Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 77 , Issue 12
Showing 1-17 articles out of 17 articles from the selected issue
  • Katsutoshi TANIGUCHI
    1980 Volume 77 Issue 12 Pages 1871-1878
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Gastric emptying time was evaluated in 228 peptic ulcer patients and 22 healthy volunteers as control using Gastroscintigram (GSG).
    The gastric emptying rate was expressed as half gastric emptying time (T 1/2). The gastric emptying patterns were classified into two groups; these were a linear and exponential pattern. The emptying rate in gastric ulcer patients was slower than in control, while that in duodenal ulcer patients was faster than control. These results suggest that there is relation between the emptying rate and the etiology of peptic ulcer. Among all the operations employed, the gastric emptying in sphincter preserving gastrectomy (SPG) for gastric ulcer and selective proximal vagotomy (SPV) for duodenal ulcer neared to that of control. This seemed to be most physiological.
    GSG was a accurate and useful method in selection of operation methods, estimation of dumping syndrome and evaluation of function of the operated stomach.
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  • Toshio NISHIOKA, Toshikazu SEKIGUCHI, Tsuneo OHWADA
    1980 Volume 77 Issue 12 Pages 1879-1889
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to study the effect of secretin on gastric and duodenal motor activity, continuous manometric recordings from stomach, duodenum and upper part of jejunum were performed by infused open-tipped method with a low compliance infusion pump on 20 healthy subjects.
    The contractile patterns of spontaneous migrating motor complexes in human subjects could be divided into two types of migrating motor complexes (MMCs): the one began from gastric phase with maximal gastric motor activity (gastrointestinal-MMC) and the other from duodenal phase (intestinal-MMC). The spontaneous intestinal-MMCs were never preceded by the maximal gastric motor activity.
    Secretin (Secrepan, Eisai Co., Ltd. Japan) was injected into the vein at 0.1U/kg, 0.25U/kg, 0.5U/kg, 1.0/kg and 2.0U/kg respectively. Over the dose of 0.25U/kg, secretin initiated contractions resembling the intestinal-MMCs. The intravenous administration of 2.0U/kg secretin developed secretin-induced MMCs in 11 of 13 subjects. Secretin-induced MMCs did not differ from spontaneous intestinal-MMCs in their contraction rate, conduction velocity, amplitude and duration. By comparison with gastrointestinal-MMCs, however, only the duration of secretin-induced MMCs and intestinalMMCs was significantly shorter.
    Secretin-induced MMCs developed by various doses of secretin did not differ each other in their characteristics of duodenal phase.
    From these results, we suggest that secretin may be involved in the initiation of spontaneous MMCs.
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  • Toshiki OGAWA
    1980 Volume 77 Issue 12 Pages 1890-1899
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Motilin release in response to various factors and its mechanism were studied in normal subjects and patients with peptic ulcer by various tests and in vitro experiments using a perifusion system. The ingestion of a meat soup, protein and fat elevated plasma motilin levels as well as duodenal acidification, but oral glucose and insulin-induced hypoglycemia significantly lowered them. The untreated patients with peptic ulcer revealed a similar pattern of motilin release to that of normal subjects after the meat soup ingestion, insulininduced hypoglycemia and duodenal acidification. The postvagotomy patients showed a decrease in plasma motilin during the insulin-induced hypoglycemia.
    The perifusion experiments demonstrated that motilin release from human duodenal mucosa into the perfusate was markedly stimulated by pH 2 solution and 15mM taurocholate, but not affected by the perifusion of glucose, fatty acid, amino acid, insulin and glucagon. Somatostatin inhibited motilin release from human duodenal mucosa.
    These results indicate that motilin release induced by meal ingestion depend upon the balance of food components and that in normal subjects duodenal acidification, bile acid and an unknown factor contained in the meat soup may participate, at least in part, in postprandial motilin release.
    The inhibitory effect of oral glucose load and insulin-induced hypoglycemia on motilin release may be attributable to a certain mediator mechanism which remains to be studied.
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  • Tsunesuke TOMODA, Yasuo NAKANO, Takashi KAGEYAMA
    1980 Volume 77 Issue 12 Pages 1900-1904
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In the preceding paper, the authors reported that the pattern of the intestinal flora usually changes during continuous intake of immunosuppressive or anticancer drugs. In this study, the possible effect of the continuous intake of lactobacilli on the pattern of the microflora was examined during the administration of these drugs in mice of a uniform genetic strain (C3H/He).
    Intestinal bacteria were isolated from the feces and identified by the method described in the previous report.
    It was noted that the concomitant intake of these drugs with lactobacilli caused increased numbers of lactobacilli and decreased numbers of Escherichia coli. Other strains of lactobacillus than those given were also increased in the digestive canal in the mice. Lactobacilli were found in large numbers in the stomach, and small and large intestines.
    After the administration of lactobacilli was discontinued, they remained in the digestive canal if administration had continued for 20 weeks.
    These findings suggest that proliferation of lactobacilli instead of Escherichia coli may be beneficial in preventing the side effects of immunosuppressive or anticancer drugs.
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  • Yuji YAMASHIRO
    1980 Volume 77 Issue 12 Pages 1905-1914
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The author investigated the binding activities of rat and human liver cytoplasmic proteins with organic dyes, sulfobromophthalein (BSP) and indocyanine green (ICG), using the gel filtration method. Each of X, Y and Z protein of rat liver revealed the characteristic natures of selection and regularity when binding with BSP. These characteristics of proteins were not observed in binding with ICG.
    Two kinds of rat liver protein bound with BSP were separated by using the stepwise elution method. One had high affinity and low capacity, and the other had low affinity and high capacity. There were no apparent changes in affinity and capacity of the two proteins when bound with ICG. A definite difference was observed with the elution pattern of proteins and the binding of these two dyes between human and rat liver cytoplasmic proteins. There was no difference in the binding with dyes of liver proteins in cases with Rotor's syndrome, Crigler-Najjar syndrome or constitutional ICG excretory defect.Yasuhiro MIZOGUCHI, Yoshihide SAKAGAMI, Takashi SHIBA.
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  • Yasuhiro MIZOGUCHI, Yoshihide SAKAGAMI, [in Japanese], Toshihiro HIGAS ...
    1980 Volume 77 Issue 12 Pages 1915-1922
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The cholestatic factors were produced from the sensitized lymphocytes by specific antigenic stimulation in vitro. These active principles were fractionated by a gel filtration using Sephadex G-75 column followed by DEAE-cellulose column chromatography. Two active fractions obtained by a latter chromatography exhibited a marked intrahepatic cholestasis when they were infused into the mesenteric vein of rats. Although the cholestatic activity of these two fractions did not influence by RNase or DNase digestion, their activities were completely inactivated by treatment of either trypsin or neuraminidase.
    These results suggest that the cholestatic factors may have a glycoprotein nature.
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  • Mikio ZENIYA, Yumiko KATO, Hiroshi TAKAHASHI, Masamichi DEURA, Yoshika ...
    1980 Volume 77 Issue 12 Pages 1923-1929
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The K-cell in peripheral blood in patients with acute and chronic liver diseases was studied by our own plaque method using sheep-red-blood-cell as a target cell. With the appliance of this method, the K-cell population was assayed easily and proved to be very useful for clinical work. In chronic liver diseases, the K-cell population was significantly decreased compared with that in normal subjects. The blocking of Fc-receptor by serum from the patients was shown to be one of the causes for this decrease. Adreno-corticosteroid decreased the K-cell population in vitro and in vivo. A sequeantical assay of K-cell revealed the change of the K-cell population according to the course of the disease.
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  • Masatoshi NAKAGEN, Norio SAWABU, Hideo SENDAI, Tokio WAKABAYASHI, Kenj ...
    1980 Volume 77 Issue 12 Pages 1930-1937
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The so-called variant ALP, one of the ALP isoenzyme, was detected in 17 of 94 (18.1%) patients with hepatocellular cancer using the polyacrylamide gradient gel electrophoresis. This isoenzyme seemed to have high specificity for hepatocellular cancer because it was not found in patients with benign hepatobiliary diseases and cancers except hepatocellular cancer.
    Prevalence of variant ALP was lower than those of AFP (400ng/ml<) and novel γ-GTP which had been reported to be specific for hepatocellular cancer in our previous publication. The other hand, the appearance of variant ALP had no relation to serum titer of AFP and the positivity of novel γ-GTP and, in 4 of 94 patients with hepatocellular cancer, this isoenzyme was only detected among these three markers.
    Now, we have no valuable tumor marker for diagnosis of hepatocellular cancer in which serum levels of AFP is low and novel γ-GTP is negative.
    Therefore, examination of variant ALP combined with AFP and novel γ-GTP is expected as one of useful biochemical approaches.
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  • Shujiro TAKASE
    1980 Volume 77 Issue 12 Pages 1938-1947
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Diagnostic significance of the changes in serum prealbumin, serum α2-heat stable (HS) glycoprotein and hepaplastin test, which are rapid turnover serum proteins mainly synthesized in the liver, in predicting the development of severe form of acute hepatitis was investigated. α--HS glycoprotein showed significantly low levels in the cases with massive or submassive hepatic cell necrosis. And changes in hepaplastin test value correlated with the extent of hepatic cell necrosis. Consequently, development of massive or submassive hepatic cell necrosis was highly predictable from prominent decreases in both of α2-HS glycoprotein and hepaplastin test value and zonal necrosis could be predictive from moderate decrease of both proteins in the early phase of the diseases. Since prealbumin levels were abnormally low in almost cases of acute hepatitis, differentiation of severe form of hepatitis was impossible by prealbumin level.
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  • Akira FUJISHIMA, Hideo FUJITA, Michiko SAITO, Yuichi SHIRAI, Mitsuo SU ...
    1980 Volume 77 Issue 12 Pages 1948-1954
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Effect of the glucagon-insulin (G-I) treatment upon hepatic encephalopathy was studied in 4 cases with fulminant hepatitis and 7 cases with cirrhosis of the liver. Of these 11 cases, 6 cases survived, and the awakening from consciousness disturbance was obtained in 9 cases. The mean treatment period before obtaining the awakening was 3.7 days, and this was accompanied by decreased blood ammonia levels, the mean pre-treatment value being 158 μg/dl, whereas the mean value after awakening from coma being 70μg/dl. Of liver function tests studied, there were marked improvements of serum GOT and GPT values, whereas serum albumin levels showed a tendency to fall by this treatment. Blood total amino acid contents were found to decrease by this treatment in normal controls, in patients with cirrhosis of the liver without encephalopathy, and also in patients presenting hepatic encephalopathy. These results are in support of the usefulness of the G-I treatment, no less better than conventional methods of treatment of hepatic encephalopathy, and the possible mechanism of action was discussed.
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  • Takashi MATSUSHIRO, Hiromi CHO, Hideyuki NAGASHIMA, Susumu OMOKAWA, Ky ...
    1980 Volume 77 Issue 12 Pages 1955-1962
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Bile samples were obtained from 15 patients with gastric cancer or other lesions without biliary tract disease as a control and from 13 patients having cholesterol gallstones at laparotomy. One mixed stone was cut in half and thin serial sections, 10 microns in thickness, were prepared from the cut surface after Nakamura's method. The solubility of cholesterol in these gallstone sections after emersion in the bile samples was observed microscopically withdrawing the sections 1 hour, 3 hours, 5 hours and 24 hours. Among 15 control bile samples, a dissolution was observed in 9 gallstone sections after 1 hour, and in 6 sections after 3 and 5 hours. Bile samples of cholesterol stone cases had dissolved 3 sections after 1 hour, 7 sections after 3 and 5 hours. Dissolution did not occur in the remaining 3 sections. In bile composition, cholesterol (Ch) and total bile acid concentrations (TBA) in the controls were significantly higher than in bile of the cholesterol gallstone cases (P<0.05, P<0.02). Correlation between the bile composition and the solubility of cholesterol showed that bile samples having high TBA concentrations exhibited a greater dissolution ability even when the molar ratio of TBA to Ch were the same in both control and cholesterol gallstone bile. These findings lead us to conclude that the solubility of cholesterol in bile can not be expressed merely in terms of relative concentrations of Ch, phospholipid and TBA as the absolute concentrations of TBA also greatly influences the dissolution ability.
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  • Toshio SHIMAYAMA, Taketo KATSUKI, Fujiko NOZAKI, Takasuke YOSHIDA, Hir ...
    1980 Volume 77 Issue 12 Pages 1963-1967
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yuji HORIGUCHI, Madoka ITO, Sumio NAKASHIMA, Hiroshi NAKANO, Fumio MIZ ...
    1980 Volume 77 Issue 12 Pages 1968-1972
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masaru SHIMIZU, Junichi SUGIHARA, Masami OHYAMA, Yasuhiko KAWADE, Yasu ...
    1980 Volume 77 Issue 12 Pages 1973-1978
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hideo OZAKI, Seiji NAITO
    1980 Volume 77 Issue 12 Pages 1979-1983
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    One thousand two hundred and ten cases of pancreatic cancer collected from 63 major clinics in Japan were reviewed. Eight hundred and ninety three out of the 1210 cases were verified histologically. Resection was carried out in 38% of carcinomas of the head, 21% of the body and tail and 7% of the entire pancreas, and in 31% (274 cases) of total 893 cases.
    Carcinomas larger than 3.1cm were 85%, of which resectability was 25%, while carcinomas smaller than 3.0cm were 15%, of which resectability was 88%. In these small carcinomas, jaundice was recognized in 76% and symptoms in cases without jaundice were upper abdominal pain, nausea and vomiting, anorexia, palpable mass, general fatigue, back pain and emaciation. Percutaneous transhepatic cholangiography, endoscopic retrograde cholangiopancreatography and selective angiography were valuable to diagnose these small carcinoma.
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  • Sachiko YAMASHITA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1980 Volume 77 Issue 12 Pages 1984
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yukihiro TSUCHIYA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1980 Volume 77 Issue 12 Pages 1985
    Published: December 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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