All issues
Volume 70, Issue 1
Displaying 1-16 of 16 articles from this issue
- |<
- <
- 1
- >
- >|
Color Atlas
-
Yumiko KUBOTA, Juichiro NAKAYAMA2008 Volume 70 Issue 1 Pages 1-2
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (905K)
Mini Review
-
Kentaro KUWAHARA, Toshihiko MASHINO, Hiroo DOHY, Masutaka FURUE, Shini ...2008 Volume 70 Issue 1 Pages 3-7
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (544K)
Clinical Case Reports
-
Yuuichirou AKIYAMA, Fumihide OGAWA, Kazuhiro SHIMIZU, Shinichi SATO, F ...2008 Volume 70 Issue 1 Pages 8-12
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSCase 1: A 62 year-old female. Upon presentation at our hospital, the patient had experienced numbness of both legs for the past 14 months. Erythema and vesicles on the legs had been present for 6 months. She was diagnosed as having Churg-Strauss syndrome based on the presence of bronchial asthma, sinusitis, increased levels of eosinophils and total IgE in peripheral blood, and mononeurititis multiplex. Although the skin lesions and sinusitis improved after oral prednisolone administration, mononeurititis multiplex persisted. Case 2: An 85 year-old female. Intractable bronchial asthma had been present for the 25 years previous to presentation at our hospital. She had occasional hypoesthesia on the lower and upper limbs for which she was not treated. Exacerbation of numbness, edematous erythema, and purpura on the legs and a left foot drop had been observed 18 days before presentation. She was diagnosed as having Churg-Strauss syndrome according to the presence of bronchial asthma, mononeurititis multiplex, eosinophilic pneumonia, peripheral eosinophilia, and pathological findings from the skin lesion. Skin lesions and pneumonia improved after daily oral prednisolone administration. However, the refractory left foot drop was not ameliorated.View full abstractDownload PDF (943K) -
Makiko KAGAYA, Hiroyuki TAKAHASHI, Kouhei SATO, Masanori ITO2008 Volume 70 Issue 1 Pages 13-18
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSWe report a case of familial Henoch-Schönlein purpura (HSP) in three family members. The father developed purpura without any apparent causes, following nephritis. Family history revealed HSP in two daughters, the onset of which occurred 2 years previously in the elder daughter and 4 months previously in the younger daughter. The elder daughter had abdominal symptoms one week prior to the onset of purpura and nephritis approximately one month after development of purpura. Familial HSP has rarely been reported, with only 21 families described in the literature thus far. Although the etiology and mechanisms of HSP remain to be clarified, genetic factors may play an important role in the development of familial HSP. In this report, we review 22 families with familial HSP, including our family, to emphasize the clinical importance of genetic factors in this disorder.View full abstractDownload PDF (818K) -
Sayaka UEKI, Saori TOMIMURA, Yoshikazu MINE, Fumihide OGAWA, Shinichi ...2008 Volume 70 Issue 1 Pages 19-22
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSWe report a 66-year-old female patient of cutaneous polyarteritis nodosa (CPN). The patient had experienced refractory small ulcers on her lower thighs for 30 years. When she visited our hospital, she had suffered from relapsed ulcers of lower thighs for 20 days. A skin biopsy revealed necrotizing vasculitis of small to medium arteries. According to the laboratory and physical examinations, including enhanced CT scan, she was diagnosed as CPN without visceral involvement. Antineutrophilic cytoplasmic antibody was not detected. The ulcers improved after daily oral corticosteroid administration and topical treatment. However, the peripheral circulatory failure caused by insufficient treatments for long time resulted in gangrene on her left fourth toe, leading to its amputation. Although CPN has a better prognosis than polyarteritis nodosa in general, early diagnosis and treatment would be necessary for favorable outcome in CPN.View full abstractDownload PDF (1197K) -
Yoko YOKOYAMA, Fumihide OGAWA, Kazuhiro KOMURA, Emiko TAKEISHI, Shinic ...2008 Volume 70 Issue 1 Pages 23-26
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSWe report a 47-year-old male patient of squamous cell carcinoma (SCC) arising from a lesion of discoid lupus erythematosus (DLE) on the right sole. He worked as a registered surveyor and had to walk for a long time. The erythemas on his both soles and lower lip appeared 10 years ago; then the ulcer on eythema of the right sole had developed 9 months before his visiting our hospital. The skin biopsy from the ulcer showed proliferation of atypical keratinocytes with keratinization and revealed SCC. The tumor was excised with 10 mm margin. The erythemas on other lesions were diagnosed as DLE from the findings of skin biopsy which revealed the liquefaction degeneration of basal cells and lymphocyte infiltration. In this case, SCC is considered to develop from DLE lesion on the right sole. Although sun-exposure plays an important role in inducing SCC on DLE lesion in general, SCC in this case developed in non-sun-exposed area. Chronic inflammation and scars by long walks is considered to be involved in inducing SCC in the DLE lesion in this case.View full abstractDownload PDF (1431K) -
Kae ASAO, Keishi MARUO, Yuichiro YOSHINO, Hazuki KOGUSHI, Taiga MIYAKE ...2008 Volume 70 Issue 1 Pages 27-30
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSA 46-year-old male had itchy erosions and erythema on his head and back beginning in 2002. No mucosal lesion was present, and he was diagnosed as having pemphigus foliaceus. He had anti-Dsg1 antibody dominantly. The skin lesions responded well to oral corticosteroid treatment. In 2005, severe erosions appeared in his oral mucosa, but no skin lesions were present at that time. Histological examination of a mucosal lesion showed acantholysis in the suprabasal layer. Serum was positive for anti-Dsg3 antibody on ELISA. Therefore, he was diagnosed as having pemphigus vulgaris that had transitioned from pemphigus foliaceus. This case was rare because of the transition of a clinical phenotype that coincided with a change in anti-Dsg antibodies.View full abstractDownload PDF (1360K) -
Michifumi KAWAMOTO, Takashi ANAN, Yutaka HATANO, Kazumoto KATAGIRI, Sa ...2008 Volume 70 Issue 1 Pages 31-36
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSA 47-year-old male with a 15-year history of psoriasis presented at our hospital in September 2003 because of rapid aggravation of the eruption accompanied by knee joint pain and a high temperature(38°C). He also had a 2-year history of hypopyon in both eyes, which had been treated by a local ophthalmologist. Physical examination revealed numerous areas of annular erythema on the trunk and upper limbs. Deformation of the nail plates of all fingers and toes was observed. Hyperkeratotic, verrucous plaque was formed on the distal portion of the crura. Histological examination revealed cup-shaped acanthosis with a central parakeratotic column with Munro’s microabscess. Increase in number and dilatation of capillary vessels in the papillary dermis and an increase of collagen fiber in the upper dermis were observed. Laboratory findings showed leukocytosis and elevation of C-reactive protein (CRP). However, neither rheumatoid factor nor HLA-B27 was positive. Ophthalmologic examination revealed bilateral uveitis. X-ray examination showed destruction of the left distal interphalingeal joints and narrowing of the sacroiliac joint. The verrucous lesion gradually improved with combination therapy of topical steroid, zinc oxide ointment and compression with a bandage. Although the eruption on the trunk improved immediately with topical steroid, the eruption on the periphery of limbs and the arthralgia continued. Oral cyclosporine (3 mg/kg/day) improved the arthralgia, intractable eruption and general inflammatory reaction, including leukocytosis and elevation of CRP. However, this therapy was discontinued because of side effects. Oral etretinate, 50 mg daily, was administered instead and resulted in some clinical improvement. However, the eruption recurred in association with worsening of uveitis.View full abstractDownload PDF (1382K) -
Atsushi HOSOKAWA, Kiyohito TAIRA, Yu-ichi YAMAMOTO, Hiroshi UEZATO2008 Volume 70 Issue 1 Pages 37-42
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSWe present a case of alopecia universalis in a 50-year-old woman. Initially, alopecia areata appeared on the head followed by extension over the entire body. The abdominal symptom of “oketsu” was easily seen, which was one of the essential symptoms indicating the need for a Chinese traditional herbal (Kampo) medicine. As for treatment, keishi-bukuryougan, a representative formulation for the symptom of “oketsu”, was tried. After two weeks of treatment, normal hair began to grow and the tender lesions on the abdomen were greatly improved. Hair loss on the entire body stopped, and the disease resolved in about 6 months. When we encounter a case of alopecia universalis of unknown etiology in terms of Western medicine, Kampo medicine could be an effective therapeutic agent if there are typical symptoms indicating the need for Kampo medicine.View full abstractDownload PDF (1437K) -
Akiko OHTSUKI, Nobuyasu MAYUZUMI, Shigaku IKEDA2008 Volume 70 Issue 1 Pages 43-45
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSA 53-year-old man suffered violaceous erythema on his head and neck since July 2004. These skin lesions were gradually expanded to his entire body. At the same time, femoral muscle weakness appeared. The diagnosis of dermatomyositis (DM) was made according to the result of blood test and electromyogram. Chest computed tomography scan revealed anterior mediastinal tumor, and it was diagnosed as a thymoma by the needle biopsy. Surgical resection and chemotherapy was performed. As the result, the improvement of DM was obtained. After that, skin metastasis of thymoma appeared in May 2005 without recurrence of DM. Careful observation and medical treatment are required of the same case.View full abstractDownload PDF (738K) -
Takeshi ISHIGAMI, Naruhiko SAWADA, Muneo NAKAMURA2008 Volume 70 Issue 1 Pages 46-49
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSA 58-year-old woman had undergone augmentation mammoplasty with saline-filled implants 10 years prior to presentation at our dermatology clinic. She had exanthema on the right nipple, which had been diagnosed as herpes simplex at a dermatology clinic in September 2003. Because the lesion was slowly enlarging, she consulted our dermatology clinic in August 2006. Physical examination revealed a 32×28 mm granulomatous erythematous tumor surrounding the right nipple and areola complex. The border was well demarcated. Examination of a skin biopsy specimen revealed intraepidermal acantholysis and large neoplastic cells with light cytoplasm. Mammography showed microcalcification. We suspected Paget’s disease. The patient underwent mastectomy with surgical sentinel lymph node biopsy of the right axilla. Histological examination of surgically resected tissue demonstrated both intraepidermal and noninvasive ductal Paget’s cells. A diagnosis of mammary Paget’s disease was made according to the classification of The Japanese Breast Cancer Society (2004). Although reports of breast cancer after augmentation mammoplasty with silicone or paraffin injection are often seen in the Japanese literature, it is generally considered that a bag prosthesis does not cause cancer. We considered that there was little relation between augmentation mammoplasty and Paget’s disease in our case.View full abstractDownload PDF (964K) -
Hidezumi KIKUCHI, Katsumi OGATA, Mitsuru SETOYAMA2008 Volume 70 Issue 1 Pages 50-54
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSA 47-year-old Japanese man presented with joint pain in the right shoulder and an erythematous lesion associated with a sinus tract on his right axilla. The right shoulder pain had been present for about 8 years. The cutaneous lesion had an approximate 6-month history of slow growth. Examination of a biopsy specimen from this lesion revealed normal epidermis and caseating granuloma composed of centrally located epithelioid cells surrounded by lymphocytes and Langhans giant cells in the dermis, suggesting a diagnosis of scrofuloderma. However, radiography revealed no osseous or pulmonary abnormalities. Results of microscopic examination of the purulent discharge and tissue smears for acid-fast bacilli were negative. Microbiological cultures for bacteria, fungi, and acid-fast bacilli using egg-based Ogawa medium were all negative. The first polymerase chain reaction (PCR) failed to detect acid-fast bacilli. Culture of the purulent materials using MGIT (Mycobacterium growth indicator tube, Becton-Dickinson) was positive. Amplicor-PCR of DNA extracted from the colonies successfully detected the genome specific for Mycobacterium tuberculosis. A final diagnosis of scrofuloderma was made based the findings described above. We here report this case because scrofulderma on the axilla arising from a tuberculous shoulder joint is very rare.View full abstractDownload PDF (1091K)
Review
-
—The Mechanisms and its Mediators—Sakuhei FUJIWARA2008 Volume 70 Issue 1 Pages 55-66
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (784K)
Statistics
-
Takashi UENO, Shinichiro TAKEZAKI, Yuriko MIURA, Seiji KAWANA2008 Volume 70 Issue 1 Pages 67-70
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSThirty-eight patients presented with diabetic foot gangrene during past ten years. The ratio of males to females was about 2.8:1 and their mean age was 63.2 years. Many of them had long histories of poorly-controlled diabetes. The frequencies of diabetic complications were high, including retinopathy (74%), neuropathy (68%), nephropathy (58%), and arteriosclerosis obliterans (18%). Nine cases developed secondarily from tylosis and clavus, most of which had been ill-treated by themselves. The patients were treated conservatively (89%) or surgically (11%). Amputation distal to the tarsometatarsal joint was performed in all the surgical cases. Conservative treatment was effective in most of the cases when bones and joints were not involved.View full abstractDownload PDF (381K)
Therapy
-
Nobukazu HAYASHI, Makoto KAWASHIMA, Mutsumi TSUMURA, Yasuhiro YOSHIDA2008 Volume 70 Issue 1 Pages 71-74
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSNeedle-shaped maltose, which is established by nano-technology, is an innovated instrument for new transepidermal drug delivery system (DDS). Chemicals, which are soluble in maltose, can be transferred physically into the epidermis through the stratum corneum by needle shaped maltose. In this study, we used 5% L-ascorbyl-2-phosphate magnesium (APM) maltose for senile freckles of 4 patients and post inflammatory pigmentation of one patient. This instrument was pressed on the pigmentary lesions of the patients once a week for two month and the change of pigmentation was evaluated. The results showed that three cases were “markedly effective” and 2 cases were “moderately effective”. Slight erythema and swelling were observed in three cases during the test period, but all symptoms disappeared within three days. In conclusion, our results suggested that APM was effective for hyperpigmentation on the face, and needle-shaped maltose was a useful method of trans-epidermal DDS.View full abstractDownload PDF (729K)
Dermatologists around the World
-
Tokio NAKADA2008 Volume 70 Issue 1 Pages 87-88
Published: February 01, 2008
Released on J-STAGE: April 16, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (203K)
- |<
- <
- 1
- >
- >|