Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 76 , Issue 12
Showing 1-14 articles out of 14 articles from the selected issue
  • Makoto YOSHIDA, Sachio OTSUKA
    1979 Volume 76 Issue 12 Pages 2365-2375
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    An acute UL-II ulcer was made on the mucous membrane of the stomach of the mongrel adult dogs by contact freezing of the serous membrane at a laparotomy under an anesthetic. We studied pathophysiological changes in the fibrinolysis, the coagulation and kinin system of blood while the gastric ulcer was being made experimentally and related those changes to the abnormality in the fine vascular formation at the ulcerous spot.
    The experimental ulceration advanced due to the disturbance in the circulation in the capillaries within the tela submucosa of the stomach. In the beginning of the ulceration, a great amount of the tissue plasminogen activator was isolated both in the ulcerous area and in distant areas of normal state. No more isolation was observed afterwards at the ulcerous spot, but the secondary isolation was observed in periphery and distant normal areas. As the ulceration advanced and when the tissue was impaired, kinin system in the tissue was isolated. Studies of morphological changes by microangiogram disclosed that there were an abnormal enlargement of the capillaries in tela submucosa and an enhancement of their permeability. At the same the coagulation factors V and VIII were obviously affected by ulceration. However, the laparotomy itself gave only transient effects to the platelets and fibrinogen. While the experimental ulceration was advancing, there was some correlation between changes in the fibrinolysis, the coagulation, and the kinin system in process of time and morphological changes occurred to the lesion areas.
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  • Hiroshi FURUKAWA, Takeshi IWANAGA, Toshio TERASAWA, Osamu ISHIKAWA, Ha ...
    1979 Volume 76 Issue 12 Pages 2376-2381
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In 1540 human gastric cancers which were surgically resected, the ratio of Borrmann 4 type to all types was higher in female (7.4%) than in male (3.1 %). Histlogically, the incidence of poorly differentiated adenocarcinoma among total gastric carcinoma was 26.3% in male and 47.8% in female.
    In experimental rats, adenocarcinoma in grandular stomach induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was observed more frequently in male rat than in female. When estradiol or estriol was injected combined with the administration of MNNG to male rats, the incidence of carcinoma was lower than the control group and histologically, some of them were poorly differentiated adenocarcinoma.
    From these findings, we suspect female sex hormones might inhibit or modify the action of promotors in carcinogenesis.
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  • I. Its relationship to the Atrophic Border of Atrophic Gastritis
    Nobuhiro SAKAKI, Yozo IIDA, Kiwamu OKITA, Yukinori OKAZAKI, Susumu KAW ...
    1979 Volume 76 Issue 12 Pages 2382-2388
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Localization of gastrin (G) cell in the intermediate zone was observed by indirect im-munofluorescence method. The samples of gastric mucosa, obtained by endoscopic biopsy or from resected stomach, were fixed with pre-cooled 95% ethanol, and stained with rabbit anti-gastrin serum (CIS) and FITC-labelled goat anti rabbit IgG serum.
    At first, we confirmed the existance of G cells in the intermediate zone. The G cell population was dominant in the mid-zone and rare in the lower-third of the glands in the intermediate zone. Futhermore, the G cells were seen at the fundic side of the atrophic border, in where fundic glands were replaced with pseudopyloric glands.
    These results presented herin strongly suggested that the G cells might newly appear at the intermediate zone with the spread of atrophic gastritis.
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  • II. Histological Grading of Atypicality with Special Reference to Malignant Change
    Hiroshi HABU, Kazuo HOSHI, Matsutoshi MENJO, Nozomu AOKI
    1979 Volume 76 Issue 12 Pages 2389-2399
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Histological examinations were made on the 27 "borderline atypical epithelial lesions" found at the 22 surgical specimens of the human stomach. The grade of their atypicality was classified into four groups (Groups II, III, IV and V) according to "the criteria for histological diagnosis of biopsied specimen of gastric mucosa" edited by Japanese Research Society for Gastric Cancer.
    Atypical epithelial lesion was composed of two or more different groups of atypicality in 15 out of 27 lesions (56%), in which each border of two different groups, such as Group II and III, or Group III and IV, was poorly demarcated with gradual transition. Focus of well differentiated adenocarcinoma was found in 5 lesions (19%).
    Since coexistence of cancer focus is not rare, radical resection of "borderline atypical epithelial lesion" should be advised in the following conditions, 1) elevated lesion over 2 cm in size, 2) polypoid lesion of pedunculated type, and 3) mucosal biopsy revealing atypism over Group II.
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  • Masaharu TSUCHIYA, Yoshio MUNAKATA, Norifumi HIBI, Hiroshi NAGATA, Tet ...
    1979 Volume 76 Issue 12 Pages 2400-2409
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Immunological mechanism has been considered to be one of the most important factors in the pathogenesis of ulcerative colitis. It is divided into cellular and humoral immuno-logical reactions. There have been few reports, that immediate hypersensitivity of humoral immunity might participate in the pathogenesis of ulcerative colitis. In ulcerative colitis we examined several factors of immediate hypersensitivity. (Circulating eosinophils, Serum IgE, Plasma histamine, Plasma CAMP & cGMP, Tissue eosinophils, Mast cells, and IgE containing cells).
    We observed increased plasma histamine levels, tissue eosinophilia, decreased number of mast cells, and increased number of IgE containing cells. These findings were considered to have a correlation with each other and with the histological grade. So we consider the immediate hypersensitivity is a very important pathogenetic factor in ulcerative colitis. About an effect of adrenocortical steroid on ulcerative colitis, we observed it might be an inhibitor of the immediate hypersensitivity, and confirmed its clinical and histological efficacy.
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  • Kohdoh ISHII, Hisao SHIBATA, Nobuo YAMADA, Hideaki NAKAZAWA, Haruya OK ...
    1979 Volume 76 Issue 12 Pages 2410-2414
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Plasma levels of catecholamine(CA) and c-AMP were studied in patients with liver disease in an attempt to evaluate the role of autonomic nervous as well as vascular system in liver disease. The patients consisted of the following: 22 cases of liver cirrhosis, 15 cases of chronic hepatitis, and 20 cases of acute hepatitis. CA was carried out by automatic rapid liquid chromatography and c-AMP was determined using CPBA method. Normal plasma values of epinephrine(EP), norepinephrine (NE) and c-AMP were as follows; below 0.12ng/ml, 0.04-0.35ng/ml and 8.3-13.5p molelml, respectively. CA values revealed that no elevation of EP was found in all patients examined; whereas a rise in NE was solely seen in patients with liver cirrhosis, showing in 17 out of 22 (77.3%) elevated and the value was 0.55±0.37ng/ml (mean±S.D.) (p<0.01). On the other hand, c-AMP indicated comparatively high in the patients with acute hepatitis (20.3±8.3) and in those with liver cirrhosis (24.2±8.9), contrasting with the lowered levels in those with chronic hepatitis (13.9±3.3) (p<0.01). In comparing these data with other laboratory findings in the patients with liver cirrhosis, NE had a correlation with the serum levels levels of gammaglo-bulin (r=0.6514, t=3.84>2.90). Furthermore, hepatic angiography showed marked cork screw appearance in the cases with elevated NE values.
    The data obtained lend strong support to the view that derangement of sympathetic nervous system with resultant disorder of vasoactive substances are involved in chronic liver disease, and c-AMP may be responsible for the repair of wound tissue.
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  • Part II. Changes of Lipid Composition of Erythrocyte Membrane in Obstructive Jaundice
    Shinichiro YAMAMOTO, Yoshinobu TAKEMOTO, Sachiko YAMASHITA, Katsuhiko ...
    1979 Volume 76 Issue 12 Pages 2415-2431
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Lipid composition of red cell membrane and its correlation with osmotic resistance were examined in obstructive jaundice. By using Iatroscan TH-10 TLC analyzer, lipids of red cell membrane were separated into free cholesterol (FC), phosphatidyl ethanolamine (PE), phosphatidyl serine (PS), phosphatidyl choline (PC) and sphyngomyelin (SM). FC: PE: PS: PC: SM ratio were 31.0: 20.1: 12.6: 19.5: 16.8 in normal controls. In benign biliary obstruction there were little changes compared with normal controls, while in malignant biliary obstruction FC: PE: PS: PC: SM were 39.1: 11.4: 8.4: 30.0: 11.0, which indicated increase of FC and PC and decrease of PE and SM. In addition, total lipids, FC/PL ratio and PC+SM/PE+PS ratio were significantly greater in malignant biliary obstruction.
    Hemolysis end point (HEP) correlated well with PE and SM (p<0.001) and a good correlation was also noted with FC, PC and total lipids (p<0.01). Lipid composition of erythrocyte membrane sharply reflects the changes of osmotic resistance of erythrocyte and seems to be useful in the diagnosis of obstructive jaundice.
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  • Akira NAKAYASU, Nobutaka KUBOTA, I.G.M Cleator
    1979 Volume 76 Issue 12 Pages 2432-2441
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    1) Serum glucose, immunoreactive insulin (IRI), and immunoreactive gastric inhibitory polypeptide (GIP) were measured after a 33-gm. intravenous (i.v.) glucose injection, a 100-gm, oral glucose ingestion and a 66-gm. ingestion of corn oil in 10 normal subjects and 10 mild maturity-onset diabetics (non-obesity). The IRI response to oral glucose ingestion in diabetics was significantly increased at 120 and 150 min. (p<0.05) compared with those of the normal subjects. Fasting serum IRGIP levels were not significantly different between diabetics and normal subjects. After glucose or triglyceride ingestion, interval and integrated IRGIP responses were not significantly different in the two groups.
    2) Five units of regular insulin was infused with saline for 30 min. before and 30 min. after 100-gm, of oral glucose load. After oral glucose and continued i.v. insulin, IRGIP level was significantly lower than that following glucose alone at 45 min. (p<0.05).
    These results demonstrate that 1) IRGIP levels are not augmented in our studies on patients with mild diabetes and insulin hypersecretion and 2) exogenous insulin inhibits GIP release. It is suggested that endogenous insulin may suppress endogenous GIP by a negative feedback mechanism in man.
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  • Report of 2 Cases with a Special Reference to Sarcoid Reaction in Malignant Neoplasms
    Tomikazu YAMAMOTO, Reinaldo Takejima, Hiroyuki TATEISHI, Yukitaka NISH ...
    1979 Volume 76 Issue 12 Pages 2442-2446
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hidemitsu HIRABAYASHI, Kenjiro KAWAHARA, Kendo KIYOSAWA, Atsuo NAGATA, ...
    1979 Volume 76 Issue 12 Pages 2447-2451
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • AMYLASE BINDING SUBSTANCE AND PANCREATIC FUNCTION
    Rokuro MATSUMOTO, Terukatsu ARIMA, Kozo KAWAI, Kinichiro SUWAKI, Takeh ...
    1979 Volume 76 Issue 12 Pages 2452-2455
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yoshinori TANAKA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1979 Volume 76 Issue 12 Pages 2456
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tetsuo ARAKAWA, [in Japanese], [in Japanese]
    1979 Volume 76 Issue 12 Pages 2457
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuro YAMAMOTO, [in Japanese], [in Japanese]
    1979 Volume 76 Issue 12 Pages 2458
    Published: December 05, 1979
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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