Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 101, Issue 11
Displaying 1-11 of 11 articles from this issue
Review article
Monthly report; Progress in Gastroenterology & Hepatology
The present situation in nonalcoholic steatohepatitis (NASH)
Original article
  • Atsunaga KATO, Hideaki KATO, Noboru HIRASHIMA, Tomoyuki SAKAMOTO, Haru ...
    Article type: Others
    Subject area: Others
    2004 Volume 101 Issue 11 Pages 1209-1216
    Published: 2004
    Released on J-STAGE: May 13, 2005
    JOURNAL FREE ACCESS
    The relationship between Helicobacter pylori (H. pylori) and gastric diseases (e.g. peptic ulcer, MALT lymphoma, and stomach cancer) has been widely accepted. Recent studies have also suggested an association between H. pylori infection and idiopathic thrombocytopenic purpura (ITP). In this study, an H. pylori eradication treatment was administered to 20 ITP patients and elucidated for its effectiveness. Among those 20 patients, H. pylori infection was confirmed in 17 (85%) through a C14 urea breath test, a rapid urease test, or a culture examination of a biopsied sample obtained by gastrointestinal endoscopy. Although the other 3 were negative to H. pylori, the H. pylori eradication treatment was also attempted because no other effective treatments had been established at the time of this study. In the H. pylori eradication treatment, lansoprazole (LPZ) 60mg bid, amoxicillin (AMPC) 1500mg bid, and clarithromycin (CAM) 400mg bid were given to each patient for 7 days. For 4 cases, CAM was replaced with metronidazole (MNZ) 750mg bid. The patients whose H. pylori infection was not eradicated after the first treatment received the re-eradication treatment with LPZ 60mg bid, AMPC 1500mg bid, and MNZ 750mg bid for 7 days. After the treatments, the success of eradicating H. pylori was confirmed in all 17 H. pylori positive patients. In addition, platelet recovery was obtained in 11/20 patients (55%), which included 2 H. pylori negative patients and 2 patients whose H. pylori eradication was not successful after the first treatment. No relationship was found between the eradication effectiveness and the following clinical parameters : age, gender, previous therapies, disease duration, presence of anti-nucleus antibody, endoscopic atrophic change in the stomach, or kinds of antibiotics used for the treatment. These results support the efficacy of an H. pylori eradication treatment for ITP patients. A noteworthy result of this study was that an increase of platelet count was observed not only in H. pylori positive ITP patients, but also in 2 out of 3 H. pylori negative ITP patients after H. pylori eradication. Further studies are required to elucidate the efficacy of H. pylori eradication therapy in the patients negative for H. pylori.
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