Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 68, Issue 1
Displaying 1-5 of 5 articles from this issue
  • [in Japanese]
    1971 Volume 68 Issue 1 Pages 1-2
    Published: 1971
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Yasuhiro Yumoto, Tuneo Namba
    1971 Volume 68 Issue 1 Pages 3-15
    Published: 1971
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The scintillation camera is employed for dynamic liver function studies with 131I labelled BSP. This technique provides a unique timed anatomic record of the rate and magnitude of excretion of labelled dye, and the study indicates it to be of significant value in the differentiation of jaundice.
    The subjects comprised 66 cases of various liver diseases including 5 cases of acute hepatitis, 18 cases of chronic hepatitis, 20 of livercirrhosis, 2 of fatty liver, 4 of Dubin Johnson's syndrom, 2 of Gilbert's disease, 2 of complete obstructive jaundice, 2 of incomplete obstructive jaundice and 10 of normal subjects.
    By assuming a three compartments model, kinetic analysis of 131I-BSP distributions in various organs were calculated based upon the disappearance curve of 131I-BSP radioactivity in the serum, time dependent curve of radioactivity over the liver and urinary excretion of 131I-BSP in attempts to clarify the kinetic distribution of 131I-BSP and the time dependent pool size of 131I-BSP in each compartment such as serum pool, liver pool and the other pool.
    The time dependent curves of Q1 (t) which represent the disappearance curve of 131I-BSP from the plasma being decreased more slowly in the early stage in chronic hepatitis, livercirrhosis and obstructive jaundice than in normal subjects. The time dependent size of 131I-BSP pool in the liver, rises more slowly in the cases of acute hepatitis, livercirrhosis and chronic hepatitis than those in normal subjects during initial 30min.
    The time showing the maximum points of the time dependent curve of Q2 (t) is prolonged in the cases of livercirrhosis and obstructive jaundice and also the valves of maximum points are decreased in liver diseases. These facts indicate that the 131I-BSP uptake into the liver is decreased in liver diseases. While the maximum point of time dependent curve of Q2 (t) decrease more markedly in livercirrhosis and acute hepatitis.
    The individual values for the fractional rate constant for distribution and metabolism of 131I-BSP are expressed as k01, k02, k12, k13, k21, k23, k31, and k13. In controls, the calculated rate constant of k21, expressing the uptake from the plasma to liver, is (7.08±1.32)×10-2min-1, k12 is (1.974±0.1301)×10-2min-1 and k02, expressing the excretion from liver into bile duct, is (3.994±1.10)×10-3min-1. The cases of acute hepatitis, liver cirrhosis and obstructive jaundice showed a more remarkable decrease in the values of k21 and k02 than normal subjects.
    In the cases of Dubin Johnson's Syndrom, remarkable decrease (P<0.01) in the values of k02 and billiary excretion of 131I-BSP is showed, but the second rising curve in time dependent curve of 131I-BSP radioactivity in serum is not demonstrated.
    If the ratio of blood 131IBSP value in 30min, divided by the value in 2min. after intravenous injection of 131I-BSP is calculated, the ratio appears to be of significant value in differentiation of the various type of liver diseases.
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  • Susumu Sakaue
    1971 Volume 68 Issue 1 Pages 16-26
    Published: 1971
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Since the measurement of serum immunoglobulin levels has important values for the various liver diseases, its detail is not well understood. The purposes of this report are to describe serum IgG, IgA and IgM levels in patients with acute hepatitis, chronic hepatitis, liver cirrhosis, fatty liver and obstructive jaundice, and to analyse the changes of serum immunoglobulin levels during the treatment with prednisolone in patients with chronic active hepatitis.
    Results are as follows:
    1) Serum immunoglobulin levels have important values for diagnosis and prognosis of the various liver diseases, especially the most important of them is IgM.
    2) Serum immunoglobulin levels are able to be the good target for the plan of therapy with adrenocortical hormones in the patients with chronic active hepatitis, including initial daily dose, maintenance dose and duration.
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  • R. Mizumoto, H. Kuratsuka, K. Kira, I. Honjo
    1971 Volume 68 Issue 1 Pages 27-36
    Published: 1971
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The pancreatic duct of rabbit is lined by columnar epithelial cells which are covered by a thin layer stained well with alcian blue but poorly with periodic acid Schifr stain, and there are goblet cells, stained similar to the thin layer, present between epithelial cells.
    I. Forty-eight hours after infusion of the following agents into the pancreatic duct and the parenchyma were observed.
    1) After infusion of β-glucuronidase, the thin layer and goblet cells disappeared and epithelial lining became uneven in some pancreatic ducts of medium size, and the parenchyma remained almost intact.
    2) After infusion of bile or trypsin, the pancreatic duct remained intact, although a mild edema and hyperemia appeared in the parenchyma.
    3) After infusion of a mixture of bile and β-glucuronidase, the thin layer and goblet cells disappeared, and epithelial lining of the pancreatic duct became uneven and it was broken in some parts, with severe necrotic pancreatitis.
    4) After infusion of a mixture of trypsin and β-glucuronidase, the thin layer, goblet cells and epithelial lining of the pancreatic duct were almost intanct, except some pancreatic ducts of medium size, but the parenchyma showed severe necrotic pancreatitis.
    5) After infusion of phospholipase A, there was a mild depletion of the thin layer and goblet cells, and epithelial lining of the pancreatic duct became uneven, being accompanied with round cell infiltration and hyperemia in the pancreatic parenchyma without necrosis.
    II. A marked fibrosis and round cell infiltration appeared in the pancreas 1 week after infusion of a mixture of bile and β-glucoronidase or a mixture of trypsin and β-glucuronidase.
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  • Giro Sasaki
    1971 Volume 68 Issue 1 Pages 37-49
    Published: 1971
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Diarrhea with milk intake, that is milk intolerance, is not infrequently seen in Japanese adults. A large majority of milk intolerance is today considered as lactose intolerance.
    Various clinical and animal experiments as listed below were carried out to study the pathogenesis of milk intolerance;
    1) Questionaire of milk intolerance to general populations
    2) Lactose tolerance test (LTT)
    3) Light microscopic and electron microscopic study of human jejunal mucosa by biopsy
    4) Assay of disaccharidase activity of the mucosa
    5) Animal experiments with Wister rats-a) the change of intestinal disaccharidase activity after birth, b) lactose load feeding both in quantity and age differences, c) influence of lactase addition to the feed upon the diarrhea in lactose load feeding
    6) Study of maximal blood sugar rise in LTT before and after milk loading in student nurses.
    From all the above experiments the followings were concluded. In Japanese adults lactase activity in the jejunal mucosa is significantly low in comparison with that in the people of the U.S.A. and European countries. This low level of activity is mainly due to a low amount of lactose intake in their daily diet.
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