tumor and other skin lesions as well ass welling of lymph nodes markedly improved. However, on the 1st of November, the patient died due to pneumonia. At autopsy, there were no tumor cells in the liver, spleen, lymph nodes or other organs. The clinical course and findings, as well as the autopsy findings indicated that the primary lesion was possibly in the skin. Nine cases of B-cell lymphoma in which skin lesions were observed have been reported in Japan. A statistical observation of these cases was made.
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  • Three Cases of Metastasizing Solar Keratosis Carcinoma
    Invasive Carcinoma Originating from Solar Keratosis
    Hiromi NARITA, Shouhei INOUE, Katsumi OGATA, Nozomu TOYAMA, Yoko AOKI, ...
    1982 Volume 44 Issue 2 Pages 159-166
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.159
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    Three cases of metastasizing solar keratosis carcinoma are reported. Case 1 was a 72-year-old male ex-farmer with a tumor (pseudoglandular SCC) on the left cheek. The tumor was removed but lymph node metastasis occurred. Radical neck dissection was performed with good results. Case 2 was an 80-year-old male ex-farmer with a tumor on the right cheek. Cryosurgery was soon followed by recurrences. He died after various treatments because of the destructive tendency of SCC. Invasion was confirmed in the lungs, liver and vena cava inferior at autopsy. Histology revealed small-celled SCC with hypertrophic solar keratosis. Case 3 was an 88-year-old female ex-farmer with a cauliflower-like tumor on the right middle finger. Lymph node metastasis to the right axilla was evident. She died after various treatments. In this paper, emphasis was placed on the concept of solar keratosis carcinoma.
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  • Three Cases of Epidermodysplasia Verruciformis
    Taro OGAMI, Makoto HORI, Fumi TORIYAMA, Tomio AKIYAMA, Kazuo SASAOKA
    1982 Volume 44 Issue 2 Pages 167-174
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.167
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    Three cases of epidermodysplasia verruciformis with malignant changes are reported. Consanguineous marriage had occurred in all three cases. Cases 1 and 2 were sister and brother. The skin changes occurred in infancy and the pigmented tumoral lesions developed after the age of 20, in each case. The histological findings of tumoral lesions are compatible with those of Bowen’s disease. Viral particles were identified using electron microscopy in the verruca plana-like lesions of case 3. No such particles were found in the lesions of malignant changes.
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  • Phenobarbital Hypersensitivity in Infectious Mononucleosis
    Toshihiko IKEYA, Hiromichi TAKAMA
    1982 Volume 44 Issue 2 Pages 175-181
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.175
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    Phenobarbital hypersensitivity in infectious mononucleosis occurred in a 10-year-old Japanese boy was reported. Clinically, there were typical features; fever, lymphnode enlargement, appearance of a typical lymphocyte (17%), elevated titer of Paul-Bunnell reaction (1:1792), and disorder of liver function (GOT 200U., GPT 315U.). Anti EB viral capsid antigen (VCA-IgG) titer rose, in maximum, to 1:1280. But anti-EBV associated nuclear antigen (EBNA) titer showed 1:80 from the beginning. Thus, the possibility that EBV may be reacted to the allergy seen with phenbarbital should be considered.
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  • A Case of Eosinophilic Pustular Dermatosis
    Katsumi OHYAMA, Kazuhito HAYAKAWA, Koichiro KAMO
    1982 Volume 44 Issue 2 Pages 182-187
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.182
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    A 19-year-old man with eosinophilic pustular dermatosis had eruptions not only on the face, neck, trunk and extremities, but also on the soles of his feet. Until recently, 66 cases of eosinophilic pustular dermatosis have been reported in the literature in Japan. In 19 (28.8%), there were eruptions on the soles where no hair follicles are present. From this high incidence of 28.8% on the sole, eosinophilic pustular dermatosis is a more pertinent diagnosis than eosinophilic pustular folliculitis.
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  • Chronic Dermatitis due to Foreign Bodies After Artificial Hair Transplantation
    Masayuki SHIMIZU, Hitoshi MIZUTANI, Kenji SUGIMOTO, Yoshiki TANIGUCHI
    1982 Volume 44 Issue 2 Pages 188-193
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.188
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    In a 28 year old man, indurative erythema with pustules at scalp developed 2 years after a hair transplant. Histological findings in the biopsy specimen revealed histiocytic, lymphocytic infiltration in the upper dermis. In the depths of the dermis, the fibroblasts resembled the structure of the inner root sheath. Electron microscopic examination of inflammatory lesion in the upper dermis revealed artificial hair surrounding the normal keratinocytic cells lacking of basal lamina.
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Clinical and Investigative Report
  • Enzymatic Studies on Porphyria
    I. Comparative Studies on the Erythrocyte δ-Aminolevulinic Acid Dehydrase Activity in Humans, Mice and Guinea Pigs
    Fumio MURAYAMA
    1982 Volume 44 Issue 2 Pages 194-201
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.194
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    To elicidate the mechanism of porphyrias, it is necessary to clarify the activities of all enzymes related to porphyrin biosynthesis. As a link in the chain of the studies, erythrocyte δ-aminole-vulinic acid dehydrase (ALA-D) activities were measured. The mean values of the erythrocyte ALA-D activity of mice, humans and guinea pigs were 0.37, 0.77 and 2.49μmol PBG/ml pcv/h, respectively. These activities increased in proportion to the erythrocyte protoporphyrin (PP) levels. The mean value of the human erythrocyte ALA-D activity was 0.78μmol PBG/ml pcv/h in males, and 0.62μmol PBG/ml pcv/h in females. There was no significant differences between the activities of both sexes, statistically. The erythrocyte ALA-D activity in griseofulvin (GF)-fed mice (GF induced protoporphyria) did not differ from that of a control group statistically. But, the erythrocyte PP levels were remarkably elevated in the GF-fed group, compared with the control. In guinea pigs, the activity of erythrocyte ALA-D showed no difference compared with a control group. However, the erythrocyte PP levels were elevated in GF-fed group of guinea pigs, compared with the control groups. Thus the ALA-D activity may represent factors related to porphyrin metabolism rather than to δ-aminolevulinic acid synthetase. ALA-D activity cannot therefore serve as an index of porphyrin metabolism, under abnormal conditions. The mean value of ALA-D activity in 16 samples collected from 2 patients with porphyria cutanea tarda was 0.40μmol PBG/ml pcv/h, and the activity tended to the decrease compared with a control group.
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  • Clinical Effect of Zinc Sulfate for Cutaneous Diseases
    Katsumi HANADA, Tomoko HADA, Masaaki YAMAMOTO, Shigehito CHIYOYA
    1982 Volume 44 Issue 2 Pages 202-207
    Published: April 01, 1982
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.44.202
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    Treatment with zinc sulfate was given to 40 patients with cutaneous diseases, such as acne pustulosa, psoriasis vulgaris, alopecia totalis, Buerger’s disease and eczema seborrhoicum, in which the serum zinc level was low. With the administration of zinc sulfate, many in the responsive group showed a marked increase in the serum zinc level, while those in the unresponsive group showed either a slight increase or a decrease in the serum zinc. It seemed to be difficult to determine which cutaneous disorder is the indication for zinc therapy, because of insufficient number of cases in which pronounced clinical improvement was obtained. Side effects observed during zinc therapy include gastrointestinal discomfort (6 cases, 15%), decrease of serum iron concentration (4 cases, 44%) and decrease of serum copper concentration (5 cases, 42%).
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Review
Therapy
Dermatologists around the World
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