Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 108, Issue 1
Displaying 1-13 of 13 articles from this issue
Review article
Monthly report; Targeting molecular therapy for gastrointestinal malignant tumors
Round-table discussion; Targeting molecular therapy for gastrointestinal malignant tumors
Case report
  • Toshiyuki SAKATA, Makoto NARITA, Norito OHTANI, Naoto MIZOGUCHI, Takas ...
    2011 Volume 108 Issue 1 Pages 50-58
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    A 63-year-old woman was admitted with high fever. Laboratory tests showed leukocytosis and elevated C-reactive protein (CRP) levels. Abdominal ultrasonography and computed tomography revealed multiple liver and splenic tumors. We diagnosed phlegmonous gastritis with multiple liver and splenic abscesses based on a discharge of pus from the gastric ulcer on biopsy obtained during esophagogastroduodenoscopy. She showed remission after spontaneous drainage and treatment with antibiotics. A search of the literature yielded no other cases of phlegmonous gastritis with multiple liver and splenic abscesses, and we therefore report this case.
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  • Shozo SASAKI, Nobuhiko UEDA, Tatsuo NAKANO, Masaaki URADE
    2011 Volume 108 Issue 1 Pages 59-67
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    A 61-year-old man was hospitalized for treatment of portal and superior mesenteric venous thrombosis (PSMVT). We selected interventional radiology (IVR) because there were no signs of intestinal necrosis. The thrombosis was significantly reduced and the patient made progress after we performed thrombectomy via catheter aspiration, and thrombolytic therapy via both the superior mesenteric artery and vein. Even if there are no signs of intestinal necrosis, treatment which prevents intestinal necrosis is vital. In the present case, single-stage IVR therapy via both the superior mesenteric artery and vein improved the therapeutic outcome of PSMVT.
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  • Shinya SUGIMOTO, Masazumi TAKAHASHI, Kazuya NAKAGAWA, Taichi YABUNO, F ...
    2011 Volume 108 Issue 1 Pages 68-73
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    A 67-year-old man with von Recklinghausen disease (VRD) was found to have an ill-defined large mass in the ileocecal area on abdominal computed tomography when he was examined for abdominal pain in the right lower quadrant. Because of high serum C-reactive protein level and leukocytosis appendiceal tumor complicated by appendicitis was diagnosed. Due to the possibility of malignancy, standard cancer surgery was carried out to remove the mass, i.e., ileocecal resection together with dissection of the regional lymph nodes. The cecum was displaced by a remarkably enlarged appendix with a firm and thickened wall. The distal portion of the appendix was cystically dilated, forming an abscess. The pathological diagnosis was neurofibromatosis with mucus hyperplasia and abscess formation in the appendix. Neurofibroma of the appendix is very rare, even in patients with VRD. Although it is benign, prompt resection is recommended because of a high risk of appendicitis and malignant transformation.
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  • Masashi YOSHIMITSU, Nobuaki HAYASHI, Yoshibumi KANEKO, Hisashi DOYAMA
    2011 Volume 108 Issue 1 Pages 74-79
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    We report a 28-year-old woman with O157 enterohemorrhagic colitis-associated hemolytic uremic syndrome in whom seizures and transient hemiparesis developed on the 12th day after admission to hospital. Her subsequent recovery was characterized by improvements in renal function and platelet count. The patient recovered after treatment with steroid pulse and plasma exchange therapy, without any sequelae. As there have been few reports on the onset of encephalopathy in adults, we report this interesting case, with reference to the literature for possible effective treatment.
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  • Hirokazu SHOJI, Michio KUROKI, Eriko NAKANO, Keiichiro HIRAMOTO, Yoshi ...
    2011 Volume 108 Issue 1 Pages 80-87
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    We report a duodenal gastrinoma in a 50-year-old man who was admitted to our hospital with tarry stools. Esophagogastroduodenoscopy revealed multiple ulcers in the duodenal bulb and a submucosal tumor in the descending duodenum. His serum gastrin level was 1400pg/ml. We suspected Zollinger-Ellison syndrome and performed selective arterial calcium injection to locate the gastrinoma. Increase in the hepatic venous gastrin level was seen only in the gastroduodenal artery area. We diagnosed a gastrinoma located in the pancreaticoduodenal area. Genetic examination showed a single-base deletion in the MEN-1 gene. At operation, the tumor was found in the submucosal layer of the descending duodenum and was extirpated. He is alive without recurrence 3 years after surgery.
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  • Koichi SATO, You KOJIMA, Yusuke MATSUNO, Yuji WATANABE
    2011 Volume 108 Issue 1 Pages 88-94
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    An 82-year-old man visited a medical clinic for dyschezia. His serum carcinoembryonic antigen (CEA) level was 16ng/ml. Abdominal computed tomography (CT) revealed an 8×7cm tumor in the sigmoid colon. Endoscopy showed that the sigmoid colon was insufficiently dilated but no mucosal lesions were present. Histological examination of biopsy specimens did not show malignant cells. Sigmoidectomy was performed due to suspected submucosal tumor. The final pathological diagnosis was mucoid carcinoma with features of a submucosal tumor which had no mucosal lesions. Mucoid carcinoma with features of a submucosal tumor in the colorectum is rare. Most cases are associated with ulcer lesions or scar lesions on the mucosal surface of tumor because it arises from epithelial cells.
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  • Hirotsugu INABA, Noriyoshi KANAZAWA, Isao WADA, Kazuo YONEYAMA, Tomoo ...
    2011 Volume 108 Issue 1 Pages 95-102
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    The patient was a terminally ill 80-year-old man with multiple lung metastases from hepatocellular carcinoma, that had developed following hepatitis-C virus-associated cirrhosis. He was admitted to our hospital with gingival bleeding, and we diagnosed gingival metastasis from hepatocellular carcinoma, based on histological examination. The bleeding could not be controlled, and the patient became dyspneic. After transcatheter arterial embolization, his bleeding was successfully controlled until his death due to respiratory failure. Transcatheter arterial embolization was a safe and effective treatment in our case.
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  • Ikumi UMEDA, Tsuyoshi HAYASHI, Hirotoshi ISHIWATARI, Makoto YOSHIDA, K ...
    2011 Volume 108 Issue 1 Pages 103-110
    Published: 2011
    Released on J-STAGE: January 05, 2011
    JOURNAL FREE ACCESS
    A 49-year-old man presented with chest pain and was given a diagnosis of aortic dissection based on computed tomography (CT) findings. Two days later the dissection reached the origin of the celiac artery and there was poor blood flow from the body to the tail of the pancreas and fundus of the stomach wall. Severe acute pancreatitis developed. Endoscopy showed a near-circumferential gastric ulcer in the gastric cardia and we diagnosed ischemic gastropathy. A fistula between the area of infected pancreatic necrosis and the stomach had formed spontaneously and the necrotic tissue was draining into the stomach. His recovery was uneventful.
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