Lactic dehydrogenase (LDH) is an enzyme which catalyzes the reversible oxidation oflactic to pyruvic acid.
This report deals with a study of clinical significance of Serum Lactic dehydrogenase (LDH) in surgical disorders. LDH activity in serum was measured colorimetrically by themethod of Cabaud and Wroblewski and LDH isozyme pattrens was obtained with a starch gelelectrophoresis technique by the method of Wieme.
The results are summarized as follows:
1) Serum LDH activity increased in gastric cancer and other malignant conditions, especially in liver metastasis.
2) Serum LDH activity was insignificant for diagnosis in the primary condition of thegastric cancer.
3) Operative removal of malignant tumor was not followed by an immediate decreaseof serum LDH activity.
4) Serum LDH activity was increased in hepatoma and markedly in metastatic cancerof the liver.
5) Serum LDH activity was increased highly in recurrence of malignant tumors.
6) In cholelithiasis serum LDH activity increased slightly to moderately with affected liverfunction tests.
7) The isozyme pattern of serum LDH in primary and metatatic carcinoma of the livershowed in marked increase of LDH-I.
8) Marked increase of Serum LDH activity and LDH-I in serum LDH isozyme may leadto the diagnosis of liver metastasis.
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