Two cases of malignant hemangioendothelioma were studied immunohistochemically using blood group specific lectin and antibody against factor VIII-R Ag. Slowly growing tumor cells in the 1st case reacted with UEA-I lectin in the early and middle stages, but ceased to react in the terminal stage. This suggests that tumor cells lost blood group H antigen when tumor advanced. Aggressively growing tumor cells in the 2nd case did not react with UEA-I, thereby suggesting that these cells lacked blood group H antigen from the beginning. Factor VIII-R Ag was not detected in either case. We conclude that blood group specific UEA-I lectin is a useful surface marker to assess the prognosis in such patients.

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We treated a 63-year-old man with alopecia neoplastica caused by a cutaneous metastasis of lung cancer. The patient had had a macular hair loss on the scalp for three months and the clinical appearance resembled that of alopecia areata. The lesion was slightly elevated, irregularly round and hard. The histology revealed adenocarcinoma in the skin and lung lesions.

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A 56-year-old man had recurrent erythematous nodules and plaques with tenderness, on his hands and feet. Laboratory data showed hyperimmunoglobulinemia A. Histologically there was leucocytoclastic vasculitis, and there was a positive deposition of C3 on the walls of capillaries in the upper dermis. Administration of DDS led to a improvement of the lesions.

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A 70-year-old woman with pemphigus erythematosus developed impetigo- and seborrheic dermatitis-like eruption on the face, chest in 1981. Small blisters were noted. At the sites of old blisters hyperpigmented macules and scaling plaques developed. Sjögren’s syndrome had been diagnosed before the appearance of eruptions. Pemphigus antibodies were positive in a ratio of 1:320, antinuclear antibodies were positive at 1:640 and anti-SS-A antibodies were positive at 1:1,024. Anti-DNA antibodies, anti-RNP antibodies, anti-Sm antibodies, anti-SS-B antibodies and LE cells were not detectable. Hypergammaglobulinemia with monoclonal immunoglobulins (IgG λ pattern) was present. Light microscopic examination of an intact bulla revealed a intraepidermal cleft containing acantholytic keratinocytes. The biopsy of the skin lesion from the back was studied by direct immunofluorescence and electron microscopic examination and IgG was identified within the intercellular substance of the epidermis, IgM was noted in the wall of small blood vessels in the papillary dermis and microtubular structure was showed in the endothelial cells of the dermal vessels. These findings suggest the close relation between pemphigus erythematosus and autoimmune diseases such as lupus erythematosus or Sjögren’s syndrome.

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A 69-year-old woman with diabetes mellitus had been treated for five or six years. In May, 1979 she was admitted to a hospital of Ichinomiya City because of dizziness, palpitation and visual disturbance. Three or four weeks after admission, she noticed eruptions with pruritus on her trunk and which were the same as that in a patient in the same room. On July 28th, she moved to a hospital of her home town for her personal convenience. On August 2nd, she consulted the dermatologic division of the Gero hot-spring hospital about the eruptions which occurred during hospitalization. The eruptions were diagnosed as eczema and treated with topical steroid ointment. In the succeeding week, the eruptions spread to her whole body except head and face and changed to papular or nodular form. In October her whole body became erythrodermic with white-gray thick scales, seen particularly on the back of hands, over the elbows and on the feet. Skin biopsy was done on November 24th, from abdominal region because of high level of LDH titer and eosinophilia. On December 1st, live scabies and eggs were isolated from thick scales on the abdomen, trunk, hands and feet. Treatment with water-soluble ointment containing 0.1% phenothrin was prescribed for two or three weeks. It cleared the scaly lesion and in 2 to 3 weeks the erythema subsided with less itching. Scabies caused by the Norwegian scabies were seen in a total 40 persons, nurses; 19, nurse assistant; 1, nurse-students; 5, patients; 11 and patient’s helpers; 4. We misdiagnosed the eruptions of scabies and considered the eruptions insect bite or eczema because they were almost all papules or seropapules scattered on the arm, trunk and inguinal regions until the proper diagnosis of the Norwegian scabies on December 1st. These scabies are transmitted by the scales of the Norwegian scabies, containing many eggs. Treatment with 0.1% phenothrin ointment cleared the eruptions for 2 or 3 weeks.

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Cases of kerion celsi experienced at the Department of Dermatology, Fukuoka University Hospital in 1981 to 1982 are reported. There were six patients all of whom were children, i. e., Case 1, 7 years and 5 months old, male, T. rubrum; Case 2, 6 years and 2 months old, male, M. canis; Case 3, 4 years and 6 months old, female, M. canis; Case 4, 15 months old, male, M. gypseum; Case 5, 13 months old, male, T. rubrum; and Case 6, 3 years and 4 months old, female, M. gypseum. During the past decade since the opening of this department (from April, 1972 to 1982), there were 23 cases of kerion celsi, from which 7 strains of M. canis, 7 strains of M. gypseum, 5 strains of T. violaceum (including T. glabrum), and 4 strains of T. rubrum were isolated as causal species. By the two year-statistical observation (1981-1982) on reported cases in Japan, 71 cases of this disease were reported. This exceeds the numbers of reported cases in Japan (159 cases) from 1976 to 1980, and accordingly, this disease is still on the increase. The species and numbers of isolated strains were 38 of M. canis, 17 of M. gypseum, 8 of T. violaceum (including T. glabrum), 6 of T. rubrum, 1 of T. mentagrophytes, and 1 of T. tonsurans, and recent causal species for kerion celsi were mostly M. canis and M. gypseum. T. violaceum (including T. glabrum) is rare, T. rubrum is decreasing and T. mentagrophytes is rare. T. tonsurans was also detected.

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A 54-year-old woman with severe ⁶⁰Co-ulcer on the left anterior chest wall was treated. She had had a left mammary carcinoma 13 years previously, therefore radical surgery and ⁶⁰Co irradiation for 3 months had been prescribed. Twelve years after the ⁶⁰Co irradiation, she had a chronic ⁶⁰Co-dermatitis with ulcer on the left anterior chest wall. Complications were necrosis of ribs, pulmonary fibrosis, cardiomyopathy and chronic, effusive, constrictive pericarditis. Because of these complications, we planned to cover the ulcer with a local flap and a tubed pedicle flap. As a result of complete removal of the necrosis and the necrotic ribs, the pulmonary pleura and the pericardium were exposed. We succeeded the covering these lesions and she discharged in a good condition.

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Previously we clinically demonstrated that a hot water extract from the adlay seed skin was effective for viral verrucae, and we isolated the active substance. The activity of this substance was determined by direct cytotoxicity test, using ⁵¹Cr-labeled K-562 as a target. The hot water extract from the adlay seed skin was extracted with a mixture of methanol and chloroform (1:2 v/v), and its soluble portion was concentrated. When separation was carried out, using a sillicagel thin-layer chromatography plate (Merck Art 5745) and a mixture of petroleum ether, ethyl ether and acetic acid (80:20:1) as a developing solution, the active substance was present at an Rf of 0.18. The scraping obtained at the Rf of 0.18 was analyzed by IR spectrophotometry, gas chromatography and GC-MS. The substance under investigation was identified as a mixture of a salt composed mainly of palmitic acid of C_16:0 and unsaturated fatty acid of C_18:0 with a small quantity of a salt of stearic acid of C_18:1 and unsaturated fatty acid of C_18:2.

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The bullae from patient with familial benign chronic pemphigus were biopsied, and the luminal surfaces were studied using scanning electron microscopy. Villi formation of dermal papillae covered by the basal cells were seen on the floor of the blister. The prickle cell layer was seen at the roof of the blister and the microvilli were usually elongated and thin. Disrupted changes were absent in the basal and prickle cells.

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From 1973-1982, 41 patients with blister diseases were examined at the Kagoshima University Hospital. Included were 8 patients with pemphigus vulgaris, 3 with pemphigus foliaceus, 4 with pemphigus erythematosus, 21 with bullous pemphigoid, 3 with dermatitis herpetiformis and a patient with benign mucosal pemphigoid. Mucous membranes were affected in 75% patients with pemphigus vulgaris and 40% with bullous pemphigoid. Characteristic itching dermatitis herpetiformis-like eruptions were observed in a patient with pemphigus foliaceus, 2 with bullous pemphigoid and 2 with dermatitis herpetiformis. Most patients with pemphigus and pemphigoid responded to corticosteroids. In patients with dermatitis herpetiformis, DDS was effective therapy. Four patients with bullous pemphigoid died, despite intensive treatment. Low levels of complement hemolytic activity, eosinophilia and hyperglobulinemia were observed more frequently in patients with bullous pemphigoid.

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One hundred and fifty seven patients with clavi seen at Kanazawa Medical University Hospital were studied statistically, with regard to age and sex. The ratio of male to female was 1:1.5 and 68% of patients were between the third and sixth decades of age. Radiological comparison of locomotion of clavi of the feet where weight was borne and not, appeared to suggest that pressure and extension of the skin over the underlying bone were involved in the development and enlargement of clavi.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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