Using CIS gastrin radioimmunoassay kit, serum gastrin levels in response to feeding were measured in 50 preoperative patients with gastroduodenal diseases, 8 normal subjects, and 48 postoperative cases.
1) Serum gastrin levels in patients with peptic ulcer were significantly higher than the levels of the normal subjects in 7 minutes after feeding. But, as the fasting or postprandial serum gastrin levels in patients with gastric ulcer were compared in accordance with the location of the lesions, the lesions locating in the parietal cell area tended to show higher gastrin levels than those in the antral area. The serum gastrin levels in patients with gastric cancer showed the same tendency as the patients with gastric ulcer. In case of comparison of the serum gastrin levels in various gastric lesions, the location of the lesions has to be the primary consideration.
2) After selective proximal vagotomy in patients with duodenal ulcer, the fasting or postprandial serum gastrin levels were significantly higher than the preoperative levels. Selective proximal vagotomy augmented the gastrin response to feeding. It will be assumed that this result was in consequence of reduced acid secretion after selective proximal vagotomy.
3) After selective vagotomy and antrectomy in patients with gastric ulcer, the fasting or food-stimulated serum gastrin levels were significantly lower than the preoperative levels. Nevertheless, after total gastrectomy and jejunal interposition in patients with gastric cancer, the serum gastrin levels were increased in response to feeding. From these results, both the antral and duodenal gastrin might be considered to respond to feeding.
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