Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 101 , Issue 5
Showing 1-9 articles out of 9 articles from the selected issue
Review article
Monthly report; Progress in Gastroenterology & Hepatology
Early colorectal carcinomas - Recent progress of diagnosis and treatment
Original article
  • Tomoki FURUYA, Takehiko SOENO, Masafumi KOMATSU
    Type: Others
    Subject area: Others
    2004 Volume 101 Issue 5 Pages 502-509
    Published: 2004
    Released: May 13, 2005
    Although bacterial translocation (BT) is thought to be a main cause of secondary pancreatic infection, the clinical significance is still unclear. Therefore, we investigated relationship between pancreatic infection and BT, analyzing the results of treatments such as continuous regional arterial infusion of protease inhibitor and antibiotics (CRAI), selective digestive decontamination, and early enteral nutrition (SDD/EN) in 45 severe acute pancreatitis patients. The infection rate of 17 cases without CRAI, SDD/EN was 58.8%, and mortality was 23.5%. Antibiotics-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) was often proven in infected pancreatic tissue. Whereas, in 16 cases who underwent both therapy, only one patient died of multi-organ failure (6.3%). Pseudomonas aeruginosa and K. pneumoniae were proven from his feces before pancreatic infection coincidence, and, in autopsy, these bacteria and MRSA were proved from necrotic pancreatic tissue. BT must be large cause of secondary pancreas infection, because CRAI and SDD/EN prevent secondary pancreatic infection. But we must consider other infection routes, and development of antibiotics resistant bacteria.
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Case Report