Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 74 , Issue 10
Showing 1-17 articles out of 17 articles from the selected issue
  • Eisaku OCHIAI
    1977 Volume 74 Issue 10 Pages 1275-1287
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Thirtyfive cases of deeply infiltrated gastric caneer located in the greater curvature of gastric body were studied to diagnose radiographically the extent of submucosal cancer invasion. These cancer craters including ulcers and mucosal folds were mainly analyzed by comparing the double contrast x-ray finding with the resected stomach and its pathology. The extent of cancer invasion was well correlated with the ratio of the cancer crater to the cancer invasion. According to this ratio, 35 cases were divided into 3 groups and each group showed charactaristic x-ray findings.
    X-ray pictures of mucosal folds overlaying the submucosally invaded area were studied from the following standpoints; the mucosal course abnormality, the change in width of mucosal fold, the smoothness of mucosal surface and the extensibility of mucosal fold. After this study, x-ray findings characteristic to these invasion were obtained.
    As a result of this analysis, the extent of submucosal cancer invasion could be almost perfectly diagnosed by paying attention to these delicate findings.
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  • F. IIDA, I. TEI, K. KOMIYAMA, H. SHIROTA
    1977 Volume 74 Issue 10 Pages 1288-1296
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Scirrhous carcinoma of the stomach was first defined from the histological viewpoint in this paper, and then factors which related to the development of the disease were studied. Since histological type of cancer in the mucosal layer was considered to represent the early phase of cancer, 487 advanced cancers and 40 sm cancers were examined in relation to the development of scirrhous carcinoma. It was clarified that in advanced cancers 78.3% of mucocellular adenocarcinomas and 30.6% of poorly differentiated adenocarcinomas developed into scirrhous carcinoma, but in sm cancers the frequencies of each type above was observed to be higher respectively.
    Statistical study of the depth of cancer infiltration in the gastric wall revealed that the mucocellular carcinomas easily reached the submucosal layer and formed an early feature of scirrhous carcinoma. It was, therefore, presumed that this type of carcinoma remains in the submucosal layer for a relatively long duration and reaches the serosal surface, passing quickly through the tunica muscularis propria. Scirrhous carcinoma showed not only Borrmann 4 but also 3 and 2 sometimes. The determinations of acidity of gastric juice revealed that normal and high acidities were more frequently observed in the cases of Borrmann 2 and 3 and type 3 of early cancer than Borrmann 4 and type 2 c. The acidity of gastric juice may have some influence on the formation of gross findings of stomach cancer. Giant rugal type of scirrhous carcinoma was found in younger generation of female than that of Borrmann 4. Depression of cancer surface was frequently found around the greater curvature of the body of the stomach.
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  • Kiyoshi SHIONO
    1977 Volume 74 Issue 10 Pages 1297-1308
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    We studied the mechanism of gastrin release with insulin-induced hypoglycemia by 7 series of experiments using dogs;(1) normal group, (2) medical vagotomied (M. V.) group, (3) phenoxybenzamine (POB) group, (4) 6-hydroxydopamine (6-OHDA) group, (5) truncal vagotomied (T. V.) group, (6) splanchinectomied (S. P.) group, and (7) truncal vagotomied and splanchinectomied (T. V.+S. P.) group. Each group was composed of 5 dogs.
    We measured serum histamine, serum setotonin, serum norepinephrine, and serum gastrin before and after the intravenous injection of regular insulin every ten minutes for one hour. Serum histamine increased in the normal group and the M.V. group. Serum serotonin changed little in all groups. Serum norepinephrine increased in the normal group, the M. V. group, and the T. V. group, while it decreased in the sympathectomied groups except at the first ten minutes of the POB group. Serum gastrin increased in all groups except the T. V.+S. P. group. It increased remarkably in the normal group and the M. V. group, but there was not much increase in sympathectomied group.
    Thus, I conclude that the mechanism of gastrin release with insulin-induced hypoglycemia is much more affected by the route of posterior hypothalamopituitoadrenal axis than by the anterior hypothalamovagal route. The increase of serum cathecolamine, histamine, and gastrin after the injection of insulin suggests that the final mediator for gastrin release is histamine.
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  • Hiroshi SHIMIZU
    1977 Volume 74 Issue 10 Pages 1309-1322
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    To predict the dumper to the preoperative period, thirty eitgh patients (gastric ulcer: 17, duodenal ulcer: 11, early gastric cancer: 9, advanced gastric cancer: 1) were undergone 150 ml of 50% glucose provocation test at the pre and post operative period. Peripheral venous blood were collected before and 15, 30, 60, and 90 respectedly after the provocation test and then the blood serotonin, histamine and plasma volueme were measured. These patients were also studied by the psychosomatic side using CMI test, TPI test and YG test.
    The results were as follos: 1) Patients judged to be the dumper by preoperative provocation test were 10 patients (26.3%) and half of them (13.2%) became the postoperative dumper.
    2) Negative and suspected dumper by preoperative provocation test did not turn to the postoperative dumper.
    3) Preoperative dumper whose plasma volume decrease more than 15% and whose blood histamine increase more than 20% at 15 minutes after preoperative provocation test, tend to become the postoperative dumper.
    4) As the dumper tend to have psychosomatic characters by RMI test and TPI test, these characted test are useful to predict the dumper at the preoperative preiod.
    5) Patients who have 30% increase of blood serotonin or 20% increase of histamine at 15 minutes of dumping provocation test tend to have postoperative dumping syndrome.
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  • Part I. Fundamental study and the diagnostic value of the test
    Katsuhiko KINUGASA
    1977 Volume 74 Issue 10 Pages 1323-1336
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BTPABA), a new synthetic peptide is specifically hydrolyzed by chymotrypsin to yield p-aminobenzoic acid (PABA), which is estimated colorimetrically by diazotizing.
    The method suitable for assay of chymotrypsin in duodenal aspirates was investigated using BTPABA as a substrate. Then the chymotrypsin output during PS-test was estimated in the patients with pancreatic disorder. The chymotrypsin output significantly correlated to the trypsin output (P<0.001) and to the amylase output (P<0.001). A good correlation was also noted between the chymotrypsin output and the 6 hr-urinary excretion of PABA in PFD (P<0.01).
    These obserbations demonstrate that pancreatic enzymes are secreted in parallel, and pancreatic disease is found to result in parallel decrease in the secretion of chymotrypsin, trypsin and amylase, and that PFD is an accurate diagnostic test of exocrine pancreatic function.
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  • Part II. The correlation of PFD and chymotrypsin output during PS-test
    Katsuhiko KINUGASA
    1977 Volume 74 Issue 10 Pages 1337-1346
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BTPABA), a new synthetic peptide is specifically hydrolyzed by chymotrypsin to yield p-aminobenzoic acid (PABA), which is estimated colorimetrically by diazotizing.
    The method suitable for assay of chymotrypsin in duodenal aspirates was investigated using BTPABA as a substrate. Then the chymotrypsin output during PS-test was estimated in the patients with pancreatic disorder. The chymotrypsin output significantly correlated to the trypsin output (P<0.001) and to the amylase output (P<0.001). A good correlation was also noted between the chymotrypsin output and the 6 hr-urinary excretion of PABA in PFD (P<0.01).
    These obserbations demonstrate that pancreatic enzymes are secreted in parallel, and pancreatic disease is found to result in parallel decrease in the secretion of chymotrypsin, trypsin and amylase, and that PFD is an accurate diagnostic test of exocrine pancreatic function.
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  • Yoshihiro SHIMADA, Kazuhide YAMAMOTO, Humio MUNETOMO, Shiro YUASA, Ken ...
    1977 Volume 74 Issue 10 Pages 1347-1354
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Etiology and pathogenesis of idiopathic portal hypertention were studied in 30 cases of this disease using the technique of peritoneoscopy and liver biopsy, vascular reconstruction studies by serial sections of the biopsy specimens and the detection of Hepatitis B surface antigen and antibody in sera.
    1) The incidence of HBsAg and Ab in these cases was similar to that in chronic hepatitis and HBsAb was detected more frequently that in active cases in chronic hepatitis.
    2) Undulating liver surface was observed by peritoneoscopic examination and obliteration and/or stenotic changes of the terminals of portal vein branches were highly noted by histological reconstruction study.
    3) Above findings suggest that the etiology of the disease is closely related to type B Hepatitis and the changes of portal vein branches are correlated to the pathogenesis of indentation of the liver surface and are important factor to the developement of portal hypertension in the disease.
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  • Ryuichi TAKAYANAGI, Isamu AIZAWA, Shigeo ISSHIKI, Zen ITOH, Takuji NAK ...
    1977 Volume 74 Issue 10 Pages 1355-1361
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    A great number of studies using Heidenhain pouch have been reported but most of them have been concerned with secretory activity. Studies on the motor activity of the pouch are few. In the present study, therefore, long term changes in contractile activity of the Heidenhain pouches were recorded simultaneously with those of the main stomach in conscious dogs by means of chronically implanted force transducers.
    It was found that during the interdigestive state Heidenhain pouches contracted precisely in association with interdigestive contractions in the main stomach. During this time a series of strong contractions lasted for 24.2±1.90 min and then ceased abruptly. Such strong contractions were followed by a long period of motor quiescence lasted for 86.8±6.06 min. These characteristic recurring episodes in the Heidenhain pouch and the main stomach lasted during the interdigestive state but were inhibited by the ingestion of food or i.v. administration of pentagastrin (0.5, 1.0, 2.0 p.g/kg-hr). These findings indicate that the interdigestive motor activity of the stomach is strongly controlled by a humoral factor (s) rather than the parasympathetic nervous system.
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  • Tadao TAKAHASHI, Hisaaki SHIMAZU, Masayoshi TANI, Yo KATO
    1977 Volume 74 Issue 10 Pages 1362-1369
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The gastrin cell (G cell) population in canine gastroduodenal mucosa was studied quantitatively after identifying the cell by immunofluorescence staining technique. The number of G cells per unit mucosal surface, which was considered to be important in the physiology of the endogenous gastrin release, was significanity greater on the greater curvature than in other areas of the pyloric antrum. However, the number per unit mucosal volume was the greatest in the proximal antrum near the antrofundic border, reflecting the relative thinness of the mucosa in this area. As for the total number of G cells, an overwhelming majority was found in the pyloric antrum, being much smaller in the proximal duodenum.
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  • in comparison with chronic pancreatitis
    Hiroshi MAKINO, Norio SAWABU, Masao YONEDA, Shin NAKAJIMA, Kechi SHIMA ...
    1977 Volume 74 Issue 10 Pages 1370-1381
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Comparative diagnostic value of various examination methods of the pancreas was evaluated in 34 cases of pancreatic cancer and 49 cases of chronic pancreatitis. Endoscopic retrograde cholangiopancreatography(ERCP)achieved the highest incidence of abnormal findings and the correct diagnosis compared to the other diagnostic methods.However, some of the chronic pancreatitis were hardly differentiated from pancreatic cancer by ERCP. Therefore, in some cases, combined diagnostic methods were necessary for the diagnosis of pancreatic cancer.
    Pancreatic function tests were not effective for the differential diagnosis of pancreatic cancer. But following findings were rather interesting. In chronic pancreatitis, the output of TCA-precipitable radioactivity was impaired in parallel with the maximal ration of TCAprecipitable radioactivity to total protein. In pancreatic cancer, on the other hand, the latter was fairly well preserved compared to the former. Both disease showed the same incidence of diabetic pattern of 50g GTT. While, in IRI response of 50g GTT, chronic pancreatitis showed very low response and pancreatic cancer showed higher response than normal.
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  • Yoshio HARADA, Hidemi ABIKO, Tadaaki IWATAKE, Kazuhiko KUNISHIGE, Hiro ...
    1977 Volume 74 Issue 10 Pages 1382-1386
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 74 Issue 10 Pages 1387-1391
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Nobuyuki MIYASAKA, Morio OTSUKA, Masataka ITO, Hiroshi OKADA, Masao OK ...
    1977 Volume 74 Issue 10 Pages 1392-1397
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    A 54 year-old female case of primary biliary cirrhosis (PBC) with typical Sjgren's syndrome and sclerodactlyia is described.
    Initial symptom of Raynaud's phenomenon since 10 years before was followed by fluctuating jaundice during recent five years. On admission marked jaundice of obstructive ytpe with elevated serum transaminase, notable increased serum alkaline-phosphatase (603 IU), increased seurm IgM (343mg) and strong positive antimitochondrial antibody was strongly suggestive of PBC. The diagnosis was determined by the histology of wedge-biopsied specimen of the liver. Additionally coexistence of typical Sjgren's syndrome by parotid sialography, lip salivary gland biopsy and Schirmer's test, and of sclerodactylia by finger skin biopsy was confirmed.
    Immunological cross reactivity between the bile duct system and salivary duct system might be considered for the pathogenesis in this case.
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  • Atsuhiko KUSAKABE, Kazuaki YADA, Youichi ARAKAWA, Tomoo SHINODA, Hirot ...
    1977 Volume 74 Issue 10 Pages 1398-1402
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • 1977 Volume 74 Issue 10 Pages 1403-1419
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • 1977 Volume 74 Issue 10 Pages 1420-1431
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • 1977 Volume 74 Issue 10 Pages 1432-1462
    Published: October 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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