Sixty-nine subjects consisting of 9 acute hepatitis, 27 chronic hepatitis, 10 precirrhosis ofliver, 14 liver dirrhosis and 9 normal persons were studied by means of ICG test in an attempt tocompare the rate of ICG disappearance from the plasma with the resuts of liver function testand histological findings of the liver tissue.
The disapperance rate was obtained by withdrawing the plasma in 5, 10 and 15 mins.after intravenous administration of 0.5 mg of ICG per kilogram of body weight.
1) The average rates of ICG disappearance from the plasma were found to be 0.183±0.04 in the normal, healthy persons, 0.130±0.024 in acute hepatitis, 0.158±0.046 in chronichepatitis, 0.129±0.029 in precirrhosis of liver, and 0.092±0.03 in liver cirrhosis. In otherwords, the average values among the patients with liver diseases are lower than those in normalpersons, and the ICG disappearance from the plasma decreases in accordance with the serrerityof the disease.
2) In chronic hepatitis group the disappearance rate of plasma ICG also decreased furtheras they progressed from types I and H of our pertoneoscopic classification, which are believedto be in the normal state of hepatic hemodynamcis, to types III and IV, which are consideredto be abnormal state of the liver circulation. Among type I and II of the peritoneoscopic classification, those belonging to type IIA in our histological classification of liver (Glisson's sheathinflammation type) showed somewhat lower values than those belonging to histological classificationtype I (liver parechymal type) and type JIB (Glisson's capsule scar type).
3) Correlations were found between the plasma disappearance rate of ICG and theresults of the following liver function tests; direct bilirubin level, A/G ratio, gamma-globulinlevel, TTT, CCF, ZTT, S-GOT,
198Au colloid accumulation coefficient of liver, and BSI'.Among these the correlation was significant with the probability of less than 1 % in direct bilirubinlevel, gamma-globulin, BSP, and
198Au colloid accumualtion coefficient of liver.
4) In general, there was a significant negative correlation between the plasma disappearancerate of ICG and BSP; however taking chronic hepatitis group alone, the cases showingabnormal BSP level with normal ICG disappearance rate were higher than those withnormal BSP and abnormal rate of plasma ICG disappearance.
5) Significant negative correlations were found between the disappearance rate of ICGand the following histological findings; liver cell degeneration and kupper cell mobilizationespecially with periportal fibrosis.
View full abstract