Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 74 , Issue 12
Showing 1-16 articles out of 16 articles from the selected issue
  • Norio SAITO
    1977 Volume 74 Issue 12 Pages 1631-1641
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Results of electron microscopic studies on connective tissue cells in the regenerating mucosa using experimental gastric ulcers are presented.
    At the early ulcer stage, phagocytic cells, especially macrophages mainly developed in the connective tissue which was marginal zone of the ulcer.
    Thereafter, fibroblasts developed and produced collagen fibers and matrix. Proliferation and differentiation of the regenerating mucosal cells occured in this connective tissue. Sometimes, lymphocytes and mesenchymal cells were observed between the regenerating mucous epithelial cells.
    At the late stage, the eosinophiles, plasma cells and macrophages occasionally were observed near the capillaries in the lamina propria of the regenerating mucosa. These cells were kept in contact each other.
    It seems that the connective tissue cells of the stomach achieve the important role of lead cell with the proliferation and differentiation of the regeneratting mucosa.
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  • Mitsugi SUGIYAMA
    1977 Volume 74 Issue 12 Pages 1642-1649
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The transport of endogenous gastrin across the human placenta and the influence of the maternal gastrin to the embryonal development of digestive organs were investigated.
    1. The gastrin levels in the arterial blood of the mother, umbilical arterial and venous blood, were measured by radioimmunoassay immediately after delivery.
    2. Synthetic human gastrin (S.H.G.) was administered successively to pregnant mice. The stomach of the new born was morphologically observed.
    The mean serum gastrin levels were 65.4±11.6 pg/ml in the femoral artery of mothers; 69.0±12.1 pg/ml in the umbilical artery; and 67.5±15.3 pg/ml in the umbilical vein. There were no significant differences among each blood sample.
    The infant's stomach of gastrin administered group was 32.6% heavier in weight, and was 33.3% larger in size, on the average, than that of the control group.
    The results indicate that the maternal gastrin crosses over the placenta freely and accelerates the development of the fetal stomach.
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  • Atsuo NAGATA, Shinichi YOSHIZAWA, Tatsuji HOMMA, Masayuki ODA
    1977 Volume 74 Issue 12 Pages 1650-1659
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Experimental pancreatic injuries were made to investigate the pathogenesis of chronic pancreatitis as follows: 1. incomplete ductal ligation, 2. intraabdominal ethionine administration, 3. low protein feeding, 4. intra-pancreatic Freund's adjuvant injection, 5. chronic ethanol administration. Histological findings of these materials by electron microscopy on acinar and centroacinar regions were compared with those of human chronic pancreatitis. Both of the lesions in acinar cells and centroacinar architectures including acinar lumens appeared to be intricately correlated with the pathogenesis and the development of chronic pancreatitis. In chronic alcoholic pancreatic injuries, the pathological alterations of the latter were dominant.
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  • I. Comparison with HeLa Cells as a Target Cell and Influence of PHA
    Masaharu TSUCHIYA, Toshio MORIZANE, Tetsu WATANABE, Kanji TSUCHIMOTO, ...
    1977 Volume 74 Issue 12 Pages 1660-1668
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The cytotoxicity of peripheral blood lymphocytes from patients with hepatoma against human hepatoma cell line was studied using microcytotoxicity assay. Furthermore, HeLa cell was used as a target cell and the results were compared. The influence of PHA on the cytotoxic activity of the lymphocytes was also studied.
    There was no statistically significant difference between the cytotoxicity of the lymphocytes from patients with hepatoma and from healthy controls against HeLa cells and human hepatoma cell line when the lymphocytes were not stimulated by PHA. The specific cytotoxicity against hepatoma cell line was not observed in patients with hepatoma.
    The cytotoxicity of the lymphocytes cultured with PHA for 72 hours was enhanced both in normal individual and patients with hepatoma, when the target was either HeLa cell or hepatoma cell line. In the hepatoma cases however, PHA-induced cytotoxicity was low compared with that in normal individuals. The difference was statiscally significant.
    The per cent cytotoxicity of the PHA-stimulated lymphocytes was compared with the amount of 3H-thymidine uptake. The ratio of cytotoxicity to 3H-thymidine uptake was higher in patients with hepatoma than normal individuals. The difference was statistically significant. Despite lesser degree of blastogenesis and PHA-induced cytotoxicity against HeLa cells in patients with hepatoma, their cytotoxicity was stronger than that expected from the degree of blastogenesis observed in healthy controls.
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  • Riyuichiro YAMAZAKI
    1977 Volume 74 Issue 12 Pages 1669-1678
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The metabolism of bile acids in patients with cirrhosis is markedly different from that of normal subjects. In addition to altered bile acids pool size, synthesis and turnover rate in patients with cirrhosis, the altered bile acids metabolism might be attributed in part to increased bacterial deconjugation by heavy growth of bacteria in the small intestine. On the basis of the observation, breath-analysis technic was performed after oral administration of 14C-glycine cholate and jejunal fluid was investigated bacteriologically in cirrhotic patients.
    Results: It was noted that the oral administration of Glycine-1-14C cholate when given to patients with bacterial overgrowth in the intestine resulted in increased excretion of 14CO2 in expired air.
    (1) In vivo deconjugation of bile acids was studied with breath analysis technic as well as the culture of intestinal fluid. Three patients groups were studied: Nine normal subjects: 8 with bacterial overgrowth of the small bowel: and 31 with liver cirrhosis.
    (2) The nomal subjects had no appreciable rise in 14CO2 excretion 0.69±0.03 (M±SD) percent administered dose whereas subject with bacterialovergrowth syndromes had rapid appearance of 14CO2 in expired breath 17.25±10.46 (M±SD) percent of administered dose.
    (3) 27 cirrhotic patients had no appreciable rise in 14CO2 in expired air whereas 4 cirrhotic patients (12.9%) had rapid appearance and high output of 14CO2 in expired breath 8.75±3.12 (M±SD) percent of administered dose. In 4 cases with high output of 14CO2 in the breath, all of 2 cases examined bacteriorogically had bacteria with deconjugation ability, that were Lact. bifidus, enterococcus, staph. epidermidis and Eubacterium parvum.
    (4) In the laboratory findings and the clinical status, no significant differences were found between two groups of cirrhotic patients.
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  • Tateki HARA
    1977 Volume 74 Issue 12 Pages 1679-1688
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    It is of interest to clarify whether peripheral lymphocytes in patients with hepatitis were cytotoxic against 51Cr labeled Chang liver cells and what kind of lymphocytes in patients with hepatitis were the most important effector.
    Lymphocytes from all of 4 patients in peak stage with acute hepatitis (AH-peak) and from 9 of 13 patients with chronic active hepatitis (CAH) showed signicantly greater cytotoxicity than normal, but those from only one of 6 patients with chronic persistent hepatitis (CPH) were cytotoxic. In 3 patients with AH-peak and 9 patients with CAH whose lymphocytes were cytotoxic, non-T cell fractions, prepared removal of E-RFC (sheep erithrocyte rosette forming cells), were cytotoxic, but T cell fractions (E-RFC) were not cytotoxic. Furthermore, surface immunoglobulin (sIg) negative “K cell” fractions, obtained through an and-Fab conjugated Sephadex column from non-T cell fractions in 5 patients with CAH, exhibited the greatest cytotoxicity, whereas sIg-bearing B cell fractions were cytotoxic in only one patient.
    Lymphocytes from 6 patients in convalescence with AH, 3 of whom showed greater cytotoxicity at peak stage and were retested in convalescence, were within normal range (comparatively lower 51Cr release than controls), in contrast to persistent cytotoxicity in CAH. This follow-up study suggests that activity of lymphocyte-mediated cytotoxicity is responsible for persistence of the disease and therefore that suppressed activity of “K cells” may lead to recovery from the diseases.
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  • Hitoshi KURATSUKA
    1977 Volume 74 Issue 12 Pages 1689-1698
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Effect of parathyroid hormone on the stomach of male rats of Whister strain was investigated. Administration with parathyroid hormone occured superficial or profound defects of the gastric mucosa in 16.7% of rats and when histamine or dl-ethionine were administered with parathyroid hormone, it caused more frequently, but calcium chloride could not caused any changes in gastric mucosa.
    Parathyroid hormone caused no significant changes in fasting gastric acidity, but significant decrease of hexosamine in gastric mucosa of rats. Administration of histamine or hepatic and pancreatic damage due to dl-ethionine could caused no effect on hexosamine in gastric mucosa.
    It is considerable that gastric erosion caused after administration of parathyroid hormone in rats may be due to decrease of hexosamine as mucosal barrier in gastric mucosa.
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  • Katsutoshi TANIGUCHI
    1977 Volume 74 Issue 12 Pages 1699-1707
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    In order to establish the isotope method of measuring gastric emptying time, basic and clinical studies were carried out, using 99mTc sulfur colloid labelled solid meal and a gamma camera. Both animal and human experiments indicated 99mTc sulfur colloid to be an ideal, stable, nonabsorbable, and safe isotope. Clinically, half gastric emptying time (T 1/2) of GASTROSCINTIGRAM (GSG) was 57±3 min. in 22 normal subjects, 61±5 min. in 10 gastric ulcer patients and 22±9 min. in 5 duodenal ulcer patients without stenosis. Coefficient of correlation of gastrogram in each group was high.
    The new isotpoe method, that is GSG, is simple, accurate, painless, and safe for the patients.
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  • Tomoyoshi KAMIYA, Shigeru YASURAOKA, Fumio OKUNO, Hiromasa ISHII, Masa ...
    1977 Volume 74 Issue 12 Pages 1708-1714
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    To evaluate the angiographic findings in the diagnosis of chronic pancreatitis, selective celiac and superior mesenteric arteriographies (SCA-SSMA) were performed in 29 patients with chronic pancreatitis. In 16 cases out of 29 subjects, the catheter was more carefully introduced to dorsal pancreatic artery and superselective dorsal pancreatic arteriography (SDPA) was done. These angiographic findings were compared with other diagnostic procedures such as endoscopic retrograde cholangiopancreatography (ERCP), oral glucose tolerance test (OGTT) and Pancreozymin-Secretin (P-S) test. With the use of SDPA, caliber irregularity or stenosis of pancreatic artery, hypervascularity in arterial phase and stain in capillary phase were more frequently observed than with SCA-SSMA, especially the stain was observed in 81% of the cases (p<0.05) when compared to 45% with the use of SCA-SSMA. In the cases of more than ten years' duration, hypervascularity and parenchymal stain were no longer observed in SCA-SSMA, and irregularity of surrounding arteries was characteristically encountered. In the cases with marked ductal changes in ERCP, the incidence of caliber irregularity of pancreatic artery and irregularity of surrounding arteries were 50% and 83% respectively, on the other hand, mild-ductal-changed group showed no such findings at all. Concerning the OGTT, the diabetic curves were observed more frequently in the cases which showed hypervascularity and less degree of parenchymal stain. When P-S test was compared with angiography, caliber irregularity of pancreatic artery and parenchymal stain were more frequently seen. In relation to the history of alcohol intake, caliber irregularities of pancreatic and surrounding arteries, andparenchymal stain were more frequently seen in the cases with heavy alcohol intake. Pancreatic arteriography, especially SDPA, is therefore a very useful and superb procedure in the diagnosis of chronic pancreatitis.
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  • Part II Changes of Plasma Glucagon and Insulin Level in Response to Arginine Treatment in Rats with Liver Disorders Induced by CCL4
    Tetsuya OGASAWARA, Akira KIHARA
    1977 Volume 74 Issue 12 Pages 1715-1723
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Pancreatic endocrine function was investigated in rats with liver disorders induced by CCl4treatment.
    The results obtained were as follows:
    1. Basic plasma glucagon level in rats with short-term CC14 treatment showed no significant difference compared with that in the control group, however, the level in rats with chronic liver disorder induced by CCL4 treatment was significantly higher than that in the control.
    Basic plasma insulin level in rats with acute liver disorder induced by CCl4 treatment was significantly higher than that in the control, but no difference was observed between the plasma insulin level in rats with chronic liver disorder induced by CCl4 and that in the control.
    2. There was no significant difference between the plasma glucagon level in response to arginine administration in rats with acute liver disorder induced by CCl4 treatment and that in the control, however, significantly higher responsiveness was observed in rats with chronic liver disorder by CCl4 treatment compared with that in the control.
    On the other hand, a significantly hyper-response of plasma insulin increase to arginine administration was observed in rats with acute liver damage induced by CCl4 treatment and a decrease was observed in an inverse manner in rats with chronic liver damage.
    3. These changes were more pronounced when the levels of plasma insulin and glucagon were estimated by molar ratio (I/G).
    In conclusion, it was conjectured that the abnormalities of pancreatic endocrine function observed in rats subjected to CCl4 treatment were closely related to the pathophysiological conditions of impaired liver cells.
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  • A case diagnosed before initial operation for peptic ulcers and statistical evaluations of the reported cases in Japan
    Hiroshi AKIMOTO, Teruaki AOKI, Yoshimitsu INOMATA, Akiharu SASAKI, Tak ...
    1977 Volume 74 Issue 12 Pages 1724-1734
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • With special reference to direct cholangiography such as ERCP or PTC
    Michihiko SHIMIZU, Susumu KAWAMURA, Tadasu FUJI, Sakae AOYAMA, Katsue ...
    1977 Volume 74 Issue 12 Pages 1735-1742
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    We experienced 24 cases of gallbladder cancer for 7 years, from January 1971 to December 1976, and performed successfully the examination of direct cholangiography such as ERCP or PTC in 14 cases. It proved diagnostic in eleven cases (79%) from their visualized findings preoperatively. Ten cases, in which direct cholangiography such as ERCP or PTC was not performed, could not be diagnosed correctly before operation. Therefore, it is very useful for diagnosis of gallbladder cancer to try direct cholangiography such as ERCP or PTC. However, the resection rate in our cases was very low. That is, although only 4 (17%) out of 24 cases were performed curative operation, almost all cases except one died within one year after operation. In this meaning, early detection of the gallbladder cancer must be done with ERCP, PTC and other procedures.
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  • Method and Clinical Significance in pancreatic cancer
    Ken KIMURA, Takeo YAMANAKA, Kenichi IDO, Hideichi SEKI, Kogorou KASAHA ...
    1977 Volume 74 Issue 12 Pages 1743-1752
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Percutaneous fine-needle aspiration biopsy was performed on seven patients suspected of pancreatic cancer.
    A fine-needle, with an outer diameter 0.6 millimters, was accurately placed in the suspicious lesion of the pancreas under ultrasonic guidance. Six patients had a difinite cytologic diagnosis of pancreatic cancer by this procedure. There were no immediate complications due to the procedure.
    The procedure can be performed easily and safely without any special techniques. Moreover, the repetition of the procedure is safely secured, because of its simplicity and quickness of the method.
    This procedure is of great value to the diagnosis of the pancreas disorders, especially of the pancreatic cancer.
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  • Nobuyuki MIYATANI, Norio SAWABU, Masao YONEDA, Shin NAKAJIMA, Keiichi ...
    1977 Volume 74 Issue 12 Pages 1753-1758
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1977 Volume 74 Issue 12 Pages 1759-1763
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
  • 1977 Volume 74 Issue 12 Pages 1764-1798
    Published: December 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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