The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 46, Issue 6
Displaying 1-17 of 17 articles from this issue
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Color Atlas
Clinical Case Reports
  • Werner’s Syndrome Associated with Hidroacanthoma Simplex
    Kazukata NISHIO, Kazuaki YANAGISAWA, Kazuhiko NOMIYAMA, Ryuji FUJIHIRA ...
    1984 Volume 46 Issue 6 Pages 1309-1315
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1309
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    We treated a patient with Werner’s syndrome associated with hidroacanthoma simplex, on the right thigh. He had been injured on his right heel and had recurrent ulcers for 6 years. Other clinical findings were hair loss, sclerosis, cataract and atrophy of the testicles. Consanguinity was present and his father and sister had had similar ailments. Laboratory examinations revealed primary hypogonadism and diabetes requiring insulin treatment. The radiography showed toe deformities and soft tissue calcifications.
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  • Sebaceous Epithelioma
    Kazuo ASO, Shigeo KONDO, Shuichi WATANABE, Yutaka HOZUMI
    1984 Volume 46 Issue 6 Pages 1316-1322
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1316
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    A sebaceous epithelioma developed on the right forhead of an 85-year-old Japanese woman, two years before she came to our clinic. Histopathological studies were done and a comparison was made with findings in a case of basal cell carcinoma with sebaceous differentiation (Rulon-Helwig) which developed from nevus sebaceous in 72-year-old Japanese woman. Clinical features of 43 cases of sebaceous epithelioma reported in the literature in Japan are summarized.
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  • Atypical Fibroxanthoma with Diabetes Insipidus
    Keiko SATOH, Yoshihiro MAEKAWA
    1984 Volume 46 Issue 6 Pages 1323-1331
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1323
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    A 61-year-old Japanese woman with atypical fibroxanthoma also had diabetes insipidus. The lesions of atypical fibroxanthoma were noted not only on the scar after an excision of plane xanthoma on the left neck, but also in the several places around the nose root and cheeks. Histopathological findings revealed a marked proliferation of variously shaped foamy cells and Touton type giant cells positive for Sudan III. There were also oval, spindle shaped fibroblastic cells and some showed an atypicality to some extent, in the deeper tissue up to even below the muscle layer. The lesions were diagnosed as atypical fibroxanthoma associated with a nodular fasciitis-like character, in some places. A clinico-pathological study was made of 16 such cases reported in Japan. The average age was 46 years, younger than that reported in some foreign countries, and the lesions in young adults occurred predominantly on the trunk and limbs. There were recurrences of lesions in 4, although no metastasis has been reported. The lesions developed after trauma in 3 cases, but there were no occurrences after irradiation therapy.
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  • Sclerodactyly with Marked Deposition of Immunoglobulin in the Dermo-Epidermal Basement Membrane Zone
    Yoriko SHIMAMOTO, Kazuhiro KATAOKA, Masaharu MIZUNO, Kenzi HORIUCHI, N ...
    1984 Volume 46 Issue 6 Pages 1332-1335
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1332
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    In a 47-year-old woman, Raynaud’s phenomenon and diffuse edematous swelling developed on all the fingers and on the backs of her hands. The lesions gradually increased with sclerotic changes. The lack of evidence of visceral organ involvement suggested that this case belonged to Barnett type 1 of progressive systemic sclerosis. In the histopathological examinations, dermal fibrosis was observed in the edematous sclerotic lesion of right index finger. Direct immunofluorescence showed marked deposition of IgG and IgM in the dermo-epidermal basement membrane zone. In the lesion with slight erythema and linear induration on the extensor aspect of right forearm, a marked deposition of IgG and IgM was observed in the dermo-epidermal basement membrane zone, despite the absence of dermal fibrosis. Although it is generally considered that the sclerotic change in Barnett type 1 occurs only on the fingers and hands, in our patient, the forearm also showed localized sclerotic changes.
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  • Incontinentia Pigmenti Achromians (Ito)
    Yukiko SAITO, Shuichi INADA, Taizo KOHNO, Yasue YOKOYAMA, Yohji FUJIMO ...
    1984 Volume 46 Issue 6 Pages 1336-1339
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1336
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    A case of incontinentia pigmenti achromians (Ito) (unilateral form) occurring in a 10 month-old girl is reported. At approximately 4 months of age, a depigmented macula appeared on the right buttock and lower extremity. Depigmented macula extended gradually on the right of the chest, abdominal wall and back, and showed band-like and marble cake-like appearance. There were no preceding skin lesions such as erythema. There were no associations with congenital anomalies and no family history of a similar disorder. Histopathological examination revealed a decreased amount of melanin granules and weakness in dopa reaction of melanocyte in the depigmented lesion. Electron microscopic examination revealed a decreased number of melanosomes and no degenerative melanosomes in the melanocytes. Steroid ointment was not effective. There has been no significant change in the depigmented macula during two years after first visit to our clinic.
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  • Friction Melanosis
    Noriko TAKAYAMA, Tadashi SUZUKI, Yumiko SAKURAI, Toshio TOMITA, Kimiko ...
    1984 Volume 46 Issue 6 Pages 1340-1346
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1340
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    The condition described herein was first noted by Muto et al. (1977). Since Tanigaki et al. (1983), the causative significance of repeated friction has been recognized. Hidano (1983) coined the term, friction melanosis. The darkening of the skin along the eminent bones, ribs for instance, is common to 69 cases hitherto reported and 5 cases here described. On histological examination, the melanophages situated around subpapillary vessels and in papillary layer is characteristic. Small deposits of amyloid occur, in certain cases, determined by staining with Dylon, after Yanagihara (1981). The presence or absence of amyloid does not interfere with the diagnosis. Along with the clinical and histological features, the presence of history of repeated friction usually with nylon towel and other nylon articles is also necessary for the diagnosis. The friction is the essential cause, though the existence of other precipitating agents is not excluded. Further investigation is needed for estimating whether contact mechanism and solar radiation may be causative or precipitating. The data of various laboratory tests including hormone assays for Addison disease, are in normal range. The most important therapeutic measure is cessation of the friction, which has been proved by Hirone (1983) to be curative.
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  • Two Cases of Congenital Cutaneous Candidiasis
    Katsutaro NISHIMOTO, Toshifumi MATSUYAMA
    1984 Volume 46 Issue 6 Pages 1347-1350
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1347
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    Two patients with congenital cutaneous candidiasis were treated. Both manifested generalized pustules surrounded by erythema within 2 days after birth. Mycological examinations of scales from both patients revealed hyphae and spores in the potassium hydroxide preparations and Candida albicans by cultures. The mother of case 1, a male baby, had had vaginal candidiasis during pregnancy and the amniotic sac had ruptured 2 hours prior to delivery. The amniotic fluid was turbid and odoriferous, but no further mycological examinations were performed. The mother of the other patient, a female baby, showed no conspicuous abnormality during pregnancy and delivery, but vaginal candidiasis was present.
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Clinical and Investigative Report
  • Hypersensitivity to Dye Additives in Sjöegren’s Syndrome
    —Reactions of Patch Test Due to Dye Additives in Various Steroids—
    Ikuyo SUZUKI, Toshikazu USUDA, Yohei IZAWA
    1984 Volume 46 Issue 6 Pages 1351-1357
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1351
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    Patch tests of dye additives were performed on 14 patients with connective tissue diseases. Five reacted to Amaranth (FD & C Red No. 2), two reacted to Erythrosine (FD & Red No. 3), one reacted to Tartrazine (FD & C Yellow No. 5) and five reacted to Sunset Yellow FCF (FD & C Yellow No. 6). The reaction was judged as positive in five patients patch tested prednisolone, in tablet form and which contained Sunset Yellow FCF. No individual had a positive reaction to prednisolone powder. The reactions of the prednisolone tablet were mainly caused by Sunset Yellow FCF used as a coloring and identifying agent. It was suggested that other contents of the prednisolone tablet caused reactions. Hypersensitivity in Sjögren’s syndrome was noticed. It is considered that the powder form of corticosteroids is safer for patients with connective tissue diseases, especially those with Sjögren’s syndrome.
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  • Antinuclear Antibody in Patients with Pemphigus
    Hideaki YOTSUMOTO, Yuko SHIMOKAWA, Hitomi ASAI, Kayoko TABUCHI, Kohei ...
    1984 Volume 46 Issue 6 Pages 1358-1360
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1358
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    Sera from patients with pemphigus vulgaris, pemphigus erythematosus and herpetiform pemphigus contained antinuclear antibody. In these sera, Sm antigen, nRNP antigen, Scl 70 antigen, SS-A antigen and SS-B antigen were examined by precipitin reaction. Autoantibodies to the antigens were not detected. The indirect fluorescent antibody technique was used to determine the nuclear staining patterns and the substrate was used with HEp-2 (from human laryngeal carcinoma). The pattern of nuclear immunofluorescence staining in the sera from pemphigus showed a speckled pattern. Thus, the sera from the patients with pemphigus contained auto-antibody to nonhistone nuclear antigens, with the exception of Sm antigen, nRNP antigen, Scl 70 antigen, SS-A antigen and SS-B antigen.
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  • Dilution of Corticosteroid Ointment
    Hiroyuki ASANUMA, Iwao TAKASHIMA, Manabu SUDO, Kiyoshi KUBOTA, Misao I ...
    1984 Volume 46 Issue 6 Pages 1361-1367
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1361
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    Commercially available 0.025% fluocinolone acetonide ointment was diluted to enhance the potency scale of the steroid. Ointment bases selected as the diluent were as follows: Simple paste, boric acid-ZnO paste, white ointment, 10% ZnO white ointment, 20% ZnO paste and 5% butyl fulphenamic acid ointment. Vasoconstriction was observed in 100% of the applications with 2 to 8 times diluted preparations. Half strength fluocinolone ointment diluted with boric acid-ZnO paste caused a marked suppression of the hypophysis-adrenal axis when applied extensively. Clinical trial of the half side test with full strength fluocinolone ointment and twice the dilution by boric acid-ZnO paste revealed a greater effectiveness of the diluted preparation. A preparation twice diluted with butyl fulphenamic acid ointment was more effective than that with 20% ZnO simple paste.
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  • An Appraisal of the Efficacy and Substantivity of New Sunscreens (III)
    Akira KAWADA, Yoshihiro MITOH, Yoshiaki SATOH
    1984 Volume 46 Issue 6 Pages 1368-1373
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1368
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    “Crème écran total 10 A+B” (RoC S. A., France) (N: light tan, and I: colourless) were evaluated for the efficacy and substantivity, indoor and outdoor. These newer sunscreens proved to be highly protective. N’s SPF (sun protection factor) for FL-SE lamp was 15 or 30, and I’s SPF was 12 or greater. Utilizing a topical PUVA procedure, SPFs of N and I for UVA determined were each 11.2. The outdoor study at Shimoda seashore (138°59’E, 34°42’N) in midsummer showed that N’s SPF against sunlight was 8.1 or greater and I’s SPF was 9.8 or greater, respectively. Based on these data, we conclude that both sunscreen preparations can be used for patients with photosensitive dermatoses, such as polymorphous light eruption, xeroderma pigmentosum, and so on.
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  • Study on Varicella-Zoster Virus in the Skin Lesions
    —Using the Cases of Double Blind Study of Acycloguanosine—
    Yusei ITOH, Yasushi WATANABE, Ryo HONDO, Yuzo AOYAMA
    1984 Volume 46 Issue 6 Pages 1374-1377
    Published: December 01, 1984
    Released on J-STAGE: March 21, 2012
    DOIhttps://doi.org/10.2336/nishinihonhifu.46.1374
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    Varicella-zoster viruses (VZV) in skin lesions were studied using the immunofluorescence method in 4 treated with acycloguanosine (ACG) or placebo in the course of double blind study of ACG. Clinically, 2 who were treated with ACG within 4 days after onset of skin lesions were cured in a remarkably short course. In the other 2 treated with placebo or ACG later than 6 days after skin eruption had a prolonged course of recovery. VZV antigen was revealed from vesicular fluid or the exsudate cell beneath the crust from 4 to 7 days after onset of skin lesions in 2 who were treated with ACG, in the early stage of the illness. Beyond the 8th day of illness, VZV antigen was not detected. In 2 recently treated with placebo or with ACG, VZV antigen was found from early to the 11th day in the former case and until the 18th day in latter case, respectively. Isolation of VZV from the vesicular fluid gave positive results only in 1 case, from 2 to 6 days after onset of skin lesions.
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Therapy
Dermatologists around the World
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