Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 77 , Issue 11
Showing 1-16 articles out of 16 articles from the selected issue
  • Endoscopical and Histopathological Analysis
    Makoto Ishikawa, Mitsuo Narusue, Nobuyuki OHONISI, Akira GOHCHI
    1980 Volume 77 Issue 11 Pages 1705-1710
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Fourteen minute gastric carcinoid lesions were demonstrated in 3 resected stomach. Endoscopical and histopathological studies on the developement of carcinoid tumor were carried out about these lesions. We could recognize endoscopically only 6 lesions in diameter of more than 2mm which already invaded to submucosa. Our findings disclosed that the carcinoid lesions developed from deep portion of gastric mucosa and easily invaded to submucosa. At first, the mucosa is apparently lifted slightly and the lesion indicated to hemispherical appearance. The lesion in 5mm diameter has the bridging fold as a submucosal tumor. The lesions in growth accompanied ulceration and metastased to regional lymph node.
    These findings revealed that the radical gastrectomy as gastric cancer are necessary, when carcinoid lesions are demonstrated.
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  • Effect of Water-immersion Stress
    Tetsuo ARAKAWA, Hajime NAKAMURA, Kenzo KOBAYASHI
    1980 Volume 77 Issue 11 Pages 1711-1716
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Recently, prostaglandin (PG) cytoprotection has been of great interest in the gastrointestinal tract, but there are few reports about endogenous PGs in gastric mucosa. We established a method of determining intramucosal PGE2 in the previous study. We estimated here the levels of B-, E1-, E2-, F-type of PG and we have investigated the effect of stress on PGE2 and cyclic AMP levels in rat gastric mucosa.
    The level of intramucosal PGE2 was markedly high compared with other types of PG both in fundus and in pyloric antrum in the untreated group. In the stress series, the PGE2 levels was increased in the early phase in which any mucosal lesion was not observed. Then it was decreased in the late phase accompanied with production of the gastric mucosal lesion. The cyclic AMP level was also increased in the early stress phase while it was not influenced with stress when pretreated with indomethacin.
    These results suggest that the lack of intramucosal PGE2 may cause production of the stress ulcer.
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  • Hiroshi IMAMURA, Mitsuo ISHIZAWA
    1980 Volume 77 Issue 11 Pages 1717-1724
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effects of prostaglandin E1 (PGE1) on mucin secretion and mucosal lesions in rat stomach induced by indomethacin and cold restraint were investigated.
    The mucus content was measured by the alcian blue binding method. Intravenous infusion of PGE1 (10μg/kg) for 1 hour increased the total amount of mucosal and adhesive mucus at the rate of 14.2%. The rate of increase in the amount of adhesive mucus on the surface epithelium was 16.7%. Both treatment by oral administration of indomethacin (60mg/kg) and by cold restraint at 4 °C for 1 hour produced acute mucosal lesions and decreased the mucus contents in gastric mucosa at the rate of 17.8% and 16.1%, respectively. However, the mucosal lesions and decreases in mucus content were markedly inhibited by the administration of PGE1 (10μg/kg) for 1 hour infused simultaneously with the above treatments.
    These results suggest that a concentration of PGE1 so low that it hardly inhibited gastric acid secretion could induce an increase in mucin secretion and prevent ulcer formation in rat stomach.
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  • Special Reference to the Stage of Gastric and Duodenal Ulcer
    Keiko SHIRATORI
    1980 Volume 77 Issue 11 Pages 1725-1732
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Responses of serum gastrin and gastric acid output to a constant intravenous infusion of secretin were studied in 37 cases of peptic ulcer and a case of Zollinger-Ellison syndrome (ZES). The responses were closely related to the activity of the ulcer. Serum gastrin increased in the active stage and decreased in the scar stage, in response to the stimulation. Although either Boots secretin or Eisai secretin and or GIH secretin was infused in some cases, these different responses were observed in the same individual. Gastric acid output was significantly suppressed by secretin infusion only in the scar stage. There was no difference in the attitude between gastric and duodenal ulcers. Our results may indicate that a paradoxical response of serum gastrin to the secretin infusion is not necessarily specific to ZES. In a case of ZES, serum gastrin response to secretin infusion markedly increased in the active stage, but slightly increased in the scar stage.
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  • Setsuo HOSHIJIMA
    1980 Volume 77 Issue 11 Pages 1733-1740
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Cell proliferation kinetics of human gastric mucosa were studied in healthy subjects, atrophic gastritis and gastric ulcer. Biopsy specimens, obtained by a fiber gastroscope were incubated with 3H-thymidine and autoradiographs were prepared.
    The highest labelling indices in the mucosa were found in the intermediate zone, and the highest value was obtained in atrophic gastritis. In gastric ulcer, the marginal mucosa was highly labelled in active and healing stage, and the highest value was obtained in scarring stage. Afterwards the value showed a gradual decrease and reached normal limit over three months.
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  • Ryuichi KANAYAMA, Akira TAKADA, Jinichi NEI
    1980 Volume 77 Issue 11 Pages 1741-1745
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have previously reported that high fat diet increased alcohol metabolic rate through the microsome. In this experiment the effects of fatty liver per se and fatty acid composition of dietary fat upon alcohol metabolism were studied to clarify the mechanism of increased alcohol metabolism by high fat diet. Alcohol metabolic rate were not increased in fatty liver induced by choline-deficiency and orotic acid compared to control. No clear difference, except corn oil-alcohol group, existed among experimental groups fed with coconut oil, cotton seed oil and corn oil as dietary fat. In corn oil-alcohol group, alcohol metabolic rare was increased slightly.
    These results suggest that fatty liver per se or qualitative difference of dietary fat is net responsible for increased alcohol metabolic rate by high fat diet and quantitative difference of dietary fat is important in alcohol metabolism.
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  • Yoshio TAKASAKURA
    1980 Volume 77 Issue 11 Pages 1746-1755
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Plasma or serum from patients with several liver diseases was found to inhibit lymphocyte blastogenesis stimulated by lectins. Most of these reports were designed to evaluate the responsiveness to lectins of homologous lymphocytes from normal subjects cultured in the plasma or serum suspected of containing inhibitory factors. The degree of variation in the preparation of standard plasma or serum, and choice of lectin as well as the amount needed to support lymphocyte blastogenesis was not specified yet. The author showed that lymphocytes from normal subjects, when stimulated at the two different concentration of concanavalin A (Con A), give the same response when cultured in their own serum compared with when cultured in heat inactivated AB type serum. This indicated a better rate assay method for the evaluation of serum factor to support lymphocyte blastogenesis.
    Using this method the serum lymphocyte blastogenesis index (SLBI) were determined in 64 cases (96 samples) with liver diseases. In the acute phase of acute hepatitis SLBI were revealed higher than the normal range. However, in the recovery phase SLBI were demonstrated within normal range or lower than the normal range. SLBI of patients with chronic active hepatitis and liver cirrhosis, who showed unstable serum GOT levels, were higher than that of patients who showed stable serum GOT levels. Although there is no correlation between appearance and disappearance of HBs antigen in serum, there is a significant correlation between SLBI and serum GOT levels.
    The serum lymphocyte blastogenesis factors may help to promote the chronicity of liver diseases.
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  • The Clinicopathological Study of 10 Cases
    Yoshitane KOSAKA, Shozo AKETA, Yukihiko TAMEDA, Kojiro TAKASE, Masayos ...
    1980 Volume 77 Issue 11 Pages 1756-1765
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Ten patients with constitutional indocyanine green (ICG) excretory defect were reported. The clinical pictures, blood chemistries, ICG plasma disappearance rate, transfer rate of ICG from plasma to liver, binding of ICG to plasma proteins and histology of the liver were studied. The subjects ranged in age from 22 to 58 years (seven men and three women).
    The ICG plasma disappearance rate (KICG) and the retention rate at 15 minutes (R15, ICC) were markedly abnormal and averaged 0.0190±0.0048 and 7.70±5.99% respectively. The transfer rate of ICG from plasma to liver was markedly decreased with a mean value of 0.0222±0.0054.
    Histological findings of the liver revealed that, on light microscopic examination, three had fatty liver and one had chronic active hepatitis, while the remaining six subjects were normal. Electron microscopic findings revealed increase of lipofuscin granules, altered morphology of mitochondria and increase of reticulum fibers.
    These findings suggest that there is some relationship between morphological changes of the liver and the hepatic excretory mechanism of ICG.
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  • Akihiro FUNAKOSHI, Takashi YAMAUCHI, Hiroshi IBAYASHI
    1980 Volume 77 Issue 11 Pages 1766-1769
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A high incidence of experimental pancreatic cancers was induced in Syrian golden hamsters following weekly subcutaneous injections of 500 mg/kg DIPN in order to study the enzymatic diagnosis of pancreatic cancer. In morphologic aspects the induced pancreatic cancers closely resembled ductal cell adenocarcinomas of humans.
    After DI PN treatment the hamsters were sacrified at 12, 16, 20, 22, 25 weeks, and RNase activities (Poly U, Poly C, Poly G, Poly A) in serum and pancreatic extract were assayed respectively. Hamsters with pancreatic cancer at 25 weeks exhibited elevated uridine base specific RNase levels. These results suggest that the changes of RNase may be a good indicator in the diagnosis of pancreatic cancer.
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  • Teruo NAKAMURA, Kenichi IMAMURA, Yasuhisa ABE, Tadashi MIYAZAWA, Kazuo ...
    1980 Volume 77 Issue 11 Pages 1770-1776
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The conjugated bile acid composition was investigated in duodenal juice of eleven patients with chronic pancreatitis, and the bile acid composition and hydroxy fatty acid concentration was also analized in feces of nine patients with chronic pancreatitis in a gas chromatograph.
    The results showed a markedly reduced proportion of glyco-CDCA in the duodenal juice of the patients wish chronic pancreatitis as compared with the healthy controls. Among the pancreatic exocrine functions by pancreozymine-secretin test, there was a significant correlation between maximal bicarbonate concentration and the proportion of glyco-CDCA. The mean of glycine-to taurine-conjugated bile acid ratio (G/T ratio) in duodenal juice was 2.91±0.4 in the patients and 1.91±0.7 in the controls.
    The amount of fecal bile acids excretion was significantly greater in the patients than in the control subjects. This abnormality was mainly due to significant increase in fecal excretion of CDCA in the patients when compared with the controls.
    The amount of fecal excretion of total fatty acids was also observed to be significantly increased in the patients, but there was no significant difference in the proportion of hydroxy-fatty acid in both groups. These studies suggest that there is a mild bile acid malabsorption in patients with chronic pancreatitis. However, no obvious evidences which suggest bacterial overgrowth in the intestine were derived from the measurement of fecal hydroxy-fatty acid.
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  • Kozo TAMAI
    1980 Volume 77 Issue 11 Pages 1777-1787
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to clarify the mode of development of pancreatic ductal lesions in chronic pancreatitis., the changes of the ERP findings were investigated in 30 cases with chronic pancreatitis, 29 cases with suspected chronic pancreatitis, and 16 cases with non-pancreatic disease, in whom ERP was performed more than twice in the period of 1 year or longer.
    Notable changes of the ductal system in the time course were obsei ved in the most cases with chronic alcoholic pancreatitis and suspected chronic alcoholic pancreatitis. Dilatation and partial stricture of the main pancreatic duct were neither permanent nor terminal findings as presumed generally, but the alternate transition from stricture to dilatation or vise verse was observed in the ERP serially followed up for more than 1 year. And moreover, in cases with advanced lesions in the initial ERP findings, the progressive changes were seen even after the abstinence of drinking or surgical intervention. In the other groups the ductal changes during the follow-up period were limited in grade or in incidence except for one case with pancreatic calculi.
    These result indicate that the evolution of ductal lesions in chronic alcoholic pan creatitis is obviously different from those in chronic non-alcoholic pancreatitis.
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  • Yukio TAKAYASU, Norio NAKAO, Tomoko KUSANO, Yohei WADA, Kohi MIURA, Ta ...
    1980 Volume 77 Issue 11 Pages 1788-1793
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Conventional computed axial tomography has been used to assess the pancreatic disease, but its diagnostic utility is not evaluated so high. This paper describes a clinical use of reconsti ucted coronal and sagittal images of pancreas. Reconstruction CT images were obtained by Siemens body scanner, Somatom SD and image viewer Evaluskop.
    Scan time was 4.5 seconds and the scans were obtained at intervals of each 3mm, with a slice thickness of 4mm. Multiplanar reconstruction has proven very useful in diagnosis of pancreatic disease and also in estimation of pancreatic volume. It can be expected to take an important place in pancreatic diagnostic study.
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  • VI: Clinical Evaluation of Percutaneous Puncture of Pancreatic Cysts
    Takeo YAMANAKA, Wakahiro NOGAMI, Yukio YOSHIDA, Kenichi IDO, Hideichi ...
    1980 Volume 77 Issue 11 Pages 1794-1804
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Ultrasonically guided percutaneous puncture of pancreatic cyst was performed on 5 patients with ultrasonically scanned cystic mass lesions in the left upper quadrant. The clinical purpose of the procedure is for (1) biochemical, bacteriological and cytological examinations of aspirated fluid of the cysts, (2) roentgenographic visualization of the cysts by direct injection of contrast medium, and (3) complete aspiration of the fluid of cysts for therapeutic treatment.
    The final diagnoses of these patients were pancreatic pseudocyst in 2 patients, pancreatic cystadenocarcinoma in 2 patients and cyst-forming metastatic lymphnode from gastric cancer in one patient, confirmed by exploratory laparotomy and/or autopsy.
    (1) Examinations of aspirated fluid of the cysts.-The aspirated fluid was proved fairly diagnostic. In pseudocyst, the aspirated fluid revealed very high concentration of amylase, malignant cells being not recognized cytologically. In cystadenocarcinoma, the aspirated fluid revealed low concentration of amylase and high concentrations of LDH and CEA, malignant cells being definitely recognized. In metastatic lymphnode cyst, on the otherhand, CEA was high and malignant cells were recognized, but both amylase and LDH were low in concentration. This method is of great value for differential diagnosis of cystic diseases of the pancreas. (2) Roentgenographic visualization of the cysts.-This method may be considered as very useful for clear demonstration of outline and position of the cysts. (3) Therapeutic external drainage of the fluid of cysts.-This technique was performed on 2 patients with pancreatic pseudocysts, but fluid retention recurred within a few days. The therapeutic value of the procedure is, however, still too early for the final evaluation.
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  • Kazuaki FUJISAWA, Hiromi UENO
    1980 Volume 77 Issue 11 Pages 1805-1809
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Joji HARATAKE, Goroku OHTA, Akio FUJIMURA, Toshio UENO
    1980 Volume 77 Issue 11 Pages 1810-1813
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hideo IKEHARA, [in Japanese], [in Japanese], [in Japanese]
    1980 Volume 77 Issue 11 Pages 1814
    Published: November 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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