Simultaneous measurement of membrane potential (PD) and intracellular K
+ concentration (C
K) was performed on rat liver slices with double barreled potassium ion-selective microelectrodes, and the data were used for the judgement of cellular injury of antineoplastic agents. Further, an action of coenzyme Q
10 minimizing the cellular injury was examined.
Both the membrane PD and intracellular K
+ concentration were significantly decreased by administration of antineoplastic agents (Mitomycin C "MMC" or 5-Fluorouracil Dry Syrup "5-FUDS").
It is suggested, therefore, that both MMC and 5-FUDS would bring about a hypofunction of hepatic cells as a result of their side effects, being characterized by a decrease of cellular energy metabolilm, such as inabilities of cellular K
+ accumulation and Na
+ extrusion out of the cell. Administration of coenzyme Q
10 was recognized to partially restore these abilities.
Thus, it is considered that a certain side effects of antineoplastic agents on rat liver cells can be prevented, at least in part, by a combination therapy with the administration of coenzyme Q
10.
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