The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
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Volume 62, Issue 6
Displaying 1-21 of 21 articles from this issue
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Clinical Case Reports
  • Successful Treatment of Skin Lesions of Hypereosinophilic Syndrome with Bath-PUVA Therapy
    Shigeru SUGANO, Akimichi MORITA, Yayoi SUZUKI, Takuo TSUJI
    2000 Volume 62 Issue 6 Pages 723-726
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.723
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    A 75-year-old man developed various skin lesions including: red papules, erythema, and lichenificated plaques. The lesions gradually worsened even though he was treated with conventional topical and oral therapy. Laboratory examinations revealed hypereosinophilia, which continued for over 6 months. No specific factors could be found based on the findings of laboratory and imaging analyses. Biopsy specimens of the skin lesions revealed an intense infiltration of eosinophils. These clinical and laboratory findings fulfilled the criteria of hypereosinophilic syndrome. We treated the patient with bath-PUVA therapy. After ten exposures (5.4 J/cm2), the skin lesions almost completely disappeared and the hypereosinophilia symptoms also improved.
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  • A Case of Acute Generalized Exanthematous Pustulosis Developing from Erythema Multiforme
    Kazunari USUKI, Hiroshi SARUWATARI, Hidehiko SHIMADA, Takuro KANEKURA, ...
    2000 Volume 62 Issue 6 Pages 727-729
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.727
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    A 73-year-old Japanese man with an abdominal aneurysm developed erythema multiforme and a high fever due to the administration of an antibiotic, cefazolin sodium (CEZ). Four days after onset, his eruptions changed to sterile pustules. A histological examination showed subcorneal pustules. A diagnosis of acute generalized exanthematous pustulosis developing from erythema multiforme was thus made.
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  • A Case of Eosinophilic Cellulitis Occurring after Delivery
    Miki KANNO, Atsushi HATAMOCHI, Hiroshi SHINKAI
    2000 Volume 62 Issue 6 Pages 730-732
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.730
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    A 26-year-old woman presented with multiple infiltrated erythema and swelling on her extremities which appeared 5 days after the birth of her second child. Since the histopathological findings revealed eosinophilic infiltration, a degranulation of eosinophils and a degeneration of collagen fibers in the dermis, we diagnosed this to be a case of eosinophilic cellulitis. Similar symptoms had also been observed three years earlier after her first child was born. As a result, we concluded that the birth process appeared to be the main triggering factor in this case.
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  • A Case of Pseudoxanthoma Elasticum with Angioid Streaks (Grönblad-Strandberg Syndrome)
    Reiko OFUJI, Takahiro SHIMIZU, Kazuo TOKUDA, Teruo NISHIDA
    2000 Volume 62 Issue 6 Pages 733-735
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.733
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    We report a 54-year-old Japanese male with pseudoxanthoma elasticum with angioid streaks (Grönblad-Strandberg syndrome). He manifested the typical features of skin changes and angioid streaks on bilateral fundoscopy. However, the patient did not have any other complications. The histopathological findings of a skin biopsy specimen obtained from the neck revealed the fragmentation and clumping of elastic fibers in the middle dermis.
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  • Two Cases of Hidradenoma Papilliferum
    Etsuko KOMIYAMA, Rie UEKI, Mika KOIKE, Masashi YAMASHITA, Ryoji TSUBOI
    2000 Volume 62 Issue 6 Pages 736-738
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.736
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    Two cases of hidradenoma papilliferum were observed, one in a 49-year-old subject, the other in a 35-year-old subject, and both were females. In both cases, the tumors were detected in the genital area. A review of the 53 reported cases of hidradenoma papilliferum in Japan, including the present two cases, revealed most patients to be afflicted with this condition to be females in their 30’s-50’s, and such lesions tended to mainly occur in the genital or perianal areas. The two patients in the present study were positive for both diastase-resistant PAS and CEA. A significant number of other cases suggests that the growth of this tumor is related to the apocrine apparatus; however, we believe that the site of occurrence is of greater significance in understanding the pathology of this condition.
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  • A Case of Muir-Torre Syndrome with Ocular Sebaceous Carcinoma
    Taro SHINOGI, Noriyuki MISAGO, Kayo TAIRA, Junji NAKAFUSA, Yutaka NARI ...
    2000 Volume 62 Issue 6 Pages 739-743
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.739
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    A 72-year-old woman presented with a nodule of 7 years duration on her left upper eyelid, which had grown larger in size and had also become ulcerated over the past 3 year period. The nodule was totally excised. The histopathological features of the nodule were consistent with those of ocular sebaceous carcinoma. She had a personal history of rectal cancer 4 years earlier. Based on these findings, we diagnosed Muir-Torre syndrome. No evidence of reccurrence and no development of any new neoplasms have been observed during the 2 year follow-up.
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  • A Case of Merkel Cell Carcinoma
    Reiko OFUJI, Takao UCHIHIRA, Toshiaki KAMEI, Nobuko UCHIHIRA, Takahiro ...
    2000 Volume 62 Issue 6 Pages 744-746
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.744
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    We report a 79-year-old woman who presented with the chief complaint of a pea sized nodule on her cheek. The histopathological, immunohistochemical and electron microscopic findings led to a diagnosis of Merkel cell carcinoma. An X-ray examination and computed tomography did not show any signs of metastasis. The lesion was surgically removed, and postoperatively demonstrated a satisfactory clinical course.
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  • 11 Cases of Multiple Angiolipoma
    Masami TERAUCHI
    2000 Volume 62 Issue 6 Pages 747-749
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.747
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    We report 11 cases of multiple angiolipomas (MAL) consisting of 8 men and 3 women, who were treated at our hospital from January 1992 to December 1998. Their ages ranged from 23 to 60 years of age with the average being 46.3 years. The disease seems to be most frequent in the extremities. It appears that MAL is caused by a heterology of mesenchymal multipotential cells, and it is one type of mesenchymal disease, which thus correlates with the hypothesis that MAL is a benign mesenchymoma and differs from lipoma as previously reported by Tanaka et al..
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  • Sparganosis Mansoni Revealing Annular Erythematous Plaque
    Hideaki WATANABE, Hirohiko SUEKI, Masafumi IIJIMA, Fuminori NAKAMURA, ...
    2000 Volume 62 Issue 6 Pages 750-753
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.750
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    A 57-year-old woman presented at our hospital with a pruritic erythematous plaque and a nodule on her right thigh. The lesion had repeatedly appeared and disappeared over the past three years. The lesion usually appeared once in a week, and normally continued for 1-2 days. A physical examination revealed an erythematous plaque the size of an infant’s head and a thumb-head-sized, elastic-firm subcutaneous nodule adjacent to the plaque. A skin biopsy was performed under a suspected diagnosis of collagen disease or erythema chronicum migrans. At the biopsy, we found a moving ivory-white ribbon-like worm, which was identified as a plerocercoid larva of a tapeworm of the genus Spirometra. The histopathological findings and the serum titer against plerocercoid, as measured by ELISA, supported a diagnosis of sparganosis mansoni. When we encounter a fixed erythematous plaque or nodule of unknown etiology, the possibility of parasitosis should thus be included in the differential diagnosis.
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  • Herpes Zoster with SLE in Pregnancy
    Yoko HIROTA, Hiroaki TAKAHATA, Kazue NISHIOKA, Hiroki YOSHIOKA, Masato ...
    2000 Volume 62 Issue 6 Pages 754-757
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.754
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    We report a case of herpes zoster with SLE in pregnancy. The patient was a 30-year-old woman in the thirteenth week of pregnancy who had been receiving hormone therapy for SLE. She presented with the chief complaint of pain due to skin eruptions and lymph node swelling on the right side of her neck. We recognized edematous erythema and small vesicles grouped from her right auricle to her neck and thus diagnosed herpes zoster. Although she was pregnant, we treated her with acyclovir, without any side effects. She continued the pregnancy and a normal baby was delivered at term. We also report three other cases of herpes zoster and two cases of varicella during pregnancy, which were treated at our hospital over the past three years.
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  • A Case of Tinea Corporis Caused by Trichophyton Verrucosum
    Seiji WATANABE, Toshiki FUJII, Masako KAWASAKI, Takashi MOCHIZUKI, Hir ...
    2000 Volume 62 Issue 6 Pages 758-761
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.758
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    We report a case of tinea corporis caused by Trichophyton verrucosum which occurred in a patient residing in the Noto Peninsula. A 38-year-old male veterinarian developed an erythema on his left forearm. The KOH test and microscopic examination did not reveal fungus and so we diagnosed the erythema to be nummular eczema. However, a microscopic examination of a scale taken two weeks later, revealed hypha. We identified the fungus to be T. verrucosum based on its morphology and nutritional requirements. After diagnosing tinea corporis, we prescribed terbinafine hydrochloride cream. Ten days later, the terbinafine hydrochloride had caused a worsening of his erythema. Thereafter bifonazole cream cleared-up the problem within 5 weeks.
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  • Stevens-Johnson Syndrome in an HIV-1 Carrier
    —A Probable Case Related to an OTC Drug—
    Hiroyuki TERAMAE, Takeshi KONO, Masamitsu ISHII, Shin-ichi NISHI, Shin ...
    2000 Volume 62 Issue 6 Pages 762-765
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.762
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    A 57-year-old Japanese male presented with erythematous eruptions which had extended over almost his entire body over a 2-day period after taking Dickinin®-Capsule D, an OTC for the common cold. He was admitted to the ICU of our hospital. On the initial examination, erythematous macules with bullae and erosions were found on his trunk, extremities and face. Oral and genital erosions were also observed and therefore a diagnosis of Stevens-Johnson syndrome was made, and steroids were orally and intravenously administered. However, on the day after admission, he was identified to be HIV-1 seropositive, and the lymphocytopenia advanced. The steroid treatment was rapidly tapered and human immunoglobulin was added. HHV-6, 7 DNA was not detected in the cutaneous lesions. As a result, drug induced Stevens-Johnson syndrome was therefore suspected.
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Clinical and Investigative Report
  • Significance of Laboratory Tests in Patients with Urticaria at Nagasaki University Hospital
    Ichiro KATAYAMA
    2000 Volume 62 Issue 6 Pages 766-771
    Published: December 01, 2000
    Released on J-STAGE: September 02, 2010
    DOIhttps://doi.org/10.2336/nishinihonhifu.62.766
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    A clinical analysis of laboratory tests was performed on the patients with urticaria who had been treated at the Department of Dermatology, Nagasaki University to evaluate the etiological factors and any complicated diseases. Ninety-three cases (acute urticaria 36, chronic urticaria 56) were enrolled in this study. The suspected etiological factors included upper respiratory tract infection, followed by other infections, foods, systemic diseases or other factors. An elevated CRP value was the most significant abnormal laboratory factor in both types of urticaria. Positive ANA was higher among the patients with chronic urticaria (44%) than in those with an acute form (25%). However, no patient was complicated with collagen vascular disease according to this observation. In contrast, an abnormal liver function test was demonstrated in only 10% of the patients, which was relatively lower than expected. The underlying allergic diathesis was estimated to be around 30% based on the IgE titer and positive RAST scores. These results suggest that an upper respiratory tract infection and an autoimmnue response are both possible etiolgical factors in the onset of urticaria.
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