In recent years, the chemical studies of the mucous polysaccharides have been obtaining excellent results. Applying the gaschromatography to the analysis of saccharides in the clinic, which has not been used so far, I have gained interesting results and succeeded in developing of quality and quantity analysis by means of the gaschromatography after establishing the method on extracting saccharides from a living body. This method will be used in analyzing the neutral saccharides which consist of mucous polysaccharides in the gastric juice, and will be of much help in researching pathophysiological study of the gastric juice. Namely, regardless of kind of diseases, FUCOSE, MANNOSE, GALACTOSE and GLUCOSE as the constituent of the neutral saccharides, were detected. With a result of the study of samling in the fluctuation of the neutral saccharides at 5% ratio of risk, the speciality of diseases was found in FUCOSE and MANNOSE which up to date have not been studied: in stomach - and duodenal ulcer except stomach cancer, a significant reduction in the figure of FUCOSE was noted in comparison with other groups of disease, and in stomach cancer a significant reduction was seen; on the other hand, in the MANNOSE, a significant increase was observed in the groups of disease in contrast to the healthy people. Although in very few examples in the process of treatment of ulcer patients, the tendency of an increase of FUCOSE, GALACTOSE and a reduction of MANNOSE was remarked according to each recovering stage of the disease.
This study was undertaken to examine the exocrine pancreatic function in 54 patients with liver cirrhosis. The pancreatic function tests included were serial determinations of serum amylase, determination of volume, amylase output, maximal bicarbonate concentration of duodenal drainage following secretin, and 131I-triolein test. In 5 patients, the pancreas was examined histologically, and the exocrine pancreatic function and the morphological changes were compared. 1) Hyperamylasemia was in 35% of the patients with liver cirrhosis. No direct relationship could be found between the hyperamylasemia and the exocrine pancreatic dysfunction which was seen in these patients. 2) The abnormal result of the secretin test was found in 56% of the patients. Markedly increased duodenal volume was obserbed in 28% of them. The decreased maximal bicarbonate concentration was most frequently found in these patients. Low maximal bicarbonate concentrations were found in all of three cases associated with interstitial pancreatitis or marked pancreatic fibrosis. Therefore the low bicarbonate concentration in secretin test was considered to be a most reliable index of pancreatic dysfunction in cirrhosis. 3) The abnormal result of the secretin test was found more frequently in the cases with excessive iron and fat deposition in liver cell, decreased tolerance to glucose, and elevated serum iron than the cases without them. Steatorrhoe was present in 32% of the patients. This could be attributed to the portal hypertension rather than to the pancreatic dysfunction.