Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 75, Issue 6
Displaying 1-16 of 16 articles from this issue
  • H. YAMADA, K. KOBAYASHI, E. MITANI
    1978 Volume 75 Issue 6 Pages 789-798
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Gastric and duodenal motility were monitered by means of strain gauge in rabbits anesthetized by ethyl carbamate, and the authors discussed the effects of gastrin, secretin and CCK-PZ on them.
    1) The gastric and duodenal motility were accelerated slightly by the administration of little dose of tetragastrin, and after the administration of large dose the gastric motility was accelerated, while on the patterns of the duodenal motility the certain trend was not observed.
    2) The gastric motility was not effected by the administration of little dose of secretin, and the certain trend on the patterns of the duodenal motility was not observed. While, after the administration of large dose of secretin the gastric motility was accelerated in some cases, but on the patterns of the duodenal motility the certain trend was not observed.
    3) After the administration of little dose of CCK-PZ the gastric motility was not effected, and various patterns of the duodenal motility were observed, while the gastric and duodenal motility were accelerated by the administration of large dose of CCK-PZ.
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  • Part II: Relationship between Gastric Acid Secretion and the Recurrence of Duodenal Ulcer
    Yoshinori TANAKA, Sotaro FUJIMOTO, Kimie FUGITA, Zenji SASAKI, Kunihik ...
    1978 Volume 75 Issue 6 Pages 799-806
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Fifty-seven patients with duodenal ulcer were divided into two groups with endoscopic follow-up study: one is the recurrent groups (35 cases) assuring the recurrence of duodenal ulcer and another is the non-recurrent group (22 cases) not assuring the recurrence of duodenal ulcer. Gastric analysis was examined to all of them in the two different stages (active and healed) under stimulation of AOC-tetragastrin 4γ/kg i.m.
    The results were as follows.
    1) In the active stage BAO of the recurrent group was higher significantly than that of the non-recurrent group but in the healed stage BAO of both groups decreased and there was no significant difference between both groups.
    2) In the active stage MAO of both groups was high and there was no significant difference between both groups but in the healed stage, though MAO of the non-recurrent group clearly decreased, that of the recurrent group was kept in high level.
    3) We would propose [BAO/MAO_??_40%] and [BAO_??_7.5mEg/h] as criteria of the recurrent group and [BAO/MAO_??_15%] as a criterion of the non-recurrent group.
    We concluded that continous high BAO and high MAO in the healed stage were concerned to the recurrence of duodenal ulcer.
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  • Shingo HAYASHI
    1978 Volume 75 Issue 6 Pages 807-817
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Diurnal changes of the circulating gastrin level were followed by assays with the CIS G-RIA kit in 127 patients with diseases of the digestive system (gastric ulcer, scar from gastric ulceration, duodenal ulcer, gastric carcinoma, post gastrectomy, liver disorder, pernicious anemia and abnormal controls). There was no definite trend in diurnal changes of the serum gastrin level by age or sex of patients, nor was there any significant difference by number of lesions developed, localization of lesions or degree of invation between the group of patients with peptic ulceration and that of patients with depressed gastric carcinoma. In both groups, entirely comparable inverse correlationships of serum gastrin level with gastric acidity were noted. Patients with elevated type of gastric carcinoma showed a characteristic hypergastrinemia, suggesting possible involvement of some factor other than the gastric acid. The gastrin secretory response to stimulation by food ingestion was scarcely affected by the gastric acid but related to activity of ulceration; the rate of gastrin secretion was high in acute stage of ulcer as well as in early depressed gastric carcinoma whereas it was low in inactive scar of gastric ulcer and in elevated gastric carcinoma.
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  • Hitoshi ASAKURA, Toshifumi HIBI, Tadashi TANAKA, Soichiro MIURA, Sadak ...
    1978 Volume 75 Issue 6 Pages 818-825
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Therapeutic effect of prednisolon injection directly into the superior and inferior mesenteric arteries in 20 cases of ulcerative colitis at the active stage or acute exacervation was as follows:
    1) Of the 16 patients, 10 (62%) showed improvement by subjective and objective criteria one week after the injection.
    2) Two of 3 patients with toxic megacolon complicating ulcerative colitis were responded very well with this injective treatment.
    3) Cases with the inferior mesenteric arteries, of which diameters were more than 6mm were responded more effectively by the treatment than cases with those arteries, of which diameters were less than 6mm.
    4) It is more effective for cases within the first year after diagnosis of ulcerative colitis and for cases of initial attack than for cases with relapsing-remitting course.
    5) There was no case with any side effects of this treatment in our series.
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  • Takeshi OKANOUE
    1978 Volume 75 Issue 6 Pages 826-837
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In order to elucidate the cells relating to fibrogenesis in liver diseases, an electronmicroscopic study was made in cases of fulminant hepatitis, chronic hepatitis, cirrhosis of liver and experimental liver damages induced by carbon tetrachloride and vitamine A. Some of the fat-storing cells had many of the morphologic features generally associated with collagen formation in fibroblast. They possessed well developed rough endoplasmic reticulum containing a electron-dense flocculent material and well developed Golgi apparatus. It was considered that fiber formation in intralobular area was mainly due to connective tissue synthesis by fat-storing cells in Disse's space. On the other hand, fibrogenesis around the proliferated bile duct was pursued by fibroblast, usual formed. In the area of massive necrosis in fulminant hepatitis, both fat-storing cell and fibroblast were relating to fibrogenesis. In experimental hypervitaminosis A, electron microscopy demonstrated an increase in number of fat-storing cell, whereas remarkable perisinusoidal fibrosis was not observed. These findings suggested that there was no direct relationship between the action of vitamine A storage and the activity of fibrogenesis in fat-storing cell.
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  • Kazuo TARAO, Osamu ENDO, Koi SO, Tamaki MOROI, Takao IKEUCHI, Takashi ...
    1978 Volume 75 Issue 6 Pages 838-844
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The effect of endotoxemia on the specific gravity, concentrations of total protein, albumin and globulin in the ascitic fluid was studied in 42 cirrhotic patients with ascites. The specific gravity in the endotoxemia group in Limulus assay (group A) was significantly larger than that in the nonendotoxemic group (group B) (P<0.01). The protein concentration in group A was significantly higher than that in group B (P<0.01). The albumin concentrations in group A was significantly higher than that in group B (P<0.01). The globulin concentration in group A was significantly higher than that in group B (P<0.01). Ascites-to-serum protein ratio in group A was significantly larger than that in group B (P<0.01). Ascites-to-serum albumin ratio in group A was significantly larger than that in group B (P<0.01). Ascites-to-serum globulin ratio in group A was significantly larger than that in group B (P<0.01). A follow-up study has demonstrated the paralled changes between endotoxemia and concentration of total protein and albumin in the ascitic fluid, and ascites-to-serum ratio in protein, albumin, and globulin in some of those patients.
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  • Toru KASHIWAGI
    1978 Volume 75 Issue 6 Pages 845-855
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Scintiphotosplenoportography (SSP) which permits a clear visualization of portal venous system by injecting radioisotopes such as 99mTc or 133Xe into the spleen and following its course by scintillation camera, has been developed. SSP was performed in 154 instances in 136 patients. No significant complications such as severe pain or splenic hemorrhage were encountered in all patients studied, so that SSP was considered to be a relatively safe procedure. The flow patterns of SSP were classified into 9 groups according to the direction of collateral flow and were studied in various diseases.
    In 38 out of 49 patients with liver cirrhosis (77%), portosystemic collaterals were observed. In 48 patients with chronic hepatitis, 8 patients (17%) have portosystemic collaterals. Hepatopetal collaterals were observed in 3 out of 7 patients with carcinoma of the pancreas. It appears that SSP is also useful for pathophysiological diagnosis of carcinoma of the pancreas. In detecting esophageal varices, discrepancies between morphological findings by X-ray or endoscopic examination and hemodynamic findings by SSP were existed. These results suggest that diagnosis of esophageal varices should be performed both from morphological and hemodynamic points of view. In measuring the spleen to liver time by SSP, the spleen to liver time was significantly prolonged in liver cirrhosis.
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  • Hisaaki KAJI
    1978 Volume 75 Issue 6 Pages 856-868
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Studies were made on relationships between splenoportographic findings and clinical features such as G.I. Bleeding, splenomegaly or hepatic encephalopathy in 82 cases with portal hypertension.
    An episode of G.I. Bleeding was often noted in cases, in which both the coronary gastric vein and short gastric vein were visualized by splenoportography. The episode of G.I. bleeding was seen in 46.4% of cases, in which the coronary gastric vein was more prominently visualized than the short gastric vein and in 72.7% of cases, in which the size of the coronary gastric vein was over 10mm in diameter.
    A close relationship was observed between degree of splenomegaly and one of tortuosity of the splenic vein, however, no relation was noted between degree of splenomegaly and the episode of G.I. Bleeding.
    In cases of hepatic encephalopathy, the intra- and extra hepatic portal veins were not visualized, however, splenorenal shunts were well observed and these shunts seem to be a cause of hepatic encephalopathy.
    In cases of extra hepatic portal obstruction, complicated shunts were numerously noted with characteristic features.
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  • Jinju IWABUCHI
    1978 Volume 75 Issue 6 Pages 869-881
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    It has been widely recognized that the disturbance of absorption in various intestinal disorders are caused by the quantitative and qualitative changes of bile acids contained in intestinal juice. Though several reports have been published regarding the composition of bile acids, the results were controversial particularly when lesions are localized either in terminal ileum or colon. Therefore, the analysis of bile acids composition in the duodenal juice taken by means of the stimulation of caerulein was performed with the newly-deviced technique of gas-liquid chromatography combined with thin-layer chromatography. The cases studied were diffuse ileal disease, blind-loop syndrome, terminal ileal disease, colonic disease and gastrectomy.
    The following results were obtained. (1) The glycine: taurine ratio was 4.1±1.1 in healthy subjects, whereas a marked elevation was noticed in diffuse ileal disease and blind-loop syndrome, the ratio being 25.5 and 17.2, respectively. In sharp contrast, there was no changes in the ratio in cases of terminal ileal and colonic diseases. (2) Cholic acid: chenodeoxycholic acid:deoxycholic acid: lithocholic acid was 0.8:1:0.4:0.03 in healthy subjects; 0.8:1:3.3:0.3 in cases of blind-loop syndrome. In cases of terminal ileal and colonic diseases, the ratio was 0.8:1:0.04:0.04 and 0.7:1:0.07:0.06, respectively. Namely, the proportion of deoxycholic acid noticeably declined.
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  • Isao AOKI
    1978 Volume 75 Issue 6 Pages 882-890
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The pancreatic response to exogenous secretin was studied in 24 anesthetized dogs provided with two pancreatic fistulas. The pancreatic secretions from the right and left lobes were collected separately and simultaneously, through polyethylene tubes inserted into the main duct at the orifice of the duodenum and at the pancreatic angle.
    Secretin-stimulated volume and electrolyte outputs, when calculated per wet weight of the tissue, were significantly greater in the left lobe than in the right lobe. There were no significant difference in electrolyte concentrations and amylase secretion.
    The reason of the dominant secretory response in the left lobe, at present, is not clear. It may be largely due to the difference of the absolute amount of secretin delivered to its target cells, resulting from the difference of blood flow rate.
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  • Tsuyohiko HONDA, Yoichi SAITOH, Seiki MATSUNO, Eishi MIYASHITA
    1978 Volume 75 Issue 6 Pages 891-901
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The inhibitory effects of eight amino acids on the exocrine and endocrine pancreatic function were studied in mongrel dogs with chronic gastric and pancreatic fistulae. Each amino acid was given intravenously under the basal stimulation with secretin and pancreozymin.
    Inhibition of the pancreatic exocrine function in volume of the pancreatic juice and amylase output were caused by Asparagine, Arginine, Isoleucine and Phenylalanine.
    Their highest decreasing ratio were 23% and 53%, 15% and 27%, 13% and 27%, 14% and 19% respectively. However, no significant changes were shown in bicarbonate concentration. There were no significant inhibition by Threonine, Glycine and Methionine in volume, amylase and becarbonate. On the other hand, Valine caused increase in volume and amylase output. The highest increasing ratio were 13% and 15% respectively.
    With those amino acids infusion which caused inhibition of the exocrine pancreatic function, the rise in the serum levels of IRG were demonstrated, but no significant change in the serum level of IRI was illustrated in each amino acid infusion.
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  • Yukinori OKAZAKI, Mitsuo AZUMA, Kiyohiro KAWAHARA, Makizo HIRATA, Ktsu ...
    1978 Volume 75 Issue 6 Pages 902-908
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hamamatsu medical center
    Yasuhiko SAMESHIMA, Masayuki UCHIMURA, Yoshihiro MUTO, Shinji WAKI, Hi ...
    1978 Volume 75 Issue 6 Pages 909-915
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • an unusual complication of cholelithiasis
    Koichi SHIBASAKI, Shinichi MORINAGA, Fumihiro ICHIDA
    1978 Volume 75 Issue 6 Pages 916-921
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Kohji KONISHI, Kazuo HIROSE, Hiroshi SAKUMA, Yoshio KINAMI, Shoichi KO ...
    1978 Volume 75 Issue 6 Pages 922-926
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Shinichiro ITO, Tadashi TACHIBANA, Shigeru MAEDA, Toshinori NAKATA, Ma ...
    1978 Volume 75 Issue 6 Pages 927-934
    Published: 1978
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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