Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 74 , Issue 5
Showing 1-17 articles out of 17 articles from the selected issue
  • H. L. Bockus
    1977 Volume 74 Issue 5 Pages 541-547
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Yasuhiro MIZOGUCHI, Sumio KUWAMURA, Morikazu ONJI, Masahiro NAKAO, Tak ...
    1977 Volume 74 Issue 5 Pages 548-556
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    When peripheral lymphocytes from patients with drug-induced allergic intrahepatic cholestasis were stimulated with a specific drug in vitro in the presence of liver microsome fraction or soluble liver specific antigen fraction, the production of lymphokines was seen in many cases.
    By the injection of culture supernatant of stimulated lymphocytes into mesentery vein of dogs, cholestasis chiefly in the central zone of lobules was induced in the liver. On the contrary, no cholestasis could be observed in dogs administered the supernatant of lymphocyte culture prepared from normal individuals in the presence of drugs.
    Moreover, only slight swelling of hepatocytes was observed in the liver when normal lymphocytes were stimulated with PHA-P and culture supernatant was injected into the portal vein of dogs.
    These results suggest that the sensitized lymphocytes may produce a factor (or factors) by stimulation with the specific drug-carrier and this factor (or factors) causes cholestasis in the liver.
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  • Shinsuke TERANISHI, Hiroyuki ITAYA
    1977 Volume 74 Issue 5 Pages 557-564
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    In order to clarify the mechanism of exocrine pancreatic secretion, pancreatic secretory response to secretin, pilocarpine, and electrical stimulation of the vagus nerve and the effect of atropine which has been considered to suppress the pancreatic secretion were studied in pancreas of dogs. The rate of secretion, ionic composition, and enzyme output in pancreatic juice were measured and compared.
    The secretion of water and electrolytes was enhanced by secretin. It was not reduced by atropine. Pilocarpine increased pancreatic flow and enzyme output in pancreatic juice. Atropine, however, prevented all changes caused by pilocarpine, implying that the secretion was initiated by acetylcholine. The secretion was induced by electrical stimulation of the vagus nerve was not suppressed by atropine. This evidence suggested that the parasympathetic nerve fibres alone were not purely stimulated and that modifications of other secondary factors were added by electrical stimulation of the vagus nerve.
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  • Part I: Gastric secretory responses with tetragastrin (4γ/kg, i.m.)
    Hiroshi MUTOH
    1977 Volume 74 Issue 5 Pages 565-569
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The gastric secretory responses with tetragastrin were investigated in patients with endoscopically determined stages of gastric ulcer.
    In patients with active ulcer, the gastric secretory responses with tetragastrin were more increased than those at the other stages. These changes of the gastric secretory responses were mostly influenced by changes of the gastric secretory volumes.
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  • Part II: The change of sensitivity to stimulation of gastric secretion during the various stages of gastric ulcer
    Hiroshi MUTOH
    1977 Volume 74 Issue 5 Pages 570-575
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The gastric secretory responses with tetragastrin were investigated in patients with endoscopically determined stages of gastric ulcer.
    The increased sensitivity with the stimulation of tetragastrin during the active stage of ulcer was demonstrated by administration of the graded doses of tetragastrin infusion.
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  • Part III: Vagal influence in gastric secretion during the various stages of gastric ulecr
    Hiroshi MUTOH
    1977 Volume 74 Issue 5 Pages 576-580
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The gastric secretory responses with tetragastrin were investigated in patients with endoscopically determined stages of gastric ulcer.
    1) The increased sensitivity with the stimulation of tetragastrin during the active stage of ulcer was demonstrated by administration of tetragastrin infusion.
    2) “Medical vagotomy” with hyposcine-N-butylbromide was applied during tetragastrin infusion. Followed to the medical vagotomy, acid and pepsin outputs were more decreased at the active stage than those at the other stages. A change in vagal tone during the various stages of gastric ulcer may have contributed to this observed difference in sensitivity.
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  • Saburo NAKAZAWA, Kenji IMAI, Manabu KAJIKAWA, Kenichi YAMADA, Teruyosh ...
    1977 Volume 74 Issue 5 Pages 581-588
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    It is considered that the development of new animal models is essential for the study of early diagnosis and curable treatment of the pancreatic carcinoma. The following experiments were carried out in order to investigate the carcinogenic effect of Diisopropanolnitrosamine (DIPN). DIPN in olive oil was administered subcutaneously once a week to male golden hamsters at 3 dose levels (250, 500 and 1000 mg/kg body weight) and the animals were sacrificed after twenty weeks. In 250 mg group, the hyperplasia of pancreatic ducts of minimal degree was seen, but no neoplastic change was observed. In 500 mg group, tumor nodules were grossly recognized in some cases and papillary hyperplasia of pancreatic duct-cell, ductal adenomas or ductal adenocarcinomas were observed in all cases microscopically. The ductal adenocarcinomas coexisted with adenomas were found in all but one of eight cases. These neoplasms resembled human pancreatic tumors. Outside the pancreas, cholangiocarcinoma and adenoma of the lung were seen in 25% of the cases respectively. The findings in 1000 mg group were similar to 500 mg group. These results suggest that the subcutaneous administration of DIPN is one of the best methods to induce the pancreatic carcinoma experimentally.
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  • Hideo WATANABE, Mahito KINOSHITA, Toshihiko KONDO, Masatoshi KONISHI, ...
    1977 Volume 74 Issue 5 Pages 589-596
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Fourteen mongrel dogs with Heidenhain pouch were subjected to feeding experiments in order to analize the influence of the abdominal vagi (especially the gastric antral branches), the antrum and the duodenum on humoral gastric secretion.
    Group I: After construction of an Heidenhain pouch in eleven dogs, the antral branch of the vagus nerve was cut as the first stage procedure. Then, antrectomy with Billroth I gastroduodenostomy as the second stage operation and transthoracic truncal vagotomy as the third stage surgery were done.
    Group II: After construction of an Heidenhain pouch in three dogs, antrectomy with Billroth II gastrojejunostomy as the first stage procedure, and transthoracic truncal vagotomy as the second stage operation were done.
    The control dogs showed an increased pouch secretion and an elevation of the serum gastrin level after feeding. However, following antral vagotomy, both the pouch secretion and the serum gastrin level after feeding decreased significantly.
    Furthermore, subsequent antrectomy with Billroth I gastroduodenostomy resulted in a further significant decrease in both the pouch secretion and the serum gastrin level. Following antrectomy with Billroth II gastrojejunostomy, both the pouch secretion and the serum gastrin level decreased similarly as in the first group.
    In dogs with transthoracic truncal vagotomy in the above two antrectomized groups, the pouch secretion showed a tendency to increase. While, the serum gastrin level increased slightly in the first group, it was not elevated in the second group.
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  • Toshihiko KOJI
    1977 Volume 74 Issue 5 Pages 597-607
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The cases of liver cirrhosis in Nagasaki district where incidence of liver cirrhosis and primary liver cancer is high were studied with respect to prognosis. The results are summarized as follows:
    1) Follow up of 101 clinical patients revealed rather satisfactory prognosis in many cases. Survival for over 5 years was observed in 41 cases, and 15 among the 18 patients with over 10 years of survival are still living. The maximum survival period was 20 years.
    2) In the examination of 653 autopsy cases during 1946 1974, it was revealed that mortality due to type A cirrhosis (classified by Miyake) and hepatic failure decreased remarkably year after year but on the other hand mortality due to type B cirrhosis, gastrointestinal hemorrhage and other fatal diseases increased. This tendency became more prominent from 1969-1971 and it was likely that cirrhosis alone hardly results in death.
    3) Mortality due to cirrhosis with hepatoma has been increasing while that due to the former without the latter is decreasing. This was verified also by the experience of 4 cases of cirrhosis in which complication by hepatoma developed during the clinical course. It is warned that the complication by hepatoma is an important problem for the prognosis of liver cirrhosis.
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 74 Issue 5 Pages 608-618
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    By using percutaneus transhepatic cholangiography and endoscopic pancreato-cholangiography, preoperatively we have diagnosed 59 cases of cancer of the pancreas and the biliary tract included 15 cases of cancer of the periampullary region.
    In 11 out of 15 cases of cancer of the periampullary region, radical operation was performed, and other cases refused to have it.
    We have investigated on the clinical courses, the diagnostic value of X-ray examination, PTC and ERCP, and otherwise the prognosis of the periampullary cancer.
    We might conclude that PTC and ERCP were most useful examinations for the diagnosis of biliary diseases. Because, the end of common bile duct which dilated in high grade showed characteristically the feature of “U” type obstruction with pressure marks.
    The prognosis of these cases was discussed retrospectively from the view points of macroscopic type and size of the tumor, metastasis to the local lymphnodes, the infiltration of vessels in these lesions at the time of operation, and the term from the onset of symptomes to operation.
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  • Takanori ONO, Masao OHTO, Koichi KAWAMURA, Masahiko MORITA
    1977 Volume 74 Issue 5 Pages 619-633
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Duodenal bile was collected from 28 patients with cholesterol gallstones and 11 control subjects, and analyzed for lipids (bile acid, lecithin and cholesterol), bile acid composition and ratio of glycine-to taurine conjugated bile acids (G/T). Fifteen of the patients with gallstones were treated with a daily dose of 500 mg or 300 mg chenodeoxycholate (CDCA), and their duodenal bile was similarly analyzed for its composition after three months of treatment. Fasting serum bile acid was determined in eight patients treated with CDCA before and at the end of three months' treatment.
    The ratio of bile acid plus lecithin to cholesterol and that of bile acid to cholesterol tended to be lower in patients with cholesterol gallstones. There was no significant difference in bile acid composition and G/T in the bile between patients with cholesterol gallstones and control subjects.
    The ratio of bile acid plus lecithin to cholesterol and that of bile acid to cholesterol were significantly increased by both doses of 500mg and 300mg of CDCA, but the increase was more significant with 500 mg. The proportion of chenodeoxycholic acid in the bile acid composition was increased by CDCA treatment. The ratio of lithocholic acid to total bile acid did not significantly change in the bile after three months of treatment. Between 500mg and 300mg doses there was no significant difference in bile acid composition excluding
    ursodeoxycholic acid after treatment. The values of G/T and fasting serum bile acid were not significantly altered by CDCA treatment.
    These observations suggest that the 500 mg dose for CDCA treatment improves the cholesterol solubilizing capacity of the bile to such an extent as to dissolve cholesterol gallstones in the patient.
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  • Masaji NAMBU, Yooko OIKAWA, Yuuji YAMASHIRO, Norio KOBAYASHI, Toshihik ...
    1977 Volume 74 Issue 5 Pages 634-644
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The functional capacity of the liver was determined in 48 patients with various parenchymal liver diseases and in 19 normal subjects employing kinetics analysis of hepatic removal of indocyanine green (ICG).
    The maximum removal rate (Rmax) was calculated through Lineweaver-Burk regression from submaximal dosis (0.5, 1.0, 3.0, 5.0mg/kg BW) of ICG. This function equalled 3.18 ± 1.62mg/kg/min (mean ± SD) in normal subjects, and it was 0.34 ± 0.11mg/kg/min in liver cirrhosis. Rmax calculated from three loading dosis (0.5, 3.0, 5.0mg/kg BW) was more useful than another three dosis (0.5, 1.0, 5.0mg/kg BW) to differentiate liver diseases from normal.
    Relationship between Rmax calculated by the three point analysis and by two point analysis (0.5 and 5.0mg/kg BW) showed a significant correlation (r=0.8297 p<0.01). This results suggested that Rmax through two point analysis is clinically useful.
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  • Hideki OHKUBO, Hirotaka MUSHA, Kazuro KOTODA, Kunio OKUDA
    1977 Volume 74 Issue 5 Pages 645-654
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    The changes in serum bilirubin levels following intravenous injection of 50 mg of nicotinic acid have been studied in normal subjects and in patients with hepatic disorders.
    The followings are the conclusions:
    1. This test provides information for the differential diagnosis in terms of increment, peak time and retention of unconjugated bilirubin.
    2. Increment of unconjugated bilirubin after this test in patients with Gilbert's syndrome was above 1 mg/ 100 ml, distinctly greater than in patients with unconjugated hyperbilirubinemia unrelated to Gilbert's syndrome.
    3. Evidence is presented that the spleen contributes in a large measure to the increase of unconjugated bilirubin after this test.
    4. For unknown reasons, prednisolone suppressed the increase of unconjugated bilirubin after this test.
    The nicotinic acid test is useful as a tolerance test with endogenous bilirubin, but it should be that the hyperbilinemic curve is consequence of the formation of unconjugated bilirubinin the spleen and its inadequate disposal in the liver.
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  • [in Japanese]
    1977 Volume 74 Issue 5 Pages 655-657
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • 1977 Volume 74 Issue 5 Pages 658-665
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • 1977 Volume 74 Issue 5 Pages 666-676
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • 1977 Volume 74 Issue 5 Pages 677-707
    Published: May 05, 1977
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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