The changes of the
35S uptake of the gastric wall and of the
35S excretion into the gastric juice were studied by using the experimental ulcer which was induced by clamping and clamping-cortisone methods in rats.
Furthermore, the effects of different steroidal hormones and non-steroidal anti-inflammatory drugs on the
35S uptake of the gastric wall with ulcer were also studied.
The results of these studies are summarized as follows:
1) The
35S uptake of the gastric wall and the
35S excretion rate into the gastric juice increased remarkably, in the stomach with ulcer induced by the clamping method (C ulcer) compared with that of the normal stomach. The
35S uptake of the ulcerated portion was especially high.
2) The
35S uptake of the gastric wall increased as progress of ulcer continued and reached a maximum at the 10th ulcer day and thereafter decreased gradually in the C ulcer. These changes had a lineal relationship with an aggravating and healing condition of the ulcer.
3) In the group in which the experimental ulcer was induced by the clamping-cortisone method (C-C ulcer), the
35S uptake of the gastric wall was inhibited remarkably at the 10th ulcer day. Thereafter it increased gradually as progress of the ulcer continued and reached a maximum at the 35th ulcer day. It was obvious that the
35S uptake of the gastric wall in this group did not increase so rapidly compared with that in the ulcer.
A lineal relationship was observed between the degree of the
35S uptake of the gastric wall and the rate of healing which was measured by histological examination.
4) At the 7th ulcer day, the inhibiting degree of the
35S uptake of the gastric wall was compared in some groups treated with diff erent kinds of glucocorticoid preparations.
In two groups treated with cortisone acetate and prednisolone acetate, a clear dose-response curve was observed. However, in the groups treated with phosphate compounds, such a clear dose-response was not found. The group treated orally with prednisolone powder showed the same effect as the group treated intramuscularly.
5) The
35S uptake of the gastric wall was inhibited in both groups treated with acetyl-salicylic acid and bucolom, but it was not inhibited in either group treated with indomethacin and phenylbutazone.
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