All issues
Volume 65 (2003)
- Issue 6 Pages 541-
- Issue 5 Pages 419-
- Issue 4 Pages 319-
- Issue 3 Pages 211-
- Issue 2 Pages 115-
- Issue 1 Pages 1-
Volume 65, Issue 4
Displaying 1-16 of 16 articles from this issue
- |<
- <
- 1
- >
- >|
Color Atlas
-
Masakazu TAKAHARA, Shinichi IMAFUKU, Yuka OKUDA, Masutaka FURUE2003 Volume 65 Issue 4 Pages 319-320
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (395K)
Clinical Case Reports
-
Shiori SAIGOH, Hiromichi TAKESHITA, Kazunori URABE, Yoichi MOROI, Tets ...2003 Volume 65 Issue 4 Pages 321-323
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe report the case of a 29-year-old woman with dermatomyositis. The disease was in a remissional state when she was pregnant. But the disease relapsed at the end of 1st trimester of her pregnancy. She was started to be treated with oral predonisolone 0.5mg/kg/day. A 2028g healthy male infant was born 5 weeks earlier than expected. Generally, pregnancies complicated with dermatomyositis are considered to be high-risk. This patient is expected to have a successful delivery, however, because she was pregnant at the time of disease remission.View full abstractDownload PDF (699K) -
Hisako ENOMOTO, Yoshikazu NANNO, Junichi FURUTA, Hiroshi FUZISAWA, Sum ...2003 Volume 65 Issue 4 Pages 324-328
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSCase 1: A 78-year-old man had a 10-year history of multiple itchy nodules with histological features of prurigo nodularis, and he also suffered from several blisters on his extremities for the past 3 months with features of bullous pemphigoid. Direct immunofluorescense studies of prurigo nodularis and BP lesions showed linear depositions of IgG and C3 at the basement membrane zone (BMZ). Circulating IgG against the BMZ was also detected by indirect immunofluorescense. The patient’s serum was found to contain an antibody against the 230kD bullous pemphigoid antigen. The blisters and nodules cleared soon after oral prednisolone (30mg/day) was started. Case 2: A 77-year-old woman had a history of prurigo nodularis for 5 or 6 years, and blisters of bullous pemphigoid for 2 months. Direct immunofluorescense studies showed linear depositions of IgG and C3 at BMZ. Circulating IgG against the BMZ was also detected by indirect immunofluorescense. The patient’s serum was shown to contain antibodies against the 180kD bullous pemphigoid antigen and the 230kD bullous pemphigoid antigen. Although the blisters cleared after treatment with oral prednisolone (30mg/day), some eruptions of prurigo nodularis still remained. Considering the previous reports, it seems typical that prurigo nodularis lesions appear first and BP lesions develop later. In the diagnosis process of pemphigoid nodularis, it is important that both BP and prurigo nodularis appear at some period of the disease history, together with the immunofluorescence findings. Due to advances in the overall knowledge of bullous pemphigoid antigen, further discussions about the diagnosis, examination and treatment of pemphigoid nodularis are needed.View full abstractDownload PDF (1430K) -
Hidemichi KUBO, Takaki HASHIGUCHI, Akira GUSHI, Tamotsu KANZAKI, Tokih ...2003 Volume 65 Issue 4 Pages 329-330
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe report a case of clear cell syringoma in a 44-year-old woman with diabetes mellitus. Clear cell syringoma, which is an usual type of syringoma, is histopathologically characterized by clear cells in tumor nests. The main characteristic clinical feature of clear cell syringoma is large dome-shaped papules and this disease is often associated with diabetes mellitus. Among the 43 cases of clear cell syringoma previovsly reported in the Japanese literature, 83% cases were found to have diabetes mellitus.View full abstractDownload PDF (488K) -
Hiroshi HAMADA, Takurou KANEKURA, Tamotsu KANZAKI2003 Volume 65 Issue 4 Pages 331-332
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSThis 66-year-old man first noticed depigmentation spots on a sacral lesion when he was 30 years old. The spots gradually spread to his extremities and were non-responsive to PUVA therapy. One year prior to visiting our clinic, he noticed a depigmentation spot on his upper lip. A diagnosis of vitiligo vulgaris was made and topical tacrolimus therapy was initiated. Within 5 months, the lesions disappeared almost completely.View full abstractDownload PDF (525K) -
Seita FUKUMARU, Chiaki BABA, Hiroshi SARUWATARI, Shinichi YOTSUMOTO, T ...2003 Volume 65 Issue 4 Pages 333-335
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe report a case of leiomyoma occurring on the left nipple of a 76-year-old man. Histologically, the lesion showed bundles of smooth muscle fibers in the dermis. It appeared to have arisen from the smooth muscle of the nipple. This is the 15th case so far reported in Japan.View full abstractDownload PDF (631K) -
Atsushi FUJITA, Gen NAKANISHI, Jiro ARATA, Ritsuo NISHIUCHI, Yoshiko M ...2003 Volume 65 Issue 4 Pages 336-342
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSA 6-week-old boy developed a violaceous to erythematous tumor on his right chest and shoulder. During the following one month, it rapidly grew in size and was associated with small purpuric macules scattered over the trunk and limbs. A laboratory examination revealed thrombocytopenia and coagulopathy. Oral prednisolone 5mg/kg/day, a subcutaneous injection of interferonα-2a 3,000,000 unit/m2/day and intravenous vincristine 0.04∼0.05 mg/kg/week were not effective. As the patient’s general condition got worse, external irradiation to the tumor mass (4MvX-ray 1Gry/day × 10days: total 10Gry) was instituted. Soon after the start of this treatment, thrombocytopenia and coagulopathy improved and the tumor disappeared slowly with no remarkable side effects. Radiation therapy is considered to be a safe and useful modality in the management of life-threatening Kasabach-Merritt syndrome.View full abstractDownload PDF (1644K) -
Sonoko ITO, Keiichirou ARAI, Masukichi SAITOH, Yukihiko KATO, Tsunao O ...2003 Volume 65 Issue 4 Pages 343-346
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSIt is known that extramammary Paget’s disease (EMPD) more frequently develops in middle-aged or elderly people than in other age groups, and that it primarily affects the pudendum, anus and axillary region, which are rich in apocrine glands, but rarely occur at other sites. We recently encountered a 66-year-old male who had a fist-sized lesion of this disease in his left chest. The lesion was well-demarcated and slightly reddish-brown, with a deep reddish-brown center. A histological examination revealed a proliferation of Paget cells with bright cell bodies within the epidermis. The differences in color tone corresponded to the presence or absence of inflammatory cell invasion. The patient underwent a total resection with subsequent skin transplantation. At present, one year after surgery, he is still free of recurrence or metastasis. To date, 20 cases of EMPD affecting sites other than the pudendum, anus and axillary region have been reported in Japan, including the present case. The origin of EMPD in this case is considerd to be a pluripotential multi focal epidermal origin or the ectopic apocrine gland.View full abstractDownload PDF (1156K) -
Tomoko NAGATA, Hajime MIYAZATO, Shigeo NONAKA2003 Volume 65 Issue 4 Pages 347-350
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe report a case of venous racemous hemangioma. A 5-year-old Japanese girl visited our clinic with the chief complain of a subcutaneous nodule in her left lower leg. The lesion size measured 10×4cm with a slightly bluish color and it was elastic soft with a smooth surface. No thrill and bruit of the lesion were apparent. According to the findings of angiography, racemous proliferations were observed. As a result, this case was diagnosed to be a venous racemous hemangioma. The patient was treated with a percutaneous sclerosing technique, using 23.4% hypertonic saline solution, for the lesion. The treatment regimen was performed twice, and after the completion of the treatment, the tumor size decreasd. However, the treatment had to be terminated due to pain, and finally, a partial surgical excision of tumor was performed. There was no reccurrence for 1 year after the operation. According to a search of the Japanese Dermatological literature, only 4 cases of venous racemous hemangioma have been previovsly reported.View full abstractDownload PDF (882K) -
Manabu MAEDA, Takaharu YAMAZAKI, Mari ARAKI, Mai ENDO, Shin SASAKI, No ...2003 Volume 65 Issue 4 Pages 351-354
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSA Brazilian female case of leprosy with an annular-bordered erythema around left ear was reported. A 22-year-old female, who had come from Brazil to work one year ago, visited our division because of the occurrence of an annular-bordered erythema around her left ear of two months duration. A histopathological examination revealed small mononuclear cell infiltration nests around the blood vessels in the whole dermis with few histiocytes. A few bacillus materials with positive Fite staining were seen in the deep dermis. The PCR method using biopsied spicimen showed a 157bp band, revealing an infection by M. leprae. The clinical and histopathological features showed leprosy with a borderline group. Unfortunately, the patient stopped coming to our division for treatment and was lost to the follow-up.View full abstractDownload PDF (1109K) -
Mayumi UJIHARA, Maki YOKOGAWA, Hajime KODAMA2003 Volume 65 Issue 4 Pages 355-358
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSA 20-year-old Indonesian man visited our hospital on December 20th, 2001 because of facial lesions he had first noticed in August when working on a fishing boat since 4 months before presentation. The lesions consisted of brownish red macules with vague edges, plaques, papules and a nodule distributed bilaterally and symmetrically. They were neither anesthetic nor anhidrotic. Nervi auricularis magnus were bilaterally thickened. Acid-fast bacilli in skin and nasal smear (BI) were 4+ and 2+, respectively. A histological examination of the nodule showed a granuloma composed of histiocytes with foamy or vacuolated cytoplasm. Lymphocytes were scanty, and neither any epitheloid cells nor giant cells were recognized. Ziehl-Neelsen stain revealed many acid-fast bacilli in the histiocytes in the dermis. Acid-fast bacilli were also present in the hair follicles and sweat glands. Anti-Dharmendra antigen reaction was negative. A diagnosis of lepromatous leprosy was made and multi-drug therapy with dapsone, rifampicin and clofazimine was thus started. About 1 month later, however, he disappeared at the airport where he was brought to return to his country. We discuss the problems of treating foreign patients with Hansen’s disease living in Japan. These problems include a lack of understanding of Hansen’s disease and a high degree of prejudice against it by the general public, difficulty in building a good relationship with patients because of the language barrier, and the existence of an insufficient medical system for foreign patients.View full abstractDownload PDF (1125K) -
—Including the Follow-up Findings of the HHV-6 IgG Titer during a One-year Period—Yoshikazu NANNO, Shigeruko IIJIMA, Noriko NOGI, Mikiko TOHYAMA, Koji H ...2003 Volume 65 Issue 4 Pages 359-364
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe reported a case of hypersensitivity syndrome (HS) due to phenobarbital in a 77-year-old man. He developed an erythematous rash over the face on the 17th day after receiving phenobarbital and ticlopidine hydrochloride. Although he discontinued the latter medicine, his skin lesions worsened and became, itch while also demonstrating generalized erythroderma with heavy scaling. He also had fever, leukocytosis, eosinophilia, and liver dysfunction. Phenobarbital was also stopped, however, systemic prednisolone did not show a good response to his condition and was withdrawn. After the patient was treated with topical glucocorticoids (0.05% difluprednate ointment), his condition gradually improved. Samples of his serum and whole blood were obtained at various time points after admission (November 27, 2000) for a year. These samples were tested for human herpes virus 6 (HHV-6) IgG antibody using an immunofluorescent method, HHV-6 DNA detection using a PCR analysis, and amounts of DNA. Hypersensitivity syndrome was suggested by the titers of the above specific examination. All of them dramatically increased in our patient at admission and gradually decreased in his course during a year. A drug-induced lymphocyte stimulation test was both positive using phenobarbital (stimulation index: 257%) and ticlopidine hydrochloride(stimulation index: 210%). According to the clinical course of the patient, marked hyperactive T cells might react first with phenobarbital, and secondary with ticlopidine hydrochloride in a severely sensitive condition of the patient. We thus diagnosed the patient to have HS caused by phenobarbital, which was the most suggestive accelerating medicine that he had been administered after suffering a viral infection.View full abstractDownload PDF (1437K) -
Noriyuki HIRASHIMA, Noriyuki MISAGO, Jyunji NAKAFUSA, Yutaka NARISAWA2003 Volume 65 Issue 4 Pages 365-369
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe herein report two cases of drug-induced hypersensitivity syndrome. Case 1: A 71-year-old woman had been treated with carbamazepine for neuralgia. She developed eruptions mimicking erythema multiform and fever. The interval between the first dose of the drug and the onset of the reaction is 45 days. Titers of human herpesvirus 6 IgG antibodies dramatically increased with the development of such eruptions. Patch test of carbamazepine showed positive. Case 2: A 33-year-old man had been treated with allopurinol for hyperuricemia. The interval between the first dose of the drug and the onset of the reaction was 25 days. He developed generalized erythema and high fever. A laboratory examination revealed leucocytosis with eosinophilia, many atypical lymphocytes and renal failure and liver involvement. We diagnosed these two patients to have hypersensitivity syndrome. We think that hypersensitivity syndrome therefore presents in different types and forms.View full abstractDownload PDF (1307K)
Clinical and Investigative Report
-
Satoru HASHIMOTO, Junko KOGA, Takashi HASHIMOTO2003 Volume 65 Issue 4 Pages 370-374
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSWe performed double filtration plasmapheresis (DFPP) 8 times in 6 cases of refractory pemphigus vulgaris, and measured the circulating anti-desmoglein autoantibodies by both immunofluorescence and an enzyme linked immunosorbent assay (ELISA). In 6 DFPP treatments, the skin lesions responded well to this therapy, and the index of either Dsg 1 or Dsg 3 by ELISA decreased accordingly. In 2 DFPP treatments, the patients did not improve, and no reduction of autoantibodies was observed, either. These results indicate that the index of ELISA for Dsg1 and Dsg3 is thus closely correlated to the disease activity in pemphigus vulgaris. ELISA is thus considered to be a very useful test for the accurate measurement of autoantibodies to Dsg1 and Dsg3 in the sera of pemphigus vulgaris.View full abstractDownload PDF (1375K)
Therapy
-
Tetsuya KOGA, Hiroshi TERAO, Masutaka FURUE, Manabu HAMADA, Jyunko NOD ...2003 Volume 65 Issue 4 Pages 375-380
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESS
Dermatologists around the World
-
Tadashi TEZUKA2003 Volume 65 Issue 4 Pages 381-382
Published: August 01, 2003
Released on J-STAGE: May 23, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (1109K)
- |<
- <
- 1
- >
- >|