Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 70, Issue 8
Displaying 1-6 of 6 articles from this issue
  • Takao SHIMOTORI
    1973 Volume 70 Issue 8 Pages 783-791
    Published: 1973
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    For the clinical examination of the achalasia, X-ray type, the largest diameter, longitudinal axis, tension of wall, motility at the esophagus, esophagitis were discussed roentgenologically in detail.
    Thirty cases of the conservatively treated achalasia were successively followed up roentgenologically. Among them, 10 cases (33.3%) had changes of roentgenological types, of which 7 cases changed from spindle type to flask type, 2 cases from flask type to sigmoid type, 1 case from spindle type to flask type, and further to sigmoid type, and 15 cases (50%) had enlargement of the largest diameter of esophagus, as principal roentgenological changes.
    As secondary roentgenological changes, 7 cases (23.3%) had changes of longitudinal axis, 15 cases (50%) had changes of tension of wall, 12 cases (40%) had changes of motility at the esophagus and 14 cases (46.7%) had worsened esophagitis.
    These secondary changes were observed, in general, together with the two principal changes mentioned.
    In examination to the duration of suffering and two principal roentgenological changes, 3 cases (37.5%) had changes of types or the largest diameter of the esophagus among 8 cases which were under 5 years of suffering, 5 cases (45.4%) had changes among 11 cases from 6 to 9 years of suffering, and 7 cases (63.6%) had changes among 11 cases over 10 years of suffering.
    In general, roentgenological changes were in accordance with the duration of suffering.
    In the meanwhile, we used various operative methods in the surgical therapy to this disease. In persuit of the results of operation on 160 cases, 139 cases (86.9%) had good or better results.
    In conclusion, this disease must be strictly followed up roentgenologically. In cases of finding progress of roentgenological abnormalities, surgical therapy must be applied to this disease.
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  • Takao TSURU
    1973 Volume 70 Issue 8 Pages 792-811
    Published: 1973
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Pancreozymin-secretin tests have been performed on 117 patients with various biliary tract diseases prior to surgery and have repeatedly been performed on 33 patients with exocrine pancreatic dysfunction during their postoperative courses. Histological examination has also been carried out on biopsy specimens of pancreas obtained from 50 patients.
    Biliary tract disease is accompanied by exocrine pancreatic dysfunction in 55.5 per cent of the patients. The exocrine pancreatic dysfunction may persist in 18.6 per cent of the patients (10.3 per cent of the 117 patients) until their third postoperative year. The pancreatic disorder was chronic pancreatitis pathologically in 4.27 per cent and was functionally in another 4.27 per cent of the 117 patients.
    Since postoperative chronic pancreatic disorders may give rise to obscure abdominal distress such as dull abdominal pain and digestive disorders, it is assumed that this may be one of the factors which may cause poor end-results in biliary tract surgery. This was found in 1.71 to 4.52 per cent of the 117 patients and may play an etiological role in 10 to 26 per cent of patients with postcholecystectomy syndrome.
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  • (II) Three dimentional observation of the mucosal surface
    Ken-ichi KATSU
    1973 Volume 70 Issue 8 Pages 812-819
    Published: 1973
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    This report deals with three dimentional observation of the gastrointestinal mucosal surface.
    Method: The samples taken from the gastrointestinal mucosal surface and were washed with dimethylpolisiloxane solution and EDTA. and fixed with glutalaldehyde with phosphate buffer, thereafter, those were washed with sucrose phosphate buffer and dehydrated with graded aceton solution. The samples were made the cut surface by a razor, after air drying, the samples were made the deposition of the carbon and gold on specimens. The specimens were examined with JSM-U3 scanning electron microscope.
    Results: The esophagus of rabbits dose not showed the characteristic morphological pattern. But the gastric mucosa showed the gastric pits, gastric glands, surface epithelial cells and the transsectional picture of the surface epithelial cell, on the both surfaces of mucosal surface and cut surface. Duodenum of men and small intestin of rabbits showed the villi, surface epithelial cells, valve of Kerkring and glands, on the both surface. Appendix of rabbits showed the many pore, protrusion of mucosal surface and cripts, on the both surfaces.
    Discussion: Three dimentional examination is very useful methods for comparative study of micro-morphological changes of mucosal surface and histological changes. On the gastrointestinal endoscopic study, this methods will be used to diagnose fine pathological changes; mucosal cancer, chronic inflammation and metaplastic leasion.
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  • Norio HAGA
    1973 Volume 70 Issue 8 Pages 820-834
    Published: 1973
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In order to investigate the relationship between cholelithiasis and chronic pancreatitis, biopsy of the pancreas was performed at laparotomy in 151 cases with cholelithiasis, the pancreatic exocrine function test using secretin was applied in 119 out of them, and histometrical study was made in 56 cases of the 119 cases. Thirty-one cases with gastric lesion were served as controls.
    The disturbance of the pancreatic exocrine function was demonstrated in 30 (25.2%) of the 119 cases: mildly disturbed in 25, moderately in 4, and markedly in one. The group with mildly disturbed exocrine function consists of 8 cases with decreased volume of duodenal aspirate, 12 with decreased maximum bicarbonate concentration and 5 with decreased output of amylase. Of a total of 30 cases with disturbed pancreatic exocrine function, there were 10 cases with decreased volume of the duodenal aspirate, 17 with decreased maximum bicarbonate concentration and 9 with decreased output of amylase. No significant correlation was indicated between the site or type of the gallstones and the result in the secretin test. In the majority of the cases with bacteria in bile, with common bile duct dilatation and with hypercholesterolemia, the disturbance of the pancreatic exocrine function of moderate and marked degree was observed.
    The histometrically determined volume ratio of the pancreatic parenchyma was decreased in the cases with moderately and markedly disturbed pancreatic exocrine function, with the calcium bilirubinate stones, and with the bile duct stones. The volume ratio of the pancreatic parenchyma declined in value of graded fashion corresponding to the age, however, no definite tendency was observed in the cases with cholelithiasis.
    A significant correlation was indicated between the histology of the pancreas and the result of the secretin test in the cases with moderately and markedly disturbed exocrine function. No significant difference was demonstrated between the controls and the group of cholelithiasis in morphological features.
    Only 5 cases (3.3%) of 151 cases with cholelithiasis were regarded as chronic pancreatitis.
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  • Hisao SHIBATA, Yasushi ITO, Hiroshi KASHIMA
    1973 Volume 70 Issue 8 Pages 835-840
    Published: 1973
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Many studies have been done to clarify the cause of hyperbilirubinemia, but still our knowledge concerning the mechanism of the alteration of the tissues by bilirubin is little.
    In the present paper the dyeing capacity of bilirubin to purified collagen and elastin waslinvestigated in vitro.
    Method;
    Serum and phosphate buffer (pH 7.4) were added to collagen or elastin in test tubes, and incubated at 37°C for 30min. After that the collagen or elastin was washed with distilled water repeatedly, and the color of collagen or elastin was observed qualitatively. Quantitatively, after centrifuge of collagen-bilirubin mixture, bilirubin in supernate was measured, and was estimated the amount of collagen bound to bilirubin.
    Results were as follows;
    Collagen was dyed by serum of conjugated hyperbilirubinemia. The amount of dyeing bilirubin correlates with bilirubin concentration in serum. Dyeing bilirubin consists of nonproteinbound bilirubin which is reported in the first report (Jap. J. gastroent. Vol. 69, 673, 1972).
    Collagen was not dyed by serum of unconjugated hyperbilirubinemia but adding of surface active material such as Naphthalene β sulfonic acid, to bilirubin, made possible dyeing of the collagen. The color of collagen was of a different yellow.
    From these results it was concluded that;
    1) Jaundice in conjugated hyperbilirubinemia is due to transportation of nonproteinbound bilirubin through the wall of capillary directly.
    2) To occur the jaundice in unconjugated hyperbilirubinemia, some surface active metarial like substance is needed.
    3) The different yellow color in hemolytic jaundice might be due to the alteration of bilirubin with surface active material.
    4) To clarify the relation between the disappearance of jaundice and the fading of bilirubin bound collagen needs further study.
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1973 Volume 70 Issue 8 Pages 841-848
    Published: 1973
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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