Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 107 , Issue 4
Showing 1-13 articles out of 13 articles from the selected issue
Review article
Monthly report; Progress in the diagnosis and treatment in PPI-resistant NERD
Round-table discussion; Progress in the diagnosis and treatment in PPI-resistant NERD
Original article
  • Shuichi OHARA, Ken HARUMA, Yoshikazu KINOSHITA, Motoyasu KUSANO
    2010 Volume 107 Issue 4 Pages 588-597
    Published: 2010
    Released: April 05, 2010
    JOURNALS FREE ACCESS
    To evaluate the efficacy of lafutidine (20mg) , famotidine (40mg) and placebo in patients with mild reflux esophagitis (Grades A and B according to the Los Angeles classification) , a double-blind, multicenter, randomized clinical trial was performed for the first time in Japanese patients. In addition to each physician's evaluation, efficacy was evaluated by judging panels using images submitted by each physician. The healing rate after 8 weeks for lafutidine, famotidine and placebo were 67.7%, 56.6% and 41.2%, respectively. Lafutidine was significantly more effective than placebo (p=0.002, according to the judging panels) .
    Based on the evaluation of endoscopic images by the judging panels, 91 (27.1%) of 336 images submitted by each physician were judged to not be mucosal breaks. Judging panels are considered one of the ways to resolve the problem of the need to unify the criteria.
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