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—Report of a Case and Review of the Japanese Literature—
Masa IWASAKI, Koutarou TSUKAMOTO, Shinichirou TAKEZAKI, Takeshi KAMOHA ...
1987 Volume 49 Issue 5 Pages
783-788
Published: October 01, 1987
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A 7-year-old Japanese boy had a cutaneous tumor on the right forehead following head trauma. Biopsy of the tumor showed infiltrates characteristic of lymphoblastic lymphoma. Results of immunohistochemical studies revealed that malignant cells had Ia, B4 and CALLA antigens on the cell surface, but not B1 antigen and cytoplasmic immunoglobulins, which are characteristics of immature B cells between lymphoid stem cells and pre-pre B cells. The patient was put on a modified LSA
2L
2 regimen for childhood non-Hodgkin’s lymphoma and complete remission was attained. Cases of cutaneous lymphoma in Japanese children are reviewed.
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Masaho HISANAGA, Shingo TSUDA, Hidemasa KAJI, Yoshio YANASE
1987 Volume 49 Issue 5 Pages
789-793
Published: October 01, 1987
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A 25-year-old man had subcutaneous nodules which persisted for 2 months on the right lower extremity and a generalized trichophytosis. Cure was attained with systemic corticosteroid and Azathioprine, for 2 years after the renal transplantation. In the KOH preparation of the scales, the pus obtained from the subcutaneous abscess and nail, mycelia were detected. A biopsy specimen was obtained from the right thigh and the cells were cultured on Sabouraud’s dextrose agar.
Trichophyton rubrum was identified. The trichophytin test, tuberculin (PPD) test and DNCB sensitizing test were negative. Griseofulvin therapy was effective.
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Naoko KATO, Ichiro KOKUBU, Fumio KANEKO, Akira OHKAWARA, Takashi MEGUR ...
1987 Volume 49 Issue 5 Pages
794-800
Published: October 01, 1987
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A 41-year-old woman had multiple arthralgia and a slowly developing disseminated eruption for ten years. For one month before the first visit and admission to our clinic, she had a high fever and sore throat. After admission, 7 signs of SLE were evident; DLE eruption, oral ulcers, arthritis, renal dysfunction, leukopenia, anti-DNA Ab and ANA. Two days after being put on 60 mg of predonisolone, she had severe abdominal pain and an acute pancreatitis was detected. Despite surgical treatment, she died. Acute bleeding pancreatitis, acute stomach ulcers, lung aspergillus infection, slight liver damage etc were present at autopsy. The relationship between acute pancreatitis and SLE is discussed.
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Shuhei FUKURO, Seiji KONDO, Akira KAWADA, Yoshiaki SATO, Yoshisada FUJ ...
1987 Volume 49 Issue 5 Pages
801-807
Published: October 01, 1987
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Three Japanese women (aged 50, 42, 41) with mild symptoms of xeroderma pigmentosum (XP) were assigned to complementation group E (XP80TO, XP81TO, XP82TO) following cell hybridization studies. All showed lowered minimal erythema between those of normal Japanese and the XP group A subjects at wavelengths of 280, 290 and 300 nm of monochromatic ultraviolet (UV) light. The delayed peak reaction of UV erythema was observed in XP80TO and 81TO. All fibroblast strains from these patients had a reduced level of 40∼44% unscheduled DNA synthesis (UDS), after irradiation with 10 J/m
2 of 254 nm UV. These cells exhibited a higher sensitivity to 254 nm UV killing [n (extrapolation number)=1.3∼1.8, D
0 (mean lethal dose)=2.2∼2.8 J/m
2] than did normal cells (n=1.5, D
0 5.0 J/m
2). None of these group E patients have neurological abnormalities. The XP80TO and 81TO subjects had basaliomas on the face at the ages of 46 and 41, respectively.
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Kimihiko MIHARA, Hidetoshi WADA
1987 Volume 49 Issue 5 Pages
808-811
Published: October 01, 1987
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An one-year-old girl had a cutaneous anomaly on the midline of her neck. The lesion extended from beneath the chin vertically down to the jugulum. The skin of the lesion was a characteristically excavated red area with a fairly thin surface and there was a tab like protrusion at the cephalic end. Neither an underlying cord formation nor fistulla was present. The child seemed to be completely normal except for this anomaly. The lesion with all the fibrotic tissue was excised and reconstruction using two Z-plasties was done with good results.
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Yasuhide TAKAHASHI, Sumi SAITO, Zenro IKEZAWA, Ryukichi NAGAI, Yuhzo K ...
1987 Volume 49 Issue 5 Pages
812-817
Published: October 01, 1987
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A 27-year-old man with psoriasis vulgaris had been under oral etretinate treatment for 5 years. The total dose of etretinate ingested was 29,140 mg. The semen analysis showed severe oligospermia; sperm count was below 5×10
4ml and sperm motility was 0%. The biopsy specimen of the testes showed a remarkable decrease of spermatogonia and spermatocytes, thickening of the basement membrane, increase in the number of Leydig cells and absence of mature spermatid. Hormonal studies were within normai limits. Inhibitish of the spermatogenesis was still evident even 8 months after cessation of the administration. Oligospermia has apparently never been reported in a psoriatic patient treated with etretinate although the reversible inhibition of spermatogenesis was noted in guinea pigs treated systemically with high doses of etretinate. Our patient also had a left varicocele but a decrease in spermatogonia was more remarkable on the right side.
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Tetsuo SANDA, Atsuko YASUE, Chiharu SUTO
1987 Volume 49 Issue 5 Pages
818-822
Published: October 01, 1987
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Two cases of tick bite are presented. At the time of first examination the case 1 patient had itchy eruptions but no ticks in the lesions. Subsequent exploration led to a diagnosis of
Haemophysalis longicornis Newmann. The case 2 patient had an asymptomatic eruption at the area where the tick was detected. This case was diagnosed as tick bite of
Ixodes persulcatus Schulze. A review of previously reported cases, including our own, suggests differences between the clinical manifestation of tick bites caused by the 2 genera of the Suborder IXODIDES (Genus Haemophysalis and Genus Ixodes).
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Taizo TAKESHITA, Hiromaro KIRYU, Yasushi SAKATA, Yuichi MIYAMOTO
1987 Volume 49 Issue 5 Pages
823-829
Published: October 01, 1987
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We treated a 61-year-old man with smoldering adult T cell leukemia (ATL) who had variable skin lesions, such as erythroderma, indurated erythema, and generalized erosions. Seventeen months after the onset, lymphoma type ATL occurred. The skin lesion was a diffuse pigmentation when diagnosed as the lymphoma type. In each subtype of ATL, suitable treatments (topic and systemic steroids,
α interferon and VEPA therapy and so on) lead to a partial remission. The patient is being closely followed outpatient division at the present time.
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Hideki HASHIMOTO, Shinichi ANSAI, Yutaka HOZUMI, Kazuo ASO
1987 Volume 49 Issue 5 Pages
830-836
Published: October 01, 1987
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A 76-year-old woman died three years after resection of a tumor on her neck. There was a metastasis to the brain and visceral organs. An 82-year-old woman had metastatic nodules on her neck, after two resections of a tumor or her left retroauricular region. In the 60 cases of sebaceous carcinoma reported in Japan, 30 had metastasis, 8 had reccurences and 16 died. From these studies as well as our own experience, we conclude that the prognosis of sebaceous carcinoma is poor, contrary to the study of Rulon et al, who found a relative benign prognosis of sebaceous carcinoma, as compared with Meibomian gland carcinoma.
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Mikio ICHIKI, Hiroshi HACHISUKA, Yoichiro SASAI
1987 Volume 49 Issue 5 Pages
837-840
Published: October 01, 1987
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Generalized atrophic, benign, junctional epidermolysis bullosa occurred in a 27-year-old man who had extracutaneous lesions in the oral cavity, larynx, conjunctiva and urethral tract in addition to generalized blister formation. Ultrastructural examination of the blisters showed a characteristic morphology of junctional epidermolysis.
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—Report of a Case and Differential Diagnosis from Keratotic Basal Cell Epithelioma and Solitary Trichoepithelioma—
Yu’ichi TERAO, Yoshie ASAI, Toshio HAMADA
1987 Volume 49 Issue 5 Pages
841-846
Published: October 01, 1987
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A 69-year-old man with trichoblastic fibroma on the posterior aspect of right thigh was treated. Histopathologically, the oval tumor contained epithelial and stromal components in the dermis. Basaloid cells, epithelial components, showed no continuity to the epidermis, and nests of basaloid cells were embedded in the fibrous stroma. Some of nests showed a protrusion-like primary epithelial germ. Cords of one or two rows of the basaloid cells were also observed. Differential diagnosis was made on both the keratotic basal cell epithelioma and solitary trichoepithelioma. The former grows rapidly and there is ulcer formation. Basaloid cells show continuity to the epidermis and cleft to stroma with inflammatory infiltration. The pattern of growth is destructive. The latter shows continuity to the epidermis with well developed, numerous horn cysts. Cords of the basaloid cells invaginate and have an immature follicular papillae. It was concluded that trichoblastic fibroma comes in the middle of these two tumors, from the grade of differantiation to the follicle.
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Kazunori YAMASHITA
1987 Volume 49 Issue 5 Pages
847-852
Published: October 01, 1987
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To investigate whether experimental protoporphyria can be induced in hairless mice, feed containing 0.5% griseofulvin (GF) was given to hairless Hos HR/De strain mice for two to four months. Protoporphyrin levels in the erythrocytes and the liver were extremely elevated, that is, protoporphyria was induced in these mice. Acute skin changes such as erythema, edema, blister and crust formation appeared after exposing the hairless mice with protoporphyria to 400 nm of light, using a metal halide lamp. Thus, hairless mice of the HR/De strain can serve as a valid model of protoporphyria. These mice are useful for macroscopic and histopathological observations of skin changes, and for photosensitivity experiments.
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Takako TAKASE, Kenichi UYENO, Atsuhiko HASEGAWA
1987 Volume 49 Issue 5 Pages
853-857
Published: October 01, 1987
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The ultrastructure of
Ceratocystis stenoceras determined by SEM and TEM was studied. Ascocarp of
C. stenoceras was round from 100 to 200
μm in diameter and was covered with mycelia, having a long slender neck from 300 to 500
μm in length. Numerous ascospores were observed on the section at the base of the ascocarp and were broad bean-like in shape from 1 to 2
μm in diameter. The wall of the ascocarp at the base was made up of two types of cells. The shape of the sympodulospores of
C. stenoceras was oval and was about 2.5
μm in diameter, as that of the
Sporothrix schenckii.
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Yukiko MIKAMI, Hideki MIKAMI, Isao HASHIMOTO
1987 Volume 49 Issue 5 Pages
858-863
Published: October 01, 1987
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Involucrin is a soluble protein precursor of the cross-linked envelope of epidermal keratinocytes and a most useful marker for the early stage of terminal differentiation. We examined the localization of involucrin, using an immunoperoxidase technique. The normal epidermis showed that involucrin was localized in the stratum granulosum and upper stratum spinosum. In the appendages, the infundibulum, the layers of the inner root sheath in the hair follicles and sebaceous ducts showed immunoreactivity for involucrin. As to the lesioned skin, proliferating lesions formed by basal oid cells (seborrheic keratosis, actinic keratosis and basal cell epithelioma) were negative for involucrin, while that formed by squamoid cells (psoriasis vulgaris, lichen planus, keratoacanthoma, Bowen’s disease and squamous cell carcinoma) show immunoreactivity for involucrin. In the squamoid lesions, patterns of staining for involucrin differed between benign lesions and malignant neoplasmas: the former showed a uniform staining but the latter showed an irregular staining of various intensities involving a patchy or patchwork-quilt pattern. Thus, involucrin aids in making a differential diagnosis of these lesions. Lichen planus and the overlying epidermis of actinic keratosis showed granular staining for involucrin, a finding suggestive of damage of the basal layer.
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—A Statistical Approach—
Masao SUWAKI, Mamoru HIROHATA
1987 Volume 49 Issue 5 Pages
864-870
Published: October 01, 1987
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Sixty-nine uremic patients requiring hemodialysis were evaluated with regard to the duration of hemodialysis, serum calcium, phosphorus, calcitonin, parathormone, urea nitrogen, creatinine, peripheral red blood cell count, eosinophils, uric acid, histamine fixability and dialyser. The rates of uremic pruritus in the hemodialysed patients in 1984 and 1986 were 79.2% and 62.9%, respectively. Statistically, only uric acid was significantly higher in the serum of the pruritic group. It appears that uricemia may be chiefly responsible for the uremic pruritus.
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Kazuo ASO
1987 Volume 49 Issue 5 Pages
871-876
Published: October 01, 1987
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67-65 Kd and their pair keratins produced in suprabasal epidermal cells have specific roles in the formation of horny keratin fiber, mainly by developing V domains in their molecules. The abnormal gene expression of these keratins in recessive and dominant hereditary palmo-plantar keratosis is indicative of these specific roles.
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1987 Volume 49 Issue 5 Pages
898-901
Published: October 01, 1987
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[in Japanese]
1987 Volume 49 Issue 5 Pages
902-911
Published: October 01, 1987
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1987 Volume 49 Issue 5 Pages
912-914
Published: October 01, 1987
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[in Japanese]
1987 Volume 49 Issue 5 Pages
915-918
Published: October 01, 1987
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[in Japanese]
1987 Volume 49 Issue 5 Pages
919-926
Published: October 01, 1987
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