Fourteen mongrel dogs with Heidenhain pouch were subjected to feeding experiments in order to analize the influence of the abdominal vagi (especially the gastric antral branches), the antrum and the duodenum on humoral gastric secretion.
Group I: After construction of an Heidenhain pouch in eleven dogs, the antral branch of the vagus nerve was cut as the first stage procedure. Then, antrectomy with Billroth I gastroduodenostomy as the second stage operation and transthoracic truncal vagotomy as the third stage surgery were done.
Group II: After construction of an Heidenhain pouch in three dogs, antrectomy with Billroth II gastrojejunostomy as the first stage procedure, and transthoracic truncal vagotomy as the second stage operation were done.
The control dogs showed an increased pouch secretion and an elevation of the serum gastrin level after feeding. However, following antral vagotomy, both the pouch secretion and the serum gastrin level after feeding decreased significantly.
Furthermore, subsequent antrectomy with Billroth I gastroduodenostomy resulted in a further significant decrease in both the pouch secretion and the serum gastrin level. Following antrectomy with Billroth II gastrojejunostomy, both the pouch secretion and the serum gastrin level decreased similarly as in the first group.
In dogs with transthoracic truncal vagotomy in the above two antrectomized groups, the pouch secretion showed a tendency to increase. While, the serum gastrin level increased slightly in the first group, it was not elevated in the second group.
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